I am losing count of the number of times we have seen T3 (liothyronine) mentioned in diseases other than the classic thyroid disorders.
[Please everyone, I really don't understand this abstract or anything much else. It is the irony that I have referred to before - it feels as if the only specialists who won't be using liothyronine will be endocrinologists.]
Oncoimmunology. 2015 Jul 1;5(1):e1064579.
The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity.
Alamino VA1, Montesinos MM1, Rabinovich GA2, Pellizas CG1.
Author information
1Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET) and Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba, Argentina.
2Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME-CONICET) and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires, Argentina.
Abstract
Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.
KEYWORDS:
Cancer vaccination; dendritic cell; immunotherapy; thyroid hormone; triiodothyronine
PMID: 26942081 [PubMed]
ncbi.nlm.nih.gov/pubmed/269...
More information about dendritic cells and cancer: