I am trying to find some answers for my daughter who has Hashi's and Addison's and only a couple of years ago had low iron and needed supplementation. Now she has normal ferritin, high serum iron and high saturation. She does not take any iron supplements of any kind and has little in the way of red meat - trying to lower her levels. Her last results were:-
ferritin 138ug/L (30-250)
iron 32umol/L (8-30)
transferrin 2.41g/L (2-4)
saturation 53% (10-35)
Strangely enough she feels as though she is low on iron and her MCV and MCHC readings are low in range.
She has methylation issues which means she has trouble detoxing heavy metals and we know she is high in copper as a result. There is some research to show that as the body needs to deal with copper first, iron levels can rise in the process.
I haven't helped much but am also interested in any ideas to help understand what may be going on. Thank you 
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Jenny,
Sorry to hear of your daughters health problems and how annoying to have supplemented too much iron which is notoriously hard to lower. Monitoring iron levels can be difficult as doctors are reluctant to test too often and the body can bring unexpected results.
Your daughters MTHFR issues might have influenced the copper level. I too have detoxification issues and had a high copper and zinc deficiency last year. These work together and the ratio is important but by supplementing zinc & high levels of Vit C this has rebalanced my levels.
Your daughter may have issues with other heavy metals. Further testing proved elevated platinum and mercury (& other metals to a lesser degree) and so the instigation to remove all amalgam fillings followed by 6 months of chelation. I still drink apple pectin, etc, in my water to manage unbound heavy metals as the detoxification issues mean it an ongoing problem.
Copper is especially disruptive to the adrenal glands and can lower neurotransmitters in the brain. Last year I supplemented 5-HTP and am now on HRT for depression which has thankfully now lifted. Iron, selenium, zinc and copper are all heavily involved with thyroid function and I now find my meds (T4 & T3) working much better.
Some foods contain more copper but I didn’t worry about these as already follow a diet suited to Hashimotos (gluten & virtually grain free) and keeping iron levels low as suffer Haemochromotosis (iron overload).
Vit C, beta carotene & alcohol all have an enhancing effect on iron absorption. Heme iron (meat) is more easily absorbed than non-heme iron (beans, spinach, fortified cereals). Tannins in tea//coffee can reduce absorption of non-heme. Legumes & grains (phytates) & calcium hinder iron absorption. Some people avoid red meats completely but a glass of milk with a Spaghetti Bolognese topped with cheese will inhibit iron absorption. Following these protocols I have managed my high iron levels and not required the monthly theraputic phlebotomy for 4 months but am due to start again soon... ahhhh ! ! ! ...
I have found the addition of plentiful protein has helped thyroid hormone synthesis enormously. I supplement copious amounts of Vit C for adrenal health and continued heavy metal detoxification, but take the whole lot at night. Not ideal but it keeps it well away from foods. I also eat & supplement plentiful antioxidants.
High iron levels can make me feel as if I have low iron levels too (breathlessness and low energy). I hope your daughter feels better soon.
Thank you Radd and I am glad to hear that your health is improving. Depression alone is a terrible illness to suffer from let alone all of the other issues. Some really great info too. My daughter is incredibly disciplined in her approach, following an autoimmune protocol diet, good proteins, low carb, low copper and generally avoids alcohol. I think the underlying issue, as you mentioned, is the methylation problems, which we have to address very slowly. I hope your path to optimised health continues progressing.
Thank you jenny,
There are many sups known to help with our MTHFR issues. For instance I am on bioidentical hormones (HRT) and take DIM and CA D-Glucarate to help metabolise and excrete oestrogen's correctly.
It may be worth exploring probiotics as well. Some gut flora has the ability to block heavy metal absorption whilst dysbiosis encourages further absorption and inhibits proper detoxification. Copper toxicity can lower gut acid (as can low thyroid hormone) and slow oxidisers (liver activity) retain metals very easily due to a sluggish metabolism making it harder to excrete. A mutation on the CBS gene (cystathionine beta synthase) can also effect the methyl groups and toxic metal excretion.
I supplement Methylfolate and Methylocobalamin with a B complex.
I wish your daughter well.
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Gut Flora & Metals
tvernonlac.com/gutflora.html
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Heavy Metal Detoxification & probiotics.
aem.asm.org/content/78/18/6...
Thank you for sharing your wealth of knowledge. I will have a read of the links you provided. Take care