We've Won!: A little time ago I said that one of... - Thyroid UK

Thyroid UK

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We've Won!

diogenes profile image
diogenesRemembering
50 Replies

A little time ago I said that one of our papers was in a competition in a scientific journal for the best paper in there over a 4 year period since the journal started. With your help and support, we have won this competition, and out of 12 papers, ours received over one third of the votes. I take this opportunity to thank all those who supported us in voting. The outcome is that the paper will feature in the September Newsletter of the journal, and also I believe will give it much more publicity. To remind you the paper was about the variability in the human response to thyroxine therapy stemming from the variation originally found in the population in health. This leads inevitably to a minority of patients needing more than just T4 to achieve some sort of optimum treatment i.e. T3.

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diogenes profile image
diogenes
Remembering
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50 Replies
loueldhen profile image
loueldhen

Fantastic. Well done this community and you of course! Slowly but surely and hopefully.

waveylines profile image
waveylines

Congradulations Diogenes -well earnt!! And any publicity which draws doctors attention to this problem is just wonderfull. Really appreciate all your hard work.

humanbean profile image
humanbean

Wonderful news, and a well-deserved win!

Fantastic so well done!

greygoose profile image
greygoose

Oh, very well done! And well deserved, too!

nightingale-56 profile image
nightingale-56

Congratulations! So glad we have got you on our side.

shaws profile image
shawsAdministrator

Brilliant and all of you good scientists deserve praise. Plodding on trying to get the 'proof' published and being awarded the Best Paper in four years. Champions - no doubt about that :)

helvella profile image
helvellaAdministratorThyroid UK

Couldn't be happier if I had won it myself!

diogenes profile image
diogenesRemembering

Hope so too. Unfortunately there's jealousy swimming around. He pointedly has never quoted any of our work in his publications, though we quote his in ours. The green-eyed god lives well in academic medicine I'm afraid.

LindaC profile image
LindaC in reply to diogenes

Oh it certainly does ;-) Well done indeed!

dolphin5 profile image
dolphin5

Well done!!!! I don't know where we'd be without your work - my endocrinologist always seems very eager to get hold of your papers. Keep up the good work!!

DellFinium profile image
DellFinium

Congratulations, Diogenes - we all have much to be thankful for.

SilverAvocado profile image
SilverAvocado

Congratulation and thanks so much for the work you do :)

stiltzski profile image
stiltzski

Many congratulations. A fantastic result.

Helena93 profile image
Helena93

Congratulations and thank you so much for all your essential hard work and perseverance.

( My A&E Doctor last week "What's T3?" )

Clutter profile image
Clutter

Diogenes,

Congratulations! I am grateful to you and your colleagues for illustrating that T4 is not sufficient for all patients.

diogenes profile image
diogenesRemembering

I know this is odd replying to myself, but I'd just like to share a thought which was drummed into me by my first supervisor when I started out being a serious scientist a long long time ago (physical biochemist then!). He said "In any problem, there are millions of ways to be wholly wrong and only one way to be wholly right. If you can bear the odds against you then you can truly call yourself a scientist". And I hope I've held to that all my working life.

waveylines profile image
waveylines in reply to diogenes

Hi Diogenes -what wise words......its a real shame that most doctors dont hold the same view -if they would stop regarding hypothyroidism as simple to treat with a one solution med delivered against pretty rigid criteria we might just get somewhere! ! Thank goodness for your hard work chipping away at this myth! Thank you 😊😊

Trixie64 profile image
Trixie64

Congratulations - that's wonderful!

Pookie50 profile image
Pookie50

Congratulations! You deserve it for all your hard work. Hopefully it will be widely read by the medical profession.

shambles profile image
shambles

Love the excitement in your tone :-). So very well deserved too. A big thank you from me for finding the 'wholly right'.

Salsa2014 profile image
Salsa2014

Brilliant! Thank you so much.

Rapunzel profile image
Rapunzel

Ave Diogenes !

< Passes over laurel wreath >

I doubt that the green eyed god will sleep; there is a certain professor who is doubtless preparing his foaming refutation as I write.

We must just keep on b*ggering on and hope for our children

Airmed profile image
Airmed in reply to Rapunzel

Don't take any notice of the egotistical green eyed monster. He and his like minded colleagues who insist that we don't need T3 are an excuse of a scientist in my book. I wish they, endocrinologists and doctors alike who are of the same opinion could have a day in my life before T3. I guarantee they would change view overnight. I just wish they would put up or shut up and remember that people's lives are affected by their unfounded views. Theory and reality do not always run along hand in hand. Would have thought any scientist worth his or her salt would know that. Keep up the great work.

diogenes profile image
diogenesRemembering in reply to Airmed

I'm not indicating in my criticism of Bianco's actions that he doesn't agree with us. His group work with rats and mice to discover thyroid control mechanisms and the influence of T3 is clear. It would then be natural for others to follow on quoting from his work in later human studies. But unfortunately the time sequence is wrong; we've found out additional concepts in human studies before he has found them in rats, so his group's thunder is stolen rather. It's this that I think has led to the ignoring of others' work if it is tending to predate him. There is also the regrettable "exceptionalism" in American thinking when it comes to science, not just medicine but especially so there. This leads to something of a gulf between the USA and e.g. Europe when it comes to cross-referencing and priority quoting. The USA feeds on itself in this respect much more than Europe.

Nanaedake profile image
Nanaedake

Can't wait to read it!

Cariad-y-Mor profile image
Cariad-y-Mor

What brilliant news☺

Well done on your achievement, so deserving. Thank you for your continuing efforts to open the eyes of the Establishment.

crimple profile image
crimple

Thanks for all your hard work and congrats on your success. Let's hope there will be more successes leading to better treatment of thyroid patients.

galathea profile image
galathea

Brilliant news, Congratulations. Now all we have to do us get the buggers to listen and learn. Xx

humanbean profile image
humanbean

I think another common flaw is that T3 is "over-valued". People have too big a chunk of their T4 taken away and replaced by too small a dose of T3.

I did find one article (an old one from the 70s) where the opposite fault occurred. The replacement was done on a 1 to 1 basis. 20mcg of T4 was replaced by 20mcg of T3. Most of the subjects ended up being overdosed and felt terrible. Another unjustified strike against T3...

Dollychris profile image
Dollychris

Congratulations on this wonderful news. So well deserved!

Canta profile image
Canta

Congratulations, Diogenes. Hopefully your research will lead to patients receiving more individualized treatment, rather than having to suffer a 'one size fits all' dictate.

linda96 profile image
linda96

Well done, Diogenes. Hopefully, things will turn around for t3. Perhaps a national daily will take the news and take it to a wider audience. I'm ever hopeful!

Silverlady5 profile image
Silverlady5

Congratulations Diogenes all your hard work is paying off x

AliF profile image
AliF

Could you send me the details and a link to the journal and the newsletter. I might be able to give it even more publicity. DM me if you prefer

diogenes profile image
diogenesRemembering in reply to AliF

Our best and complete review of this can be dowloaded from this site:

In Google, type "Frontiers in Thyroid Endocrinology". A page will come up. Select the first item and click on it. A new page will appear. Select the item saying "most viewed". A review by us will then come up which you can download.

diogenes profile image
diogenesRemembering in reply to AliF

The actual article is in "Endocrine Connections" which is a free -to-view journal. The newsletter isn't out yet I believe. Click on Endocrine Connections in Google and go on from there.

AliF profile image
AliF in reply to diogenes

Thanks Diogenes

Musicmonkey profile image
Musicmonkey

Great news!! Congratulations and may you have many more successes. 😊

SAMBS profile image
SAMBS

Diogenes you can't imagine how pleased I am to read your post! Well done to you all!

SAMBS profile image
SAMBS

Eljii. - I like your reply above and would add again my own words that we are ALL Individuals - each with different health histories and complications which I therefore deduce means ......

individual combinations of Thyroxine Plus whatever works best in order for our bodies to make best use of it.

Already I am of the opinion that the HPT axis is the most complicated and misunderstood part of our systems! I know that to my own cost now - with my health history.

2 weeks ago my Haematologist said he thought my Thyroid was the root cause of years of slowly emerging bone deformities. So slowly I almost thought nothing of any of it over the years, despite 3 corrective surgeries to one foot! It's also happening in my fingers. I could give you & Diogenes enough info to write an Encyclopedia! !

helbell profile image
helbell

Well done!!

Airmed profile image
Airmed

Fantastic. Well done everyone.

sunny-64 profile image
sunny-64

YAY !! RESULT ,well done ,soooo nice to get something positive

LindaC profile image
LindaC

Great news diogenes - keep on truckin'... up that crazy river - thank you :-)

Coastwalker profile image
Coastwalker

Thank Q diogenes. X

Crazy_CatLady profile image
Crazy_CatLady

Well done! What is the title or PMID of the article? I'd love to read it. I'm also a scientist :-)

diogenes profile image
diogenesRemembering in reply to Crazy_CatLady

See my replies to AliF above. Follow the instructions there and you'll soon find the articles. The first author in both is Hoermann R.

spongecat profile image
spongecat

Only just seen this news. Congratulations! :D

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