I am always cold, my reflexes were tested and found to be almost non-existent, I'm on daily medication for constipation and I'm gaining weight despite a 1000cal/day strict diet for the last 2 years. My T4 was 32.5, then 28, now 24. My doctor wants me to take PTU but I'm really reluctant to as I think they'll make my symptoms even worse. I also have none of the symptoms of hyperthyroidism and other doctors I've seen have been baffled. I did take carbimazole for a while but stopped because of the side effects. I was so cold I had to sit in a hot bath all day and felt like I was dying, no energy at all. Wish I'd never taken them but although my doctor agrees that I have no signs of hyperthyroidism, she only seems to care about the test results and keeps telling me to start the medication again. I'd rather just leave things alone. Any advice/opinions would be much appreciated.