Can taking levothroxine at night cause insomnia?

I have an under active thyroid and after reading comments on here I started taking my medication at night. I am feeling much better and my recent blood test revealed that my tsh has reduced to 0.8 from 1.8, which I am pleased about. The problem is I have developed insomnia over the last week and I am hot and restless all night resulting in lack of sleep. Could it be the levothyroxine or is it just a coincidence? I'm thinking I may have to go back to taking my medication on a morning. I take 50mg.

12 Replies

  • Not sure if it does affect sleeping, but I take mine at night and have very restless nights. I have kind of got used to it now and prefer to take it at night so as not to interfere with other medication. Maybe worth thinking of changing back to mornings and see if you sleep better. good luck x

  • Like you I take 50 levo. which apparently is a low dose so presumably we don't need much. I can feel the effects within a couple of hours so taking it at night def. keeps me awake. I take mine when I first wake-up around 7am.

  • Hi I would make sure your vit D, hormonal is OK as often gives these symptoms. If low you need a corrected calcium test before a script, best way through Endo or GP.

    Best wishes,


  • hi. Im on 100mg levo - i started taking it at night shortly after i began taking it. Previous to that i suffered from insomnia. It has made no difference to my insomnia at all but it is so much easier to take at night.

    You might consider getting your adrenals checked; I did and apparently have high night time cortisol.....the only advice they could give me was to get better sleep .... /-:

  • I tried nightime and it was a dreadful week of no sleep so i went back to early morning. sleep is not great but much better than when i took it at night.

  • I agree, night time didn't suit me either, I changed back after about a week too.

  • It is a trial and error situation for each and every one, i sleep a lot better taking mine at night and i take 200mcg but it doesn't suit everyone. I find it much easier too it means i can take my supplements in the morning without worrying about wether i can take them with my levo and i no longer have to check every cereal i might want to buy for added vitamins and minerals

  • Levothyroxine generally advised mornings.

  • I was advised by endo to take mine at night too as I'm sensitive to any slight change and she thought I would absorb it better! I felt terrible, restless and had palpitations.....felt hyper as opposed to hypo and I have hashimotos so know the difference between the two extremes. Couldn't sleep so I changed back to mornings on the same dose and was better.

  • Thanks guys, sorry for late reply, I've been away over the weekend. I started taking levo on a night while away and now I'm sleeping like a baby again. I preferred taking it on a night as it was a lot more convenient as mentioned but it obviously it did not agree with me. Thank you again for your replies they are much appreciated.

  • Taking it on a morning again, dam brain fog!!!

  • hi there

    I have been having trouble sleeping too and hot,restless only thing that changed was amount 75 to 100 and taking it at night so i too may try going back to morns

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