Here we go again!!
I've just read an article and one of the phrases struck home:
“Levothyroxine is the most perfect hormone replacement that has yet been devised for endocrine conditions, but there are undoubtedly people who fall outside the current treatment model. Animal-derived products that contain T4 and T3 are not physiological and are not the answer in the longer term, but we do need to find ways to ensure that all our patients with hypothyroidism feel the full benefits of replacement therapy.”
The ETA concluded that there was insufficient evidence to show that combination treatment is more effective than monotherapy. Having considered the factors that have been linked to persistent symptoms in the presence of adequate biochemical control of hypothyroidism, the ETA recommended that endocrinologists should reassure patients about their condition and support them in coming to terms with a chronic disease requiring life-long medication.
The T4/T3 ratio stated in the article is:-
When combination treatment is considered appropriate, the ETA suggests that treatment should be started in a L-T4/L-T3 dose ratio between 13:1 and 20:1 by weight, and that L-T3 should be divided in two doses (one before breakfast and the largest one at bedtime).
whereas another study below recommends (page 80)
Subsequent research by the US National Institutes of Health
(NIH) found the therapeutic equivalence was 3:1. Thus, most of the subjects were under treated with the T3/T4 combination. In light of the NIH finding, the conclusion that T3 therapy is never needed is invalid.
In the article no mention is made about the possibility of the DIO2 (deiodinase 2 gene). preventing the uptake of T3. Nothing about thyroid hormone resistance (they may not think that's possible). We already know that the statement is by a doctor who would rather diagnose a 'Somatization Disorder' than attempt to give the sick patient an alternative when bloods show the 'exquisite' TSH is in range.
A sensible, responsible response in the BMJ