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EMBARK Study: ADT vs Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Advanced Prostate Cancer
9 months ago
EMBARK Study: Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Fight Prostate Cancer
9 months ago
Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
Maxone73
in
Advanced Prostate Cancer
7 months ago
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Would I be on thin ice if I tried adaptive ADT this soon?
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
jackwfrench
in
Advanced Prostate Cancer
9 months ago
Sleep while taking Xtandi and Adt
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
JD-guy
in
Advanced Prostate Cancer
9 months ago
Ketogenic diet for High risk PCA? American Ginseng for fatigue?
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
CancerConcierge
in
Advanced Prostate Cancer
7 months ago
Too many vitamins ?
i was diagnosed 8 years ago with prostate cancer. I chose not to do anything until 4 months ago , when i felt in pain everywhere and went for treatment . I am now on Erleada and degarelix feeling much better and with the regular side effect of hot flashes and tireness. I took for 8 years and still
i was diagnosed 8 years ago with prostate cancer. I chose not to do anything until 4 months ago , when i felt in pain everywhere and went for treatment . I am now on Erleada and degarelix feeling much better and with the regular side effect of hot flashes and tireness. I took for 8 years and still
Raminagrobis
in
Advanced Prostate Cancer
10 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
7 months ago
Clinical Trial Dallas UT Southwestern
Will begin a Pfizer starting on Monday. I will post more later as it goes. We are adding a drug to Xtandi to treat solid tumors. I have been on and off Xtandi a few times. I am chemo naive. In the past had a very heavy tumor load and received 3 rounds of Lu-177 from Ishita Sen, Fortis health in Delhi
Will begin a Pfizer starting on Monday. I will post more later as it goes. We are adding a drug to Xtandi to treat solid tumors. I have been on and off Xtandi a few times. I am chemo naive. In the past had a very heavy tumor load and received 3 rounds of Lu-177 from Ishita Sen, Fortis health in Delhi
pilot52
in
Advanced Prostate Cancer
9 months ago
Getting an appointment with a renown oncologist in Chicago=Mission impossible. Is this normal?
In a comment, not long ago, about getting a second opinion, Tall_Allen suggested/gave out the name of a well known female Oncologist/Researcher in Chicago. I live here and want to give it a try. This past week called to her office and the receptionist took a long time to complete what she called an
In a comment, not long ago, about getting a second opinion, Tall_Allen suggested/gave out the name of a well known female Oncologist/Researcher in Chicago. I live here and want to give it a try. This past week called to her office and the receptionist took a long time to complete what she called an
Blueribbon63
in
Advanced Prostate Cancer
11 months ago
lots of people did this on Friday and Saturday
Dear Friends, Lots of people donated. Please consider donating too. You are acutely aware of the importance and impact of our work. Hundreds of lives have been helped—some even saved—by our prostate cancer online community's resources, suggestions, and emotional support. With this urgency, I'm reaching
Dear Friends, Lots of people donated. Please consider donating too. You are acutely aware of the importance and impact of our work. Hundreds of lives have been helped—some even saved—by our prostate cancer online community's resources, suggestions, and emotional support. With this urgency, I'm reaching
Darryl
Partner
in
Advanced Prostate Cancer
11 months ago
Keytruda - year 4
So I’m pretty much closing the book on my 4th year on Keytruda (pembroluzimab). I’ve recently completely my 33rd Pembro infusion. Keytruda was my Hail Mary after running through most other SOC. My PSA was rising while on chemo the second time when I found out I had the markers that made me eligible
So I’m pretty much closing the book on my 4th year on Keytruda (pembroluzimab). I’ve recently completely my 33rd Pembro infusion. Keytruda was my Hail Mary after running through most other SOC. My PSA was rising while on chemo the second time when I found out I had the markers that made me eligible
Chugach
in
Advanced Prostate Cancer
9 months ago
Blood in Urine
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Tonyliv
in
Advanced Prostate Cancer
7 months ago
PSA SCREEN VS SYMPTOMATIC
My current PSA test is called PROSTATE SPC AG, SCREEN. My previous PSA test from the same lab was called PROSTATE SPC AG, SYMPTOMATIC. Both labs were off the same order from my MO. Whats the difference?
My current PSA test is called PROSTATE SPC AG, SCREEN. My previous PSA test from the same lab was called PROSTATE SPC AG, SYMPTOMATIC. Both labs were off the same order from my MO. Whats the difference?
6357axbz
in
Advanced Prostate Cancer
10 months ago
Bleeding 2 weeks after first Prostap injection
Hi everyone so I currently have suspected but undiagnosed endometriosis. Dr started me on Prostap 2 weeks ago. I had been bleeding daily up until then (not a lot but noticable when I wipe) and have had lower left side pelvic pain for more than 2 years now and also have the mirena coil fitted. This
Hi everyone so I currently have suspected but undiagnosed endometriosis. Dr started me on Prostap 2 weeks ago. I had been bleeding daily up until then (not a lot but noticable when I wipe) and have had lower left side pelvic pain for more than 2 years now and also have the mirena coil fitted. This
JujuB77
in
Endometriosis UK
2 years ago
Abiraterone
Prostrate removed 2015, Savage radiation 2018, PSA went from 1.9 to 7.9 in 3 months in 2023 and bone scan and all tests show bone cancer including some lymph glands. Presently on Abiraterone and prendisone for the last 2 weeks and wonder if it works or not and looking for any comments or advise?
Prostrate removed 2015, Savage radiation 2018, PSA went from 1.9 to 7.9 in 3 months in 2023 and bone scan and all tests show bone cancer including some lymph glands. Presently on Abiraterone and prendisone for the last 2 weeks and wonder if it works or not and looking for any comments or advise?
RayKo
in
Men's Health Forum
9 months ago
How do we determine if cancer is in remission
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
GrantB47
in
Advanced Prostate Cancer
7 months ago
Has Anyone Heard that it’s More Common that Patients on Abiraterone (Zytiga) are more prone to their PC morphing into Neuroendocrine ?
I read a post today that it’s more common that patients on Abiraterone (Zytiga) are more prone to their Prostate Cancer morphing into Neuroendocrine Carcinoma? Is this true? Any other Medications that are prone to have it Morp into Neuroendocrine Carcinoma ?
I read a post today that it’s more common that patients on Abiraterone (Zytiga) are more prone to their Prostate Cancer morphing into Neuroendocrine Carcinoma? Is this true? Any other Medications that are prone to have it Morp into Neuroendocrine Carcinoma ?
Shorehousejam
in
Advanced Prostate Cancer
11 months ago
Possible Cure
Hi, I was diagnosed initially 2 years ago as Stage 4 with mets to the bones. Low volume. Gleason 8-9, PSA less than 2 from the onset. I had radiation to the prostate only. After 2 years of Lupron/Zytiga, everything has shrunk or disappeared via PSMA PET. Everything has been good,(but with med
Hi, I was diagnosed initially 2 years ago as Stage 4 with mets to the bones. Low volume. Gleason 8-9, PSA less than 2 from the onset. I had radiation to the prostate only. After 2 years of Lupron/Zytiga, everything has shrunk or disappeared via PSMA PET. Everything has been good,(but with med
groth12345
in
Advanced Prostate Cancer
10 months ago
CT and Bone Scan 2 weeks after PSMA PET?
Note:
for reference, my dad lives in BC, Canada. I believe the system here is a bit different than the US - we have a urologist who refers us to the RO when needed. Therefore, there is no relationship between the urologist and RO - the RO is part of the cancer institute, but the urologist is not
Note:
for reference, my dad lives in BC, Canada. I believe the system here is a bit different than the US - we have a urologist who refers us to the RO when needed. Therefore, there is no relationship between the urologist and RO - the RO is part of the cancer institute, but the urologist is not
sixmongoos
in
Advanced Prostate Cancer
9 months ago
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