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M1774 plus Niraparib clinical trial
hi , has anyone been in the trial of M1774 either in its own or with Niraparib ? I have just been offered this at the Royal Marsden . Any feedback would be greatly appreciated!! Enjoy your Christmas all . Hopefully we can all forget about the big C for one day !!! x x
hi , has anyone been in the trial of M1774 either in its own or with Niraparib ? I have just been offered this at the Royal Marsden . Any feedback would be greatly appreciated!! Enjoy your Christmas all . Hopefully we can all forget about the big C for one day !!! x x
Lookingahead
in
My Ovacome
2 years ago
Any ideas on blood labs to monitor for earlier detection than PSA for becoming Castrate Resistant?
I am trying to get an idea of better test labs markers besides just the usual PSA for becoming castrat resistant, because if my SOC of ADT (Orgovyx, and Nubeqa) is starting to fail I would want to immediately jump on BAT. My doc always adds LDH. Conclusion: Our analysis suggested the association
I am trying to get an idea of better test labs markers besides just the usual PSA for becoming castrat resistant, because if my SOC of ADT (Orgovyx, and Nubeqa) is starting to fail I would want to immediately jump on BAT. My doc always adds LDH. Conclusion: Our analysis suggested the association
KocoPr
in
Advanced Prostate Cancer
2 years ago
Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson’s Disease: A Review
Abstract Neurodegenerative disease is a collective term given for the clinical condition, which results in progressive degeneration of neurons and the loss of functions associated with the affected brain region. Apart from the increase in age, neurodegenerative diseases are also partly affected by diet
Abstract Neurodegenerative disease is a collective term given for the clinical condition, which results in progressive degeneration of neurons and the loss of functions associated with the affected brain region. Apart from the increase in age, neurodegenerative diseases are also partly affected by diet
Thal
in
Cure Parkinson's
2 years ago
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BITE Clinical Study
My husband was told he only has two treatment options at this point. One is starting Jevtana, but at a lower than normal dose due to his neutrophils being only 1150. The other would be to participate in a clinical trial called BITE in Louisville. I am afraid I don’t recall what BITE is an acronym for
My husband was told he only has two treatment options at this point. One is starting Jevtana, but at a lower than normal dose due to his neutrophils being only 1150. The other would be to participate in a clinical trial called BITE in Louisville. I am afraid I don’t recall what BITE is an acronym for
Wyldhare22
in
Advanced Prostate Cancer
2 years ago
New drug approved for those with KRAS G-12C
On December 12th, 2022, the Food and Drug Administration (FDA) approved Krazati (adagrasib) for treatment of non-small cell lung cancer (nsclc) where there is a KRAS G12C mutation. This approval is for patients who have received at least one line of prior treatment such as chemotherapy. The FDA based
On December 12th, 2022, the Food and Drug Administration (FDA) approved Krazati (adagrasib) for treatment of non-small cell lung cancer (nsclc) where there is a KRAS G12C mutation. This approval is for patients who have received at least one line of prior treatment such as chemotherapy. The FDA based
Miranda_GO2
Partner
in
Lung Cancer Support
2 years ago
Urso blocks COVID - research today from Addenbrooke's Hospital, Cambridge
15h Dec 2022 at 14:15 UK time : On the BBC World Service programme Healthcheck, right now. Liver consultant from Addenbrooke's reporting that they have discovered that Urso protects against COVID. Medic says that Urso blocks COVID's ability to enter human cells. 'It shuts the doorway (into the cell
15h Dec 2022 at 14:15 UK time : On the BBC World Service programme Healthcheck, right now. Liver consultant from Addenbrooke's reporting that they have discovered that Urso protects against COVID. Medic says that Urso blocks COVID's ability to enter human cells. 'It shuts the doorway (into the cell
Wilderswimmer
in
PBCers Organization
2 years ago
Delivery of mRNA therapies: Moderna's founder Bob Langer discusses past, present, and future
[i]"mRNA is expected to become one of the major pillars of drug development. With an increasing number of concepts entering clinical trials, the first approval of an mRNA therapeutic against cancer is nearing" [/i]are the concluding lines of a review paper published in April 2021 https://molecular-cancer.biomedcentral.com
[i]"mRNA is expected to become one of the major pillars of drug development. With an increasing number of concepts entering clinical trials, the first approval of an mRNA therapeutic against cancer is nearing" [/i]are the concluding lines of a review paper published in April 2021 https://molecular-cancer.biomedcentral.com
bennevisplace
in
CLL Support
2 years ago
The Vaccines are coming[b] [/b]
https://www.yahoo.com/now/moderna-merck-announce-mrna-4157-120000391.html Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial Moderna, Inc. Tue,
https://www.yahoo.com/now/moderna-merck-announce-mrna-4157-120000391.html Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial Moderna, Inc. Tue,
Scout4answers
in
Advanced Prostate Cancer
2 years ago
18 Month Update
Brief Summary Gleason 4+5 with Intraductal histology T3b n1 Brca2. After 18 months of ADT plus Abiraterone and HDR Brachytherapy and EBRT my WBC is within normal limits for the first time since HDR Brachytherapy. My PSA started at 10.28 and decreased 95% the first month of ADT and slowly after that
Brief Summary Gleason 4+5 with Intraductal histology T3b n1 Brca2. After 18 months of ADT plus Abiraterone and HDR Brachytherapy and EBRT my WBC is within normal limits for the first time since HDR Brachytherapy. My PSA started at 10.28 and decreased 95% the first month of ADT and slowly after that
TylexGP
in
Advanced Prostate Cancer
2 years ago
Starting my prostate cancer journey after radical prostatectomy. Looking for info, suggestions or recommendations on future treatments.
Hello everyone, I am 67 and had a PSA of 8.9 and a grade group 4 Gleason score of 4+4=8. I had radical prostatectomy with lymph node dissection on 12/1/2022. I am on the road to recovery. The pathology report showed 60-70 % of prostate involved by tumor with extraprostatic extension present, non
Hello everyone, I am 67 and had a PSA of 8.9 and a grade group 4 Gleason score of 4+4=8. I had radical prostatectomy with lymph node dissection on 12/1/2022. I am on the road to recovery. The pathology report showed 60-70 % of prostate involved by tumor with extraprostatic extension present, non
MrDexter
in
Advanced Prostate Cancer
2 years ago
Experimental cancer therapy shows success in more than 70% of patients in global clinical trials
Myeloma is only cancer mentioned https://medicalxpress.com/news/2022-12-experimental-cancer-therapy-success-patients.html?utm_source=join1440&utm_medium=email&utm_placement=newsletter
Myeloma is only cancer mentioned https://medicalxpress.com/news/2022-12-experimental-cancer-therapy-success-patients.html?utm_source=join1440&utm_medium=email&utm_placement=newsletter
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Fine-Tuning the Wave of Innovation in CLL
ASH2022 is happening in New Orleans, right now. Yesterday, there was a great webinar hosted on the PeerView platform that covered Personalized Models for Upfront and Sequential Care With Groundbreaking Treatment, which should be of interest to anyone contemplating firstline or relapsed/refractory treatment
ASH2022 is happening in New Orleans, right now. Yesterday, there was a great webinar hosted on the PeerView platform that covered Personalized Models for Upfront and Sequential Care With Groundbreaking Treatment, which should be of interest to anyone contemplating firstline or relapsed/refractory treatment
SeymourB
in
CLL Support
2 years ago
Treatment of Richter's syndrome - ASH 2022 Education Program
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
This year's American Society of Hematology (ASH) annual conference is now underway and the ASH Education Program, Volume 2022, Issue 1 booklet that was published on 9 December 2022 is now available at: https://ashpublications.org/hematology/issue/2022/1 It contains three review articles from sessions
CLLerinOz
Administrator
in
CLL Support
2 years ago
Lu-177 as SOC vs Clinical Trial
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
Many thanks to all contributors! Since I've now just had my 16th cabazitazel/carboplatin chemo treatment, we're looking at options and working on Lu-177. I'm curious that, since Lu-177 is now FDA approved and is Standard Of Care, is there an advantage to seeking a clinical trial vs receiving it as
MechD
in
Advanced Prostate Cancer
2 years ago
New drug for treating hot flashes under FDA review
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
This article appeared in Natl Geographic's online daily. Because it is behind a paywall, I have copied it below. While the drug is primarily intended for menopausal women, the article notes that future beneficiaries could include men taking drugs for prostate cancer. Is it possible to cure hot
garyjp9
in
Advanced Prostate Cancer
2 years ago
Chemo/Pluvicto or Clinical Trial?
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
I have stage 4, mcrpc with mets to pelvic lymph nodes and prostate. ADT (Firmagon and Zytiga) kept PSA undetectable for ~2.5 years, then PSA started to rise. I had radiation to prostate in March of this year, which did not help. I started a clinical trial in October at NYU (LAVA 1207 immunotherapy)
carguy
in
Advanced Prostate Cancer
2 years ago
Glycine : said to reduce symptoms and reduce aggregation
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
https://www.michaeljfox.org/grant/modulation-glycine-treatment-parkinsons-disease Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity
Little_apple
in
Cure Parkinson's
2 years ago
Details of Inhibikase Trial Suspension
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
Many of us have been following Inhibikase and the recent suspension of trials by the FDA. Inhibikase just issued a press release regarding the concerns expressed by the FDA. "The FDA raised several points, summarized below, in their explanation of the basis for the clinical hold: Further evaluation of
jimcaster
in
Cure Parkinson's
2 years ago
An exciting new clinical trial called STEM-PD is due to start in Sweden and the UK for Parkinson’s.
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
The symptoms of Parkinson’s are caused by the loss of dopamine-producing nerve cells or neurons in the brain; and researchers have long proposed using cell transplantation as a treatment option for replacing these lost dopamine cells. One challenge presented to research teams however has been generating
Farooqji
in
Cure Parkinson's
2 years ago
Bionic chip reveals how some antibiotics can harm kidneys
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
[i]
From left, Amir Livne, Dr. Gil Shamai and Prof. Ron Kimmel, the computer scientists who developed the neural network that examines breast cancer scans. Photo courtesy of the Technion – Israel Institute of Technology
[/i] Breakthrough technology blends sensors and human tissue in a smart kidney
lupus-support1
Administrator
in
LUpus Patients Understanding and Support
2 years ago
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