At one and the same time we see two papers. First, the one discussed in this very recent post here:
A new paper provoking strong negative responses on Twitter.
healthunlocked.com/thyroidu....
Second, this one which has slipped behind the endocrinology wall into cardiology.
Thy and mighty: the importance of T3 thyroid hormone on dyadic structure and function in cardiac health and disease
Cardiac dyads facilitate efficient calcium (Ca?+)-induced Ca* release and thus excitation-contraction (EC) coupling in the heart. Although transverse (t)-tubules provide the structural basis for dyad formation by ensuring close apposition of sarcolemmal L-type Ca? * channels (LTCCs) and ryanodine receptors (RyRs) of the sarcoplasmic reticulum (SR) Ca+store, nanoscale organization of these Ca?* channels within dyads is also of major importance. Several proteins have been identified as having key roles in dyadic regulation, and there is increasing evidence that thyroid hormones (TH), particularly bioactive triiodothyronine (T3), are critical modulators of these proteins (1, 2). Recently in this journal, Charest et al. (3) highlighted the importance of TH on RyR clustering and the association between RyRs and the dyad-spanning protein junctophilin-2 (JPH2). They demonstrated that TH deficiency results in fewer, less closely spaced RyR clusters that have fewer colocalizations with LTCCs and JPH2; and that supplementation with T3 ameliorates these effects. Considering its role in t-tubule maturation (4), this emphasizes the significance of TH in both macro- and nanoscale dyadic organization, and the potential compounding effects of abnormal TH levels on dyadic dysfunction.
Link shows rest of first page - as a poor quality image that is barely readable. And the rest is behind a paywall.
journals.physiology.org/doi...
One saying liothyronine is over-prescribed and largely not justified. In the other that T3 supplementation works! Do you think the authors of the first have any idea that the second exists?
With apologies to Frankie:
When two papers go to war
A point is all that you can score
Score no more! Score no more!
