The patient information leaflet for my asthma inhaler (symbicort) has a warning about taking care if taking it with levothyroxine. Does anyone here know why this is? I am currently going through a really wheezy patch which I don't seem to be able to find a reason for. It started about a week before I started to slowly increase my levothyroxine as I have been feeling really really tired and weepy. I am going up to 100 mg and am currently on 87.5 up from 75 three weeks ago. The asthma doctor wants me to increase my symbicort to twice a day but this seems to make the wheezy worse (I take the steroid without the long acting beta part as pulmicort twice a day as well). I follow a very strict lifestyle and diet which works mostly most of the time but not at the moment! I have a medical history of not tolerating the asthma drugs well (I seem to react to all phenolics including salbutamol (ventolin)) and I am generally really suspicious of these drugs. I also take montelukast which was very successful when I first took it over 5 years ago but less so now and I worry about the long term effects of this one. My ferratin, vitamin d, folate and B12 are all mid or top of range now but I was insufficient in b12 last year and vitamin d back in April. I have chronic nose and sinus problems and no sense of smell at all as well as fatigue and horrible sore bones and as for the weepiness!