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A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations
An experimental drug reported in Nature Communications suggests that a “path is clearly achievable” to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes about 11 percent of cystic fibrosis patients, as well as patients with other genetic diseases
An experimental drug reported in Nature Communications suggests that a “path is clearly achievable” to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations. This includes about 11 percent of cystic fibrosis patients, as well as patients with other genetic diseases
2greys
in
Lung Conditions Community Forum
3 years ago
Fatigue--Side effects of Ursodiol?
Hi I am new to this forum and grateful that it exists. I have just been diagnosed with PBC (early stage) and was put on Ursodiol. I am 62 and otherwise really healthy and fit. Yet at this point. I am really struggling with fatigue (and occasional dizzy spells) and wondering if anybody else experienced
Hi I am new to this forum and grateful that it exists. I have just been diagnosed with PBC (early stage) and was put on Ursodiol. I am 62 and otherwise really healthy and fit. Yet at this point. I am really struggling with fatigue (and occasional dizzy spells) and wondering if anybody else experienced
Knoesel
in
PBCers Organization
3 years ago
Please can you look at my results and advise?
I recently asked my GP for a full Thyroid test, as I am so tired all of the time. I booked a test for 7.30am, and missed my dose of Thyroxine the night before. TSH 2.6 (0.27-4.20) FT4 16.3 (12.0-22.0) FT3 4.2 (3.1-6.8) Peroxidase Antibodies 5kIU/L (<34)
I recently asked my GP for a full Thyroid test, as I am so tired all of the time. I booked a test for 7.30am, and missed my dose of Thyroxine the night before. TSH 2.6 (0.27-4.20) FT4 16.3 (12.0-22.0) FT3 4.2 (3.1-6.8) Peroxidase Antibodies 5kIU/L (<34)
Juliana88
in
Thyroid UK
3 years ago
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PD and Depression
My mama has had PD for over 15 years and a fall a few years ago , with a C2 fracture put her on bed . The thing is that the doctors gave up on her. She had a nasal tube for 4 months which messed up her swallowing and hence her speech . I remember even after the accident in the hospital she was talking
My mama has had PD for over 15 years and a fall a few years ago , with a C2 fracture put her on bed . The thing is that the doctors gave up on her. She had a nasal tube for 4 months which messed up her swallowing and hence her speech . I remember even after the accident in the hospital she was talking
mymomhaspd
in
Cure Parkinson's
3 years ago
Help… advised to go on alendronic acid
Had a dexa scan. GP sent a message by mobile phone to say she had been told by rheumatologist to start me on alendronic acid. Advised to have dental check and that is it. No advice or help in deciding if I want to take it. I have had in the past very bad indigestion problems abs really don’t want to
Had a dexa scan. GP sent a message by mobile phone to say she had been told by rheumatologist to start me on alendronic acid. Advised to have dental check and that is it. No advice or help in deciding if I want to take it. I have had in the past very bad indigestion problems abs really don’t want to
Reddev
in
PMRGCAuk
3 years ago
Ashermans, thin lining, low ovarian reserve, poor responder.. trying ivf one last time with donor sperm for possible surrogacy if lucky
After many years of having a Mirena coil for heavy periods, my then partner and I decided to start to try for a baby. I thought it was strange that when I had the coil out my periods remained just as light as when I had it in. I decided to do some hormone tests, and discovered I had a high prolactin
After many years of having a Mirena coil for heavy periods, my then partner and I decided to start to try for a baby. I thought it was strange that when I had the coil out my periods remained just as light as when I had it in. I decided to do some hormone tests, and discovered I had a high prolactin
Hidden
in
Infertility Support
3 years ago
Medication for af and heart failure
I have been put on by Cardiology at Stoke Bisoprolol 5mg twice per day Plus Degoxin 0.187mg per day and Entresto 24/26 twice per day. I also take 10mg of Zolpidem around 2am in the night as I always wake up in middle of the night due to sleep disturbance of my heart medications. The Zolpidem works
I have been put on by Cardiology at Stoke Bisoprolol 5mg twice per day Plus Degoxin 0.187mg per day and Entresto 24/26 twice per day. I also take 10mg of Zolpidem around 2am in the night as I always wake up in middle of the night due to sleep disturbance of my heart medications. The Zolpidem works
Mike-tyson
in
British Heart Foundation
3 years ago
Symptoms but no diagnosis. Frustrating. I've tried everything and would appreciate any kind of advice. Please note this is a very long post.
I started to feel discomfort on the right side below my ribs about a year and a half ago. It wasn't pain as such but more of a discomfort that one should not feel daily. I was drinking heavily at the time; beer, whiskey, tequila. This discomfort has now become chronic that would last for a few hours
I started to feel discomfort on the right side below my ribs about a year and a half ago. It wasn't pain as such but more of a discomfort that one should not feel daily. I was drinking heavily at the time; beer, whiskey, tequila. This discomfort has now become chronic that would last for a few hours
Wantobehealthy
in
British Liver Trust
3 years ago
Ashermans syndrome, endometrium 2.5mm, poor responder, trying ICSI one last time for surrogacy
Hi everyone, I’ve started a short protocol this week 450 Ovaleap to combine with Menopur from day 8 to try and get a blastocyst to freeze for potential surrogacy After many years of having a Mirena coil for heavy periods, my then partner and I decided to start to try for a baby. I thought it was strange
Hi everyone, I’ve started a short protocol this week 450 Ovaleap to combine with Menopur from day 8 to try and get a blastocyst to freeze for potential surrogacy After many years of having a Mirena coil for heavy periods, my then partner and I decided to start to try for a baby. I thought it was strange
Hidden
in
Fertility Network UK
3 years ago
Bone medication
I have been taking Ibandronic acid for a few years now for brittle bones due to years of Lupus meds. Recently my new dentist made a point of saying that they look out for it on people’s records as it causes teeth and jaw problems!! My friend just had the same reaction from her dentist. What’s going
I have been taking Ibandronic acid for a few years now for brittle bones due to years of Lupus meds. Recently my new dentist made a point of saying that they look out for it on people’s records as it causes teeth and jaw problems!! My friend just had the same reaction from her dentist. What’s going
DaisyMeadows
in
LUPUS UK
3 years ago
Alendronic Acid and migraines
Has anyone had migraines associated with alendronic acid? I took AA for 3 weeks and then stopped (with GP blessing - see other posts). I was diagnosed with ocular migraines about 3 years ago and had a very occasional one. They are migraines with an aura and all the associated blind spots and weird visual
Has anyone had migraines associated with alendronic acid? I took AA for 3 weeks and then stopped (with GP blessing - see other posts). I was diagnosed with ocular migraines about 3 years ago and had a very occasional one. They are migraines with an aura and all the associated blind spots and weird visual
Mo51
in
Bone Health and Osteoporosis UK
3 years ago
Dexa scan results
Bit distraught. Got my dexa results today and it appears I have osteopenia throughout the lumber spine and total hip with osteoporosis of femoral neck. Wish I'd taken the flipping alendronic acid now! What now? Is any of this reversible? Feeling very tearful, please help.
Bit distraught. Got my dexa results today and it appears I have osteopenia throughout the lumber spine and total hip with osteoporosis of femoral neck. Wish I'd taken the flipping alendronic acid now! What now? Is any of this reversible? Feeling very tearful, please help.
artisam
in
PMRGCAuk
3 years ago
ALA & ALCAR
Acido alfa lipoico y acetil l carnitina.
Acido alfa lipoico y acetil l carnitina.
Paralelo
in
Cure Parkinson's
3 years ago
AlA & ALCA
Hello everyone. My question is can AlA and ALCAR be taken together with l/c, or does it have to be taken separately? I get very tired exercising. Thank you. Jesus
Hello everyone. My question is can AlA and ALCAR be taken together with l/c, or does it have to be taken separately? I get very tired exercising. Thank you. Jesus
Paralelo
in
Cure Parkinson's
3 years ago
Magnesium Supplements
I'm taking 350mg soluble magnesium carbonate every other day, as suggested by my GP before I was diagnosed. However, I have read that Magnesium Glycinate is specifically recommended for absorption and also as a sleep aid of sorts. Would welcome any feedback - i.e. what dose should be taken daily
I'm taking 350mg soluble magnesium carbonate every other day, as suggested by my GP before I was diagnosed. However, I have read that Magnesium Glycinate is specifically recommended for absorption and also as a sleep aid of sorts. Would welcome any feedback - i.e. what dose should be taken daily
Pr0jection
in
PMRGCAuk
3 years ago
Higher levels of omega 3 increase longevity according to an 11 year study.
Hi everyone, Unfortunately busy life styles and multi tasking has taken its toll on the diets of many as convenience and fast foods are consumed at the detriment to our overall health. As sadly lots of fast foods are high in calories yet low in nutrients so we have to realise that food is our fuel it's
Hi everyone, Unfortunately busy life styles and multi tasking has taken its toll on the diets of many as convenience and fast foods are consumed at the detriment to our overall health. As sadly lots of fast foods are high in calories yet low in nutrients so we have to realise that food is our fuel it's
Hidden
Administrator
in
Healthy Eating
3 years ago
Advice needed
To frightened to take ibandronic acid for my diagnosis of Osteoporosis.
To frightened to take ibandronic acid for my diagnosis of Osteoporosis.
JulDeb7374
in
Bone Health and Osteoporosis UK
3 years ago
Results are in can have people's opinions
TSH 24 Free T3 9 Vit D 28mg Iron 28mg Blood Sugar 6.2 Cholesterol 2.6/5.1 LFT/ KFT/B12 (good GP didn't give the results over the phone) After a 40 min conversation I know have Vitamin D tablets, Statins, Blood Pressure medication and contacting
TSH 24 Free T3 9 Vit D 28mg Iron 28mg Blood Sugar 6.2 Cholesterol 2.6/5.1 LFT/ KFT/B12 (good GP didn't give the results over the phone) After a 40 min conversation I know have Vitamin D tablets, Statins, Blood Pressure medication and contacting
Bunnyjones
in
Thyroid UK
3 years ago
Spinal compression
I have recently sadly sustained another spinal compression which is really painful this time. Not helped by the fact it has taken my doctors so long to sort out medication for me. I had my first in August last year and I’ve still not started on any programme after failing to get along with alendronic
I have recently sadly sustained another spinal compression which is really painful this time. Not helped by the fact it has taken my doctors so long to sort out medication for me. I had my first in August last year and I’ve still not started on any programme after failing to get along with alendronic
philippa1412
in
Bone Health and Osteoporosis UK
3 years ago
Book "Let Food be your medicine" by Don Colbert, MD
He covers a number of common illnesses. I only summarise what I consider the main points from the section on cancer with the hope of stimulating discussion. He does not claim to cure cancer and says "but it does help, and we have helped hundreds of patients treat (manage or control) their cancer".
He covers a number of common illnesses. I only summarise what I consider the main points from the section on cancer with the hope of stimulating discussion. He does not claim to cure cancer and says "but it does help, and we have helped hundreds of patients treat (manage or control) their cancer".
Graham49
in
Advanced Prostate Cancer
3 years ago
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