Resolor/ prucalopride experience : Hi I was... - IBS Network

IBS Network

48,748 members16,076 posts

Resolor/ prucalopride experience

Love_vodka profile image
16 Replies

Hi

I was prescribed Resolor 2mg 1 tablet 2 weeks ago. I had side effects for about 2/3 days. Headache, nausea and then the side effects wore off and around day 4 they stopped working.

I’ve continued to take them as they worked fantastically the first couple of days and I’m praying for a miracle.

Last night I took 4mg, so double dose and today they worked and I was able to have a bm... yay :)

Unsure whether they are going to work any more than a couple of days, seeing consultant tomorrow so will ask if they will officially up the dose.

Anyone take 4mg? Is it usual for them to stop working so quickly?

Written by
Love_vodka profile image
Love_vodka
To view profiles and participate in discussions please or .
Read more about...
16 Replies
claire_louise profile image
claire_louise

Hi, I had the same experience with Resolor and my consultant told me to try taking them every few days instead (like you would a laxative). This worked great, although it means your body doesn't get used to the side effects. I suffered with them a fair bit but decided it was worth it for the relief I got.

Love_vodka profile image
Love_vodka in reply toclaire_louise

Thanks Claire I will definitely try this. The consultant suggested one daily and then 4mg when needed. I think it’s just a bit of trial and error and what best works for you. Thanks for your help xx

claire_louise profile image
claire_louise in reply toLove_vodka

No problem! I used to take it a couple of times a week and found it was the only medication that helped me have a 'natural' bowel movement. It really worked wonders for me, although the side effects weren't nice. You might also need to play around with the dosage a little bit to see what works best for you - I'm very slim so only needed 0.5-1mg! But everyone is different.

Love_vodka profile image
Love_vodka in reply toclaire_louise

Weirdly I had a few days feeling sick and now no side effects at all. I’m a size 8, they work better than anything else so far because it’s just like a normal bm but the 4mg def works better than 2mg for me.Are you still taking them or have you found something else?

Thanks again! So nice when other people get what’s happening xx

claire_louise profile image
claire_louise in reply toLove_vodka

The side effects will wear off if you're taking it every day, but if you only take it intermittently they do hit you unfortunately. I took it for a good few years before my symptoms changed and it stopped working for me. That was down to other underlying issues though and I still credit Resolor with turning my life around for a good while.

Love_vodka profile image
Love_vodka in reply toclaire_louise

Are you in the UK Claire?

Do you suffer from slow transit?

I’ll try next week taking a bit more intermittently and see what the results are like.

What do you take now?

claire_louise profile image
claire_louise in reply toLove_vodka

Hi, yes I'm in the UK. No slow transit, just chronic constipation (has been VERY chronic at times). I have a long and complicated history but currently I don't take any laxatives, after having a stool analysis 2 years ago and being treated for a variety of things including Candida and parasites. This has helped my constipation no end, but I've had a lot of setbacks and am still undergoing treatment to improve my other symptoms (incredibly debilitating pain, gas etc).

Love_vodka profile image
Love_vodka in reply toclaire_louise

Whereabouts are you in UK?

I have slow transit and bowel prolapse, recently diagnosed so just trying to find ways to manage it successfully. I have a lot of unexplained pelvic pain too.

It’s good to hear you have some of your symptoms under control. Do you follow any special diets.

Thank you for your help Claire xx

claire_louise profile image
claire_louise in reply toLove_vodka

No problem :) So sorry to hear you're going through all that. I've tried many diets over the last 10 years or so! Fodmap and gluten free didn't work for me but many people do have success with those. I'm dairy intolerant so don't eat that and I also follow a low sugar diet following treatment for Candida (which involves zero sugar for several months). I'm in the East Midlands, where abouts are you?

Love_vodka profile image
Love_vodka in reply toclaire_louise

Hi Claire sorry for delay in reply,hope you’re doing well I’ve been away in Scotland for a week.

I’m in Harrogate North Yorkshire. Been taking your advice and having breaks with the resolor and so far so good. Just started low FODMAP to see if that helps.

Zero sugar sounds painful :/

claire_louise profile image
claire_louise in reply toLove_vodka

No problem, hope you had a lovely time! Zero sugar is tough, you have to be very strict or it doesn't work. That means cutting every single grain of sugar, including natural sugar like fruit and honey, and even sugar coated painkillers! It was a revelation though as I realised just how much I was eating and now manage quite happily on much, much less.

So glad the prucalopride is working out for you! 😊 How are the side effects?

Love_vodka profile image
Love_vodka in reply toclaire_louise

Wow! Well done! Sounds hardcore! I’d be screwed as have 2 spoons in coffee :/

The side effects are varied, sometimes doesn’t bother me, sometimes I’m zonked or emotional, feel like it’s worth it at the moment and hopefully I can get a balance which fits with my work/life.

Are you managing your symptoms? Are you working at the moment?

claire_louise profile image
claire_louise in reply toLove_vodka

I used to find that too, sometimes I'd be ok-ish and other times I couldn't get out of bed, but the overall improvement was definitely worth it.

I'm still going through treatment so the struggle is real lol. Haven't been able to work for 3 years now. I keep getting setbacks but I'm hopeful that I'll get there eventually. My nutritional therapist is fantastic and has helped me so much more than the NHS ever did.

Love_vodka profile image
Love_vodka in reply toclaire_louise

Do you pay privately for a therapist? I might consider if things don’t improve over the next few months.

Sorry to hear your unable to work, it sounds like you’ve had a real struggle. I hope things continue to improve for you and thank you for taking the time to help me with your experience xx

nomoreibsc profile image
nomoreibsc in reply toLove_vodka

Thank you for this message feed. On resolor too and was having side effects. I found the tips so helpful and will be trying them. I have constipation, slow transit and weak pelvic floor muscles. Experiencing acid reflux, asthma, sinus issues which I think is related to the IBS c. Struggling to get back to work too. May try a natural health practitioner. Hope you found a way to balance the side effects of resolor.

nomoreibsc profile image
nomoreibsc in reply toclaire_louise

Thank you for all your tips. So helpful. Having issues with finding the right balance of taking laxative and resolor, and side effects. Experiencing similar issues to you. How did you get tested for candidia?

Not what you're looking for?

You may also like...

Resolor/prucalopride

My gastroenterologist has given me these to try instead of relying on laxatives. Over the last year...
Megnstan profile image

Resolor (prucalopride) good or bad?

Does anyone have any experiences with Resolor ( Prucalopride) that they could share with me? I have...

Prucalopride

I’ve been taking Prucalopride for about 8 months now , it worked like magic initially, but over...

prucalopride

hi everyone! my doctor has recently put me on 2 mg of prucalopride(resolor) for chronic...
improving profile image

prucalopride - Tips

Hi Have been suffering with chronic constipation for that last 2 years, plus pain in the pelvic...

Moderation team

IBSNetwork profile image
IBSNetworkPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.