Experiences with

Thyrotropin-releasing hormone

An interesting paper in many ways. The association of TRab with Alopecia Areata; The understanding of the issues of TRab and Graves - stimulating and others; The sex differences discussed; And the establishment of a closer-than-ever link between thyroid and Alopecia Areata including recommendations

ASCO GU 2025: New Study Tries to Identify Key Factors That Influence How Quickly Prostate Cancer Becomes Resistant to Hormone Therapy Androgen deprivation therapy (ADT) is the foundation of treatment for advanced prostate cancer, but many patients eventually develop castration-resistant prostate cancer

With all the limits of a retrospective study (otherwise I might almost become depressed...) A real-world study of 41,379 prostate cancer patients found that GnRH antagonists lead to faster castration resistance than LHRH agonists, with a median time to CRPC of 10.9 vs. 17.3 months (HR 1.40, p=0.02).

hi all! I have endometriosis and diffuz adenomyosis ( i had a surgery with specialist and 3 months gnrh before the transfer) only left an embrio with 2BB grading. ( i know not the best grading but we implanted) is it any way for success I am completely devasted…..

Hi all. I'm sure there are experienced as well as newcomers working their way through PC. I guess I am an 87 year old ; somewhere between the two. My PC was discovered nearly 8 months ago. PSA was about 12 as I remember and both checks showed cancer and it was decided to take drugs to reduce the prostate

Hi, I have been suffering with very heavy periods and pain for the last few years, it’s took around 18 months to see a gynaecologist and be diagnosed with uterine fibroids, since then various treatments have been tried including oral contraceptives, mirena coil, provera and more recently GNRH injections

Hi, I'm trying to find someone else in a similar situation. I had 4 monthly injections of GnRH as a temporary form of relief for my endometriosis whilst I waited for my follow up Gynae appointment. My last injection was in September and my period still hasn't returned? Is this normal? I was told my periods

Good morning, im looking for advice regarding the GNRH injection, I've not had a diagnosis of endometriosis as my gynaecologist has suggested trying this injection or going straight in to do a oophorectomy, he says the likelihood of endometriosis is high going by my symptoms and my overies are fused

Hi I have been back and forth to gynecologist for over 5 years now i have endometriosis and more recently have been diagnosed with endometrial hyperplasia with cysts and cystic spaces, today I had an appointment to go through treatment. Due to having a laparoscopy only a year ago they don't really want

Summary Paragraph: The study examines testosterone recovery (TR) in prostate cancer patients undergoing androgen deprivation therapy (ADT) in conjunction with radiotherapy, as assessed across multiple randomized trials by the MARCAP Consortium. Variabilities in TR were identified based on ADT

Since April my psa has started to rise with monthly results below; April 0.03 May 0.05 June 0.07 August 0.53 October 5.0 November 36 December 8.0 after 2 weeks of Bicalutamide. I had the following PET x 3 and MRI x 2 (full body) scans from 0.5 upwards. The first 2 PET scans and first MRI did

I was diagnosed in 2012 with Hashi's Hypothyroidism and struggled for over a decade to get an Endo who would work with my persistent low FT3. Unfortunately, my (sharp young bright female) Endo who understood that a low TSH is normal with combination therapy has moved away. I have been given to new young

Well, I have not searched about this for long, but while I wait to see if estrogen patches will be approved in europe for metastatic cancer, I am having doubts about switching from triptorelin (which did and is still doing its job) to relugolix. I know my MO first instinct will be saying "if it's working

A potentially important issue for some people. And one that is 100% ignored when dentists say we should not rinse after brushing. Even if we do rinse after some time, it is likely that we will swallow some of the calcium ingredients (if our toothpaste contains any). Despite being written as a paediatric

"Compliance" with meds taking and timing is a big issue, as we all know. And research shows that especially with the elderly, compliance to meds regimes and timings by day and by week is difficult to follow. And the consequences are not good. When one is on doublet therapy (whether or not one had also

Hi all, Okay my first post… always suffered from painful periods remember being sent to the medical room at school for belly aches. Yet after having my daughter at 24 I became anaemic from months of bleeding and have suffered since. Been on iron supplements for the past 20 years. The odd internal

If you search this forum, you can find 52 posts which mention "cataract" - and several gave rise to significant discussions. Search if you wish: https://healthunlocked.com/thyroiduk/search/posts?query=cataract I'm not sure how much "proof" this paper provides of a link. But it certainly points a finger

Unless I missed it, I haven't seen a post about the anticipated-this-fall results of the PATCH Study. I just noticed that it was reported out at the ESMO meeting a couple of weeks ago. They noted "key takeaways" to include: **Transdermal estradiol is as effective as LHRH agonist and there is no detriment

[i]This recent research paper in Nature is potentially ground-breaking for the understanding of essential mechanisms involved with bone health. It's findings are related to hormonal changes during the start of mid-pregnancy lactation and early newborn nurturing that could possibly lay the foundation

Hi ladies I am hopeless and devastated so down spirited I found many useful posts here thought I share my concerns with you if anyone have similar experiences to share I really appreciate although my case might be very rare due to having adenomyosis removed- normally its being treated only with