My TSH is low and my T4 in the upper range but my T3 is barely in the lower end of the range and my GP says I am adequately replaced however I feel awful. I was diagnosed 13 years ago and have been up and down over the years but worse since having children now aged 5 and 3. My Dr refuses a trial of T3 and referred me to an endo but having seen the referral letter she has made it sound that my treatment is optimised and the consultant has cancelled my appt. I was wondering if I should self medicate and have purchased Cynomel. I am taking125mg levo and wondered how much Cynomel I should take, I was thinking of reducing T4 to 100mg and taking 5mg of T3 twice daily, does this sound right? My T3 was higher a couple of years ago and I was able to loose weight, I am now gaining weight with 1250 calories per day and exercise 5 days a week. Help please !!!!