I have been posting on here for many years now due to the fact that I was diagnosed with hypothyroidism in 2007 and to date although I have been told by endo's that I have tried every thyroxine and NDT on the planet as well as various T3 I have not been able to tolerate any of them, I believe this is due to allergies but I am fighting at the moment to get this investigated by an Immunologist. The reason I am confused is because over the last 7 years the highest my TSH has reached was 13.4 in May last year. This year I changed GP and they did the usual thyroid tests and in January my TSH was 40.32, T4 was low at 10.3 . In April TSH was 7.66, T4 13.3 and my TPO was 271 (ref range <101 is normal). Last week I had blood tests during a consultation with my endo and he sent me a letter today saying that my TSH is 4.55 and that there is no need to worry about getting me onto thyroid meds, I assume because he didn't mention T4, T3 or TPO that they must have been normal or he would have mentioned them. As you can imagine having had a diagnosis in 2007 and never having been on any meds for longer than 2 weeks I really do not feel well at all. I just do not understand why my TSH is going up and down and my TPO antibodies which have always been around 10 suddenly shot up to 271 last month and now it's normal again. Can any of you very knowledgeable people help me make sense of this please because I am totally at a loss. Many thanks to you all.