I've been taking NDT for a few years, now. Firstly I took it with breakfast, as Dr P does along with everything else; then I took it sublingually because of advice here on the site; then I took it on an empty stomach with water 1 hour before eating - because of advice on here; now I take it by chewing it and swallowing with water on an empty stomach 1 hour before eating because of advice ....
I haven't noticed much of a difference but I think, to be honest, that's more about not taking the correct dosage for me, which seems to be a never-ending bl***y saga. I'm not sure, unless near-enough the correct dosage has been attained, if such fine-tuning will be discernible.
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