Prucalopride and Depression

[jeao]

Hi,

Has anyone experienced worsening depression while taking prucalopride (Resolor, Resotran, Motegrity)? I’ve been on it for almost two months and while it does help immensely with constipation, I’ve also lost my motivation, I feel hopeless and sad all the time and I cry a lot. I just don’t feel like myself. Anyone else?

[AmandaJW]

I felt exactly the same as you when I was taking it, it wasn't working for me so my doc took me off it and I felt much better.

[Love_vodka]

Hi I just started taking this last week and have felt really tearful. Im on 2mg daily. It is working a little, but not sure if it’s the right thing for me long term.

Can I ask what you are taking now?

[SlowT1]

Yes me too. It makes me feel really tearful and I feel like i just want to stay in bed x

[Love_vodka in reply to SlowT1]

Are you still taking it or have you found something else?

[SlowT1 in reply to Love_vodka]

I got through cycles of taking different laxatives to try and manage side effects. I’m currently taking Dulcolax and senakot, but whatever I take I always feel constipated, bloated and in pain. I am considering sacral nerve stimulation or the ACE procedure. I have tried irrigation but it just didn’t work for me. Have you tried linacolotide? That didn’t work for me but I hear it does for some people.

[Eliana5]

Hi, I think if you Google "Pruculopride", it's a bit similar to an SSRI antidepressants. Although I thought Motegrity was was the same thing as Zofran(?) that they took off shelves and off market in 2005..and it just got re-approved for use on April 1st. One is a laxative (Zofran..it starts with a c but can't think of the name at the moment) and Pruculopride was not? But the Pruculopride has serotonin in it..so unless you have been diagnosed with depression is why you feel you might be sad on it. Can you give it a few more weeks? x

[jeao]

Interesting and good to know I’m not the only one. I knew that prucalopride works by stimulating serotonin receptors and of course, serotonin is linked to mood. So it was a nice side effect at first that my mood seemed to mellow from my anxious, high-strung state. (I work full-time and share custody of my two young daughters, so stress is my constant companion).

However, my mood got so low I ended up feeling really depressed. Too much of a good thing, I guess. I’ve cut my dose to 1mg per day but I don’t think it’s helping the digestive symptoms as much. I’ve also read that SSRIs can ease constipation as a side effect and some doctors prescribe it for that reason. Perhaps I’ll look into that. Or maybe just switch to Constella? Or maybe it wasn’t Resotran at all that caused my low mood and just life and monthly hormones colliding in an awful way? So many variables that it’s hard to figure out the right path.