An interesting paper in many ways.
The association of TRab with Alopecia Areata;
The understanding of the issues of TRab and Graves - stimulating and others;
The sex differences discussed;
And the establishment of a closer-than-ever link between thyroid and Alopecia Areata including recommendations.
In terms of treatment, not much progress. But we often need to understand before treatments can be developed. And this appears to be a step in that direction.
Prevalence of Thyrotropin Receptor Antibodies and Clinical Profile of Patients with Alopecia Areata: A Cross-Sectional Study
Subject Area: Dermatology
Athanasios J. Stefanis; Alena Fialova; Petr Arenberger
Skin Appendage Disord (2025) 11 (1): 1–8.
Abstract
Introduction: Alopecia areata (AA) is associated with thyroid dysfunction and abnormal levels of thyroglobulin and thyroid peroxidase autoantibodies. One study detected high prevalence of thyrotropin receptor antibodies (TRAbs) in AA patients. Our aim was to investigate the prevalence of TRAb levels in AA patients and to assess their association with thyroid hormones, other thyroid antibodies, AA severity, and other epidemiological variables. Methods: In this observational study, 139 patients (97 females, 42 males), aged 12 and above, with newly presenting, relapsing, or treatment-resistant AA were included. Medical histories were reviewed, alopecia severity was assessed using the Severity of Alopecia Tool (SALT), and blood tests measured thyroid hormones and autoantibodies. Results: The prevalence of TRAb was significantly higher in AA patients (23.6%) compared to the general population (1–2%) (p < 0.001). Elevated TRAb titers did not correlate with diagnosed thyroid dysfunction or treatment, abnormal thyroid function tests and autoantibodies, AA severity, duration, and onset. Male patients exhibited a significantly higher prevalence of abnormal TRAb titers compared to females (75.0% vs. 21.3%, p = 0.002). Conclusion: A significant proportion of AA patients presented with elevated TRAb levels, independent of thyroid hormone titers, other thyroid autoantibodies, or SALT score. Prevalence of abnormal TRAb levels was higher in males.
Journal Section:
Research Article
Keywords:
Thyrotropin receptor antibodies, Alopecia areata, Cross-sectional study, Thyrotropin receptor antibody, Thyroid autoantibodies
Open access:
karger.com/sad/article/11/1...
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