So the short of it, I have depression that is ruining my life. I'm ok in the am about 2 hours then all I want to do is sleep. I have gained 50 lbs. I am on the following meds: Adderall 60mg day, Pristiq 50mg day, Synthroid 137 mcg day. Subtotal thyroidectomy 2001 to remove goiter rt side of neck. Now one is growing on lt. My TPO antibodies were high but MD never did anything. My main concern is no quality of life. I also take xanax 0.5mg prn for anxiety which is at least once per day. Have tried many things over the years and nothing works. Any suggestions?