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Prostate-specific antigen (PSA)
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Arx517 updates about the trial for metastatic castration resistant prostate cancer
”Following completion of the 21-day observation period at 3.4 mg/kg (Cohort 9), no dose limiting toxicities (DLTs) or serious adverse events (SAEs) were observed Two patients in Cohort 9 experienced rapid
PSA
reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com
”Following completion of the 21-day observation period at 3.4 mg/kg (Cohort 9), no dose limiting toxicities (DLTs) or serious adverse events (SAEs) were observed Two patients in Cohort 9 experienced rapid
PSA
reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com
Maxone73
in
Advanced Prostate Cancer
9 months ago
5 months after stopping the 4 mos of taking orgovyx still very symptomatic of low t (miserable)..told t may never recover (79),take trt? ?
still worried that the saturation theory re: trt and
psa
is still not discredited and many docs still think TESTOSTERONE still can trigger a RECURRENCE?? All responses welcome.. 68,
psa
.2, psma pet -no mets, ece, 20 imrt, 4 mos orgovyx finished 5/28/23 ,
still worried that the saturation theory re: trt and
psa
is still not discredited and many docs still think TESTOSTERONE still can trigger a RECURRENCE?? All responses welcome.. 68,
psa
.2, psma pet -no mets, ece, 20 imrt, 4 mos orgovyx finished 5/28/23 ,
JWS13
in
Advanced Prostate Cancer
10 months ago
Scared, Uninspired looks Triple Negative Breast Cancer Aggressive Cancer, what’s next?
To add insult to injury, my husband was diagnosed in June 2022 with Stage 4 Advanced Metastatic Prostate Cancer, his
psa
is rising, just a battle… Now Me with Breast Cancer Unbelievable, I can’t believe this is Our Life.
To add insult to injury, my husband was diagnosed in June 2022 with Stage 4 Advanced Metastatic Prostate Cancer, his
psa
is rising, just a battle… Now Me with Breast Cancer Unbelievable, I can’t believe this is Our Life.
JaM6252005
in
SHARE Breast Cancer Support
7 months ago
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Adding Docetaxel to T3b?
PSA
is currently .04. So far, so good, BUT... I'm wondering if there is more we should be doing in lieu of all his high risk factors to prevent a recurrence or metastasis down the road.
PSA
is currently .04. So far, so good, BUT... I'm wondering if there is more we should be doing in lieu of all his high risk factors to prevent a recurrence or metastasis down the road.
Adendino
in
Advanced Prostate Cancer
8 months ago
Just completed a whole gland TULSA procedure
This was salvage treatment after failure of SBRT by MRIdian in Mar 2020.
PSA
nadir after SBRT was 2.4 and it rose to 5.3 just 3 years later, when a PSMA scan showed 2 possible tumours within the gland. A subsequent biopsy confirmed local tumour recurrence with Gleason 4+4.
This was salvage treatment after failure of SBRT by MRIdian in Mar 2020.
PSA
nadir after SBRT was 2.4 and it rose to 5.3 just 3 years later, when a PSMA scan showed 2 possible tumours within the gland. A subsequent biopsy confirmed local tumour recurrence with Gleason 4+4.
Packidge
in
Advanced Prostate Cancer
9 months ago
To Chemo or Not to Chemo--that is the ?
PSA
: 9/25/23 = 26.6; 10/26/23 = 27.3, 11/23: 34.2; 1/5/24 = 49.9. New bone and CT scans 1/24/24 shows disease is progressing though changes are not enormous. I just don't know how to decide! Anybody know of resources to help me decide, or what further questions to ask? Thanks as always~~
PSA
: 9/25/23 = 26.6; 10/26/23 = 27.3, 11/23: 34.2; 1/5/24 = 49.9. New bone and CT scans 1/24/24 shows disease is progressing though changes are not enormous. I just don't know how to decide! Anybody know of resources to help me decide, or what further questions to ask? Thanks as always~~
LifeQuality
in
Advanced Prostate Cancer
7 months ago
Bicalutamide and Eligard
PSA
went up to 0.87. Doctor recommend Eligard (Lupron) with bicalutimide and dutasteride. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month.
PSA
went up to 0.87. Doctor recommend Eligard (Lupron) with bicalutimide and dutasteride. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month.
Domas
in
Advanced Prostate Cancer
7 months ago
Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
A decrease in
PSA
(prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/45 (53.3%) patients with AR LBD mutation in phase IIa.
A decrease in
PSA
(prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/45 (53.3%) patients with AR LBD mutation in phase IIa.
Maxone73
in
Advanced Prostate Cancer
8 months ago
What's next?
PSA
and it's jumped from 40 to 91. Wondering if there's any way to know if/when symptoms will start appearing due to PCa's further or worsening spread?
PSA
and it's jumped from 40 to 91. Wondering if there's any way to know if/when symptoms will start appearing due to PCa's further or worsening spread?
Shamrock46
in
Advanced Prostate Cancer
7 months ago
Ketogenic diet for High risk PCA? American Ginseng for fatigue?
Husband is Gleason 9,
PSA
46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated as high risk and following Stampede trial protocol for high risk localized PCA.
Husband is Gleason 9,
PSA
46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated as high risk and following Stampede trial protocol for high risk localized PCA.
CancerConcierge
in
Advanced Prostate Cancer
8 months ago
Following SOC here in BC Canada
Had Radium 223 and it was okay but did nothing to the
PSA
. Cancer kept progressing and had to get targeted radiation to painful spots on ribs. Started chemotherapy again and had 7 cycles of Docetaxel then switched over to cabazitaxel for 2 cycles so far.
Had Radium 223 and it was okay but did nothing to the
PSA
. Cancer kept progressing and had to get targeted radiation to painful spots on ribs. Started chemotherapy again and had 7 cycles of Docetaxel then switched over to cabazitaxel for 2 cycles so far.
Islandboy2021
in
Advanced Prostate Cancer
4 months ago
Seal49
Started with pmr diagnosed and Rheumatologist decided it is
PsA
. HD it since April. Started prednisone at 25 mg and reducing. Now at 10 mg and started on methotrexate to speed up the prednisone reduction. Rheumatologist wants it done asap.
Started with pmr diagnosed and Rheumatologist decided it is
PsA
. HD it since April. Started prednisone at 25 mg and reducing. Now at 10 mg and started on methotrexate to speed up the prednisone reduction. Rheumatologist wants it done asap.
Seal49
in
NRAS
9 months ago
abiraterone first line use in high risk in U.K. debate after stampede research results
8 months post HIFU failure, highest
PSA
was 7.
8 months post HIFU failure, highest
PSA
was 7.
SimMartin
in
Advanced Prostate Cancer
10 months ago
Looking for advice for my newly diagnosed dad
He’s had a biopsy which showed Gleason 4 +5 and his
PSA
in hospital was 54.7. So far he’s had hormone tablets for 28 days and a 3 monthly hormone shot. The oncologist first appointment gave him the option of apalutamide or doxetal with daralutamide .
He’s had a biopsy which showed Gleason 4 +5 and his
PSA
in hospital was 54.7. So far he’s had hormone tablets for 28 days and a 3 monthly hormone shot. The oncologist first appointment gave him the option of apalutamide or doxetal with daralutamide .
Springsunshi
in
Advanced Prostate Cancer
4 months ago
Estrodiol and PC
My husband has been rediagnosed with NMPC he is on ADT which is holding the Testosterone very low but
psa
shot upto 82. New MO is starting Enzalutimide plus continuing ADT. Not looking forward to the side effects, but will perservere until
psa
drops.
My husband has been rediagnosed with NMPC he is on ADT which is holding the Testosterone very low but
psa
shot upto 82. New MO is starting Enzalutimide plus continuing ADT. Not looking forward to the side effects, but will perservere until
psa
drops.
Knittingque
in
Advanced Prostate Cancer
10 months ago
Question for my father
I had my prostate removed 2 years ago at MSK and have recovered well with a still undetectable
PSA
. I’m writing for advice on my 91 yo father. He was recently found to have bone metastases throughout his skeleton.
PSA
is in the 70s.
I had my prostate removed 2 years ago at MSK and have recovered well with a still undetectable
PSA
. I’m writing for advice on my 91 yo father. He was recently found to have bone metastases throughout his skeleton.
PSA
is in the 70s.
SpecialName
in
Prostate Cancer Network
10 months ago
Urinary incontinence in mCRPC
PSA
began to rise in January 2024 with a doubling time of 3.5 weeks, metastasis increased, pain increased, and urinary incontinence presented. Moved to Zytiga in March 2024 with 5 mg prednisone twice daily Lupron injections every six months.
PSA
began to rise in January 2024 with a doubling time of 3.5 weeks, metastasis increased, pain increased, and urinary incontinence presented. Moved to Zytiga in March 2024 with 5 mg prednisone twice daily Lupron injections every six months.
lgutman
in
Advanced Prostate Cancer
4 months ago
Recurrence?
I had my
PSA
at <0.006 for several years in the same clinic but now its <0.025, is it a recurrence? Please advice.
I had my
PSA
at <0.006 for several years in the same clinic but now its <0.025, is it a recurrence? Please advice.
carlo1993
in
Advanced Prostate Cancer
10 months ago
Terrible sleep issues
My
PSA
numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot flashes. No side effects yet from the radiation. But I’m suffering terribly from very poor sleep.
My
PSA
numbers have gone from 8.4 to .2 and still falling. My side effects have been minimal , only lately have I seen some mild hot flashes. No side effects yet from the radiation. But I’m suffering terribly from very poor sleep.
Willie51
in
Prostate Cancer And Gay Men
2 months ago
Stopping Abi?
PSA
reached undetectable early in my treatment and remains undetectable. SE. aren’t fun, but manageable. Don’t know the specific SE associated with Abi vs Eligard, since treatment on each commenced at the same time.
PSA
reached undetectable early in my treatment and remains undetectable. SE. aren’t fun, but manageable. Don’t know the specific SE associated with Abi vs Eligard, since treatment on each commenced at the same time.
Gatodd
in
Advanced Prostate Cancer
8 months ago
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