Prucalopride advice.

[Steakhouse]

Has any one been on Prucalopride and found it stopped working after a while? It was a life saver for two years for me, but everything is grinding to a halt again and the bloating is horrendous. I stopped it for two weeks and started back three days ago. Lots of rumblings and passing stool maybe not fully, but bloating still bad and constant. Any advice anyone? Also I read it might help to stop and start it, but maybe I’m too intolerant?

Thank you in advance.

[25clai]

Funnily enough, I do have some advice. I was on Prucalopride for 10 months and then it started to be less and less effective in managing my symptoms.

Unlike you , I didn’t realise at the time it wasn’t working, as I had so many problems going on.

About a month back I was referred to a gastroenterologist, who suggested changing the med to another one similar to Prucalopride. She told me they would both work better if they are swapped over every 2 months .

I am about halfway through Linotadine, the other drug prescribed, which works well for me

suggest you go to your gp and discuss a change of meds.

[Steakhouse in reply to 25clai]

Thank you so much! I’ll do that ☺️

[Steakhouse in reply to 25clai]

It is called Linaclotide ( constella) btw? 🤔

[edwangy in reply to Steakhouse]

they act in different ways, linoclotide softens the stool by drawing water into the colon, it can cause diarrea and cramps. I have to take it every day but it's better than being constipated. Prucalopride stimulates peristalsis, helping to speed up the flow through the gut

[Steakhouse in reply to edwangy]

Ah. I’m not so great with softeners, bloat and diarrhoea. I haven’t tried this one so I’ll live in hope 🤞Thanks for reply and best luck ☺️

[Kazzacrazy]

I've been on it for a few years. Sometimes it didn't work as well, so I took a stool softener, which helped. I only take half a day now as cancer treatment makes me the other way most days 🫣 I hope you find something that works for you.

[Steakhouse in reply to Kazzacrazy]

Ah, it’s a hard balancing act isn’t it 🙁 Thank you for your reply and very best wishes to you ☺️

[Lovemyfamily89]

I’ve been on it for 4.5 years now but I take it every night along with bisacodyl. I believe it’s still working. I can flex the amount of bisacodyl up, if I feel sluggish and back down when things are working as they should, so I’m not sure if I would know if the prucalopride was working as well as it should be it not. When I originally took it on its own, it didn’t help much.

[Steakhouse in reply to Lovemyfamily89]

That’s interesting, thank you! . It’s all just trial and error alas it seems, and I worry that laxities can stop your bowel functioning at all over time 🫤

[Lovemyfamily89 in reply to Steakhouse]

Yes that’s true. I think I can assume that has already happened to me, as I’ve been on bowel medication since I was just a few days old but as long as the meds work, that’s better than the options I’ve been given. Good luck with it all 👍