Forskolin and cAMP
From an Ayurvedic Herb
Forskolin also has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release. This mechanism of stimulating the thyroid to enhance metabolism may be one way in which Forskolin promotes normal body weight. Forskolin's effects in normalizing thyroid function may also contribute to its antidepressant effects, as depression is a common feature of hypothyroidism.
Forskolin stimulation of thyroid secretion of T4 and T3.
Forskolin is a potent activator of adenylate cyclase in many tissues including the thyroid gland. Forskolin is a potent activator of adenylate cyclase in many tissues including the thyroid gland. We compared the effects of 10(-5) M forskolin and 100 mu units/ml TSH on the dynamics of T4 and T3 secretion from perfused dog thyroid lobes. Both agents induced pronounced increases in T4 and T3 secretion. The increase in secretion was significantly steeper during forskolin than during TSH stimulation. This may suggest that early processes such as TSH-receptor interaction and the subsequent activation of the catalytic unit of adenylate cyclase are of importance for the pattern of very gradual increase in hormone secretion during TSH stimulation of the thyroid. In other respects forskolin seems to induce absolute and relative secretion of T3 and T4 very similar to those obtained by cAMP and TSH.
Forskolin (also called Coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin resensitizes cell receptors[dubious – discuss] by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP. cAMP is an important signal carrier necessary for the proper biological response of cells to hormones and other extracellular signals. IT IS REQUIRED FOR CELL COMMUNICATION IN THE HYPOTHALAMUS / PITUITARY GLAND AXIS AND FOR THE FEEDBACK CONTROL OF HORMONES. Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac. Further reading: function of protein kinase A
Forskolin has been shown to increase cAMP formation in all eukaryotic cells except sperm, without hormonal activation of adenylate cyclase.  Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release,  lowers blood pressure  and IOP,  inhibits platelet aggregation, , promotes vasodilation, , bronchodilation,  and thyroid hormone secretion, , and stimulates lipolysis in fat cells.  Forskolin also has a positive inotropic action on cardiac tissue via increased cAMP levels.  The cAMP level is important for retinal ganglion cells neurotrophic responsiveness to neurotrophins which is important for neuron survival. cAMP may inhibit some forms of neurotrophin-mediated neuronal survival and suggests that a number of PI3-kinase-regulated processes in neurons may be inhibited by cAMP.