Clinical Trial Dallas UT Southwestern

[pilot52]

Will begin a Pfizer starting on Monday. I will post more later as it goes. We are adding a drug to Xtandi to treat solid tumors. I have been on and off Xtandi a few times. I am chemo naive. In the past had a very heavy tumor load and received 3 rounds of Lu-177 from Ishita Sen, Fortis health in Delhi. 18 months later 2 more rounds. I currently have 4 small tumors and a PSA of 1.54 and climbing. My physical fitness includes 200 - 300 minutes of high intensity work outs. I feel out standing. Get a little rib pain where the two most active lesions are located. I am posting this because of an interesting statement Dr. Sen made to me. After a second Guardant360 test two years after a complete normal test I have developed the P53 variant . Not good for standard of care as I understand it. However, in 2019 when I presented with a heavy tumor load 24+ lesions and PSMA avid we were not sure how well I would do. I am a low PSA emitter and Gleason 9 all 12 cores tested. The point I want to bring up is that she remarked that now she can see why I responded so well to Lu-177. I will post part of her reply to me. This is only FYI ..you can take it anyway you want. I will not respond to arguments I am only throwing this out.

Dr. Sen "While almost 50% of mCRPC patients demonstrate P53 mutation either in the native tumour or as an acquired defect, it has been advocated as one of the reasons for refractory PCa. Pca harbouring the P53 gene is often unresponsive to Docetaxel as well.

Having said that these defective genes also make the tumour more radiosensitive. Probably the reason why you had such a good response with lu177 psma therapy. "

Keep flying! Blue Skies!

Sky King and Penny ( woof)

[Proflac]

Really interesting.. Thanks for posting and good luck with the trial. Xx

[pilot52 in reply to Proflac]

TY

[Tall_Allen]

Can you get spot radiation to the painful rib metastases?

[pilot52 in reply to Tall_Allen]

Hey Tall, that was my first question, as I have Andy Wang who is vice chair of research and my radiation oncologist Since I had two new lesions in addition to the ribs , I had two lesions which were in remission as the PSMA was decreasing my first thought was wow hit those ribs with SBRT. Same as you are thinking. I have had one round of SBRT in the past and so I was pumped thinking lets hit those and the new one which what pretty hot on my SI joint. He felt like we were chasing an elusive shadow. Now, not to mean if we bring this under control it is not an option. I could have gone to Charleston for the trial but I have such a good team who supported India and we stay on the same page that I chose to go to Dallas. I wanted a trial at City of Hope but it was closed out. Hey the ribs tweak at night occasionally and I row a Peloton and after a long hard row a tiny tweak.....thanks for reaching out.....I never take a med so no big deal....Did not proof ....later gator

[tango65]

What is the name of the drug that will be added to enza?

[pilot52 in reply to tango65]

Simply a number and I will give you the trial later....beer and pizza night

[tango65 in reply to pilot52]

Thanks, enjoy the pizza and the beer. Just the number of the drug will be enough.

[pilot52 in reply to tango65]

STU-2020-0733 Title of Study: A PHASE I DOSE ESCALATION AND EXPANDED COHORT STUDY OF PF-06821497

This is the clinical trial . I did not include my release as it is quite confusing and was produced at the beginning of this trial. As with all trials we have an evolution of results which occur. More importantly when I do do pizza...( that sounds unappetizing ) I have it shipped by Goldbelly...I like Bartolini from Chicago , and had another source last night that was frigging incredible...Guiness Stout in a Black can to go with it...Blue Skies my Brother

[tango65]

Thanks. Best of luck with the treatment

[GP24]

Here is an abstract describing this trial:

ascopubs.org/doi/abs/10.120...

[j-o-h-n]

"This is only FYI ..you can take it anyway you want. I will not respond to arguments I am only throwing this out."

Shit! So now I have to go and argue with the boss again............. Thanks Pal...(woof my doof)...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/22/2023 7:33 PM DST