The Vaccines are coming[b] [/b] - Advanced Prostate...

Advanced Prostate Cancer

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The Vaccines are coming[b] [/b]

Moderna and Merck Announce mRNA-4157/V940, an Investigational Personalized mRNA Cancer Vaccine, in Combination with KEYTRUDA(R) (pembrolizumab), Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial

Moderna, Inc.

Tue, December 13, 2022 at 6:00 AM·43 min read

Moderna, Inc.

mRNA-4157/V940, in combination with KEYTRUDA, demonstrated a statistically significant and clinically meaningful reduction in the risk of disease recurrence or death compared to KEYTRUDA monotherapy in stage III/IV melanoma patients with high risk of recurrence following complete resection

Results are the first demonstration of efficacy for an investigational mRNA cancer treatment in a randomized clinical trial

Companies plan to discuss results with regulatory authorities and initiate a Phase 3 study in melanoma in 2023 and rapidly expand to additional tumor types

CAMBRIDGE, MA and RAHWAY, NJ / ACCESSWIRE / December 13, 2022 / Moderna, Inc. (NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, and Merck (NYSE:MRK), known as MSD outside of the United States and Canada, today announced that the Phase 2b KEYNOTE-942/mRNA-4157-P201 trial of mRNA-4157/V940, an investigational personalized mRNA cancer vaccine, in combination with KEYTRUDA®, Merck's anti-PD-1 therapy, demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of recurrence-free survival (RFS) versus KEYTRUDA alone for the adjuvant treatment of patients with stage III/IV melanoma following complete resection. Adjuvant treatment with mRNA-4157/V940 in combination with KEYTRUDA reduced the risk of recurrence or death by 44% (HR=0.56 [95% CI, 0.31-1.08]; one-sided p-value=0.0266) compared with KEYTRUDA alone.

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15 Replies

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GSDF2 years ago

Nice research work brother 🙏👍

Scout4answers• in reply toGSDF2 years ago

thanks a cure is coming from somewhere

Scout4answers• in reply toGSDF2 years ago

looking at your profile, looks like Orgovyx and Xtandi are working well for you

GSDF2 years ago

I feel same but doctor fears xtandi has now run it's course as he sees 3 straight months of PSA remaining at 2, to which he feels should be continuing to fall to undetectable, whereas I feel I'm doing good because I still have a prostate this is the first time in years I e had a steady, low and holding PSA.... So of course I'm concerned by his concern 🙂

pakb• in reply toGSDF2 years ago

My husband is over 5 years in to this. G9, initial PSA 677, mets to multiple bones, just reached PSA of 1. Has steadily gone down fir over 5 yrs- some small blips up but no trend up- and scans look good. He feels good too. Works, active, etc. It was the same number months in a row a few times in the last 5 years.

Scout4answers• in reply toGSDF2 years ago

holding steady and low sound good to me

tango652 years ago

Thanks for posting. I hope something similar may work with PC. Melanoma is a solid tumor which responds well to immunotherapy. Unfortunately PC is the opposite.

Adendino• in reply totango652 years ago

Aren’t most prostate cancers considered “solid” tumors?

tango65• in reply toAdendino2 years ago

Yes. PC as a solid tumor is the opposite to melanoma in the sense that PC has a poor response to immunotherapy.

Sorry by the confusion. Here, in Timbuktu we do not handle english very well.

samuelachglue19522 years ago

Moderna stock POPPED at this announcement.

DaveBSD2 years ago

Ironically, many of us in the United States don't handle English well, either. (Or even England!)

Rolphs2 years ago

From what I’ve read it’s likely that any “cure” of PCa will come from vaccines. The work Moderna did quickly producing a VAC for Covid 19 was amazing. If they can use the same RNA manipulation to attack cancer we all have reason to hope.🎄

BB_12 years ago

I do not trust these companies and the FDA.

Rolphs• in reply toBB_12 years ago

Interesting take on this. IMHO Moderna and other drug companies saved millions of lives by delivering pretty effective vaccines in record time. I haven't heard about their products "killing and harming" people to any degree more than the typical vaccine in development. Everyone complains about drug companies greedy, products too expensive, unsafe etc. Not me, it's 100% I'd be dead now without their drugs. What's your alternative for treating cancer? BTW, I agree with you about the FDA but that's another topic.

Cheers!