The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity

I am losing count of the number of times we have seen T3 (liothyronine) mentioned in diseases other than the classic thyroid disorders.

[Please everyone, I really don't understand this abstract or anything much else. It is the irony that I have referred to before - it feels as if the only specialists who won't be using liothyronine will be endocrinologists.]

Oncoimmunology. 2015 Jul 1;5(1):e1064579.

The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity.

Alamino VA1, Montesinos MM1, Rabinovich GA2, Pellizas CG1.

Author information

1Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET) and Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba , Córdoba, Argentina.

2Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME-CONICET) and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Buenos Aires, Argentina.

Abstract

Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.

KEYWORDS:

Cancer vaccination; dendritic cell; immunotherapy; thyroid hormone; triiodothyronine

PMID: 26942081 [PubMed]

ncbi.nlm.nih.gov/pubmed/269...

More information about dendritic cells and cancer:

dendritic.info/

2 Replies

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  • Helvella, it may as well be written in Spanish for what I understood other than Liothyronine, as you point out, appears to be seen as beneficial by all sorts of doctors other than endocrinologists.

  • Dendrite cells are communicators and are essential in immune response pathways. Equally so, healthy levels of thyroid hormones play an important role in this process because thyroid hormones are essential for growth, differentiation and metabolism in immune system regulation. This study highlights the importance of T3 in promoting T cell (helper) activity , providing evidence to aid development in cancer vaccines however, immune cell response affects every system in our bodies which is why we feel so bad when our thyroid function is not optimal.

    Only when the medical profession starts to investigate, treat and understand thyroid disease in holistic terms, do we as suffers have a chance of controlling our symptons, prevent damage to other organs, and pre-empt flare-ups.

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