Log in
Thyroid UK
91,803 members106,069 posts

Relationship between gestational transient thyrotoxicosis and vitamin D

Another vitamin D and pregnancy paper. Posted separately so that it doesn't get missed by anyone interested.

The other paper I posted about here:


Turk J Med Sci. 2016 Nov 17;46(5):1374-1378. doi: 10.3906/sag-1507-33.

Relationship between gestational transient thyrotoxicosis and vitamin D.

Küçükler FK1, Şimşek Y2, Görkem Ü3, Ayçiçek Doğan B4, Güler S1.

Author information

1Department of Endocrinology, Faculty of Medicine, Hitit University, Çorum, Turkey.

2Department of Endocrinology, Kayseri Training and Research Hospital, Kayseri, Turkey.

3Department of Gynecology and Obstetrics, Faculty of Medicine, Hitit University, Çorum, Turkey.

4Department of Endocrinology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.



Gestational transient thyrotoxicosis (GTT) is a transient, mild hyperthyroidism that occurs early in pregnancy and is due to human chorionic gonadotropin. There is no clear information about why only some pregnant women develop GTT. Previous papers stated that vitamin D plays a role in thyroid functions. We aimed to evaluate the relationship between vitamin D and GTT.


Fifty-three patients diagnosed with GTT at the 6th to 10th weeks of gestation were included in the study (GTT group). Thirty-five pregnant women with normal thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) levels served as a control group. Vitamin D, TSH, fT3, and fT4 levels were followed during entire the pregnancy.


TSH levels had been normalized at the 20th week of gestation in all patients with GTT (mean TSH: 0.56 ± 0.2 μIU/mL). Vitamin D levels were significantly lower in the GTT group than the controls (11.1 ± 7.7 and 16.5 ± 0.5 ng/mL, respectively; P = 0.008).


Pregnant women who are diagnosed with GTT should be evaluated for possible vitamin D deficiency.


Gestational transient thyrotoxicosis; pregnancy; vitamin D

PMID: 27966300

DOI: 10.3906/sag-1507-33


1 Reply

Having a clean up of unanswered posts. :)



You may also like...