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Experiences with
Primary ciliary dyskinesia (PCD)
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IS DYSKINESIA PART OF PD?
Hi friends. Kindly help with your replies.I recently saw my Neurologist,and he wanted me to increase my dose of sinemet from 1&1/4 to two tabs 4x daily,but I am kind of reluctant most especially due to dyskinesia. My MD seem unhappy with me and told me that dyskinesia is part of PD,that once you have
Hi friends. Kindly help with your replies.I recently saw my Neurologist,and he wanted me to increase my dose of sinemet from 1&1/4 to two tabs 4x daily,but I am kind of reluctant most especially due to dyskinesia. My MD seem unhappy with me and told me that dyskinesia is part of PD,that once you have
OREOLU
in
Cure Parkinson's
5 years ago
Are These Endo Symptoms?
I'm waiting on a date for a laparoscopy, after suffering with symptoms of endometriosis for years. However I have some symptoms I haven't heard other people talking about! So, I just wondered if anyone suffers like I do? Firstly, the worst of my pain seems to be mid cycle. I have long cycles (around
I'm waiting on a date for a laparoscopy, after suffering with symptoms of endometriosis for years. However I have some symptoms I haven't heard other people talking about! So, I just wondered if anyone suffers like I do? Firstly, the worst of my pain seems to be mid cycle. I have long cycles (around
CalamityJane95
in
Endometriosis UK
5 years ago
Better L-Dopa delivery?
Hello all! I read this about the paradise brand capsules in terms of how to deliver that although bit better: “this product is very effective, but note what they don't tell you, is that in order for the brain to make it into the enzyme that utilizes L-dopa you require an activator like Green Tea or
Hello all! I read this about the paradise brand capsules in terms of how to deliver that although bit better: “this product is very effective, but note what they don't tell you, is that in order for the brain to make it into the enzyme that utilizes L-dopa you require an activator like Green Tea or
MissRita
in
Cure Parkinson's
5 years ago
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WHY IS CARBIDOPA USED IN COMBINATION WITH LEVODOPA IN DRUGS SUCH AS SINEMET?
This is a question that I have heard different answers for in different places on the web, but never was quite sure what the exact reason was, but I have noticed that there is a group who believes that Carbidopa itself can be a problem and would prefer alternatives to Carbidopa while some people use
This is a question that I have heard different answers for in different places on the web, but never was quite sure what the exact reason was, but I have noticed that there is a group who believes that Carbidopa itself can be a problem and would prefer alternatives to Carbidopa while some people use
chartist
in
Cure Parkinson's
5 years ago
Has anyone reduced their dosage of venlafaxine / effexor? I have decreases from 150mg to 75mg. What type of symptoms should I expect?
Hi, has anyone personally experienced or know someone who has reduced their dosage of venlafaxine / Effexor ( SNRIs- serotonin and norepinephrine reuptake inhibitors ). I am experiencing a tremendous amount of brain fog and I am not sure why. I reduced my dosage about 45 days ago. I am also experiencing
Hi, has anyone personally experienced or know someone who has reduced their dosage of venlafaxine / Effexor ( SNRIs- serotonin and norepinephrine reuptake inhibitors ). I am experiencing a tremendous amount of brain fog and I am not sure why. I reduced my dosage about 45 days ago. I am also experiencing
moparkie715
in
PSP Association
5 years ago
Help with Amantadine
Has anyone else experienced severe side effects from taking Amantadine. I was falling on a regular basis and getting hurt. I live in Denver and after seeing 2 different neurologist without any relief I went to the Mayo Clinic in Jacksonville F!. where they are known for successful treatments for
Has anyone else experienced severe side effects from taking Amantadine. I was falling on a regular basis and getting hurt. I live in Denver and after seeing 2 different neurologist without any relief I went to the Mayo Clinic in Jacksonville F!. where they are known for successful treatments for
Donnie1336
in
Cure Parkinson's
5 years ago
Why You Should Be Careful With Niacin and Nicotinamide Riboside
Are you using niacin or nicotinamide riboside? If so, watch this video! These supplements can help you age more gracefully and give you more energy, but they can also hurt your liver, mess with your neurotransmitters and your mood, and even sap your energy. https://youtu.be/P5UMfCW_23w
Are you using niacin or nicotinamide riboside? If so, watch this video! These supplements can help you age more gracefully and give you more energy, but they can also hurt your liver, mess with your neurotransmitters and your mood, and even sap your energy. https://youtu.be/P5UMfCW_23w
Kia17
in
Cure Parkinson's
5 years ago
Why should not we increase L-Dopa bioavailability in the Brain
After watching this video you will find out why you shouldn’t manipulate the L Dopa bioavailability in the brain. https://youtu.be/_eq28PCvfsg You are trying to balance something but you will end up messing with the same thing, in this case the Dopamine.
After watching this video you will find out why you shouldn’t manipulate the L Dopa bioavailability in the brain. https://youtu.be/_eq28PCvfsg You are trying to balance something but you will end up messing with the same thing, in this case the Dopamine.
Kia17
in
Cure Parkinson's
5 years ago
Dyskinesia or Tremor??? I nod my head like saying “Yes” and side to side like saying “No”..............
If I’m in front of people, the nodding starts slow but then increase speed until I can no longer control it, then when I’m by myself it stops. At first I thought it was because of the c/l since I take 4 tablets day, tried lowering doses, but even then I still have the nodding (but I don’t know if I gave
If I’m in front of people, the nodding starts slow but then increase speed until I can no longer control it, then when I’m by myself it stops. At first I thought it was because of the c/l since I take 4 tablets day, tried lowering doses, but even then I still have the nodding (but I don’t know if I gave
Chicafromchitown
in
Cure Parkinson's
5 years ago
Levodopa and CYP3A4, but probably not Grapefruit juice... The next steps
The next step in my research will be to help set up a "Proof of Concept" trial, hopefully with an international team of experts in pharmacology, pharmacokinetics, drug development and Parkinson's disease. This means scientifically answering the following question (or something like it). "Does inhibition
The next step in my research will be to help set up a "Proof of Concept" trial, hopefully with an international team of experts in pharmacology, pharmacokinetics, drug development and Parkinson's disease. This means scientifically answering the following question (or something like it). "Does inhibition
wriga
in
Cure Parkinson's
5 years ago
Cause of dyskinesia? Parkinsons or carbilev? Advice about amantadine?
I am on half 100/25 c/l more or less every 6 hours. I am fine during the day but I have to get up and move during the night or I end up jerking hopelessly for hours. Last night I was up from 12 to 1.30 and again at 4 am. When I told the neuro that I feel cl does nothing for me (my tremor gets worse
I am on half 100/25 c/l more or less every 6 hours. I am fine during the day but I have to get up and move during the night or I end up jerking hopelessly for hours. Last night I was up from 12 to 1.30 and again at 4 am. When I told the neuro that I feel cl does nothing for me (my tremor gets worse
Celtis
in
Cure Parkinson's
5 years ago
Artificial sweetened Cola drinks rapid relief?
Hi, i was dx with PD in 2014, and started out with selegilin and Requip (dopamin agonist), later adding L-DOPA (Madopar/Sinemet) and entakapon. Altogether enabling me to work full time, and I am convinced this would not be possible without such a «cocktail». Still, episodes of fatigue with loss
Hi, i was dx with PD in 2014, and started out with selegilin and Requip (dopamin agonist), later adding L-DOPA (Madopar/Sinemet) and entakapon. Altogether enabling me to work full time, and I am convinced this would not be possible without such a «cocktail». Still, episodes of fatigue with loss
Perno
in
Cure Parkinson's
5 years ago
Sinemet suddenly not working well
Any advice would be welcome. I take 3 100/25 sinemet a day an have been since January. Before that I was taking 2 a day for 6 months. I also take rasagiline 1mg. The sinemet was making a real difference for me for 4 hours at a time 8am. 12 and 4pm until the last 3 weeks where now it only lasts 1 to 2
Any advice would be welcome. I take 3 100/25 sinemet a day an have been since January. Before that I was taking 2 a day for 6 months. I also take rasagiline 1mg. The sinemet was making a real difference for me for 4 hours at a time 8am. 12 and 4pm until the last 3 weeks where now it only lasts 1 to 2
gingerj
in
Cure Parkinson's
5 years ago
Wallowing in the Trough of Carbidopa and Benserazide
I hesitate to even start a thread that is heresy to many, many PD sufferers, many self proclaimed pharmacologists/biochemists on this forum and many of their physicians as well. It is all about a couple of PD drugs that can go very deadly if used inappropriately. Please realize, if you can do so, that
I hesitate to even start a thread that is heresy to many, many PD sufferers, many self proclaimed pharmacologists/biochemists on this forum and many of their physicians as well. It is all about a couple of PD drugs that can go very deadly if used inappropriately. Please realize, if you can do so, that
sharoncrayn
in
Cure Parkinson's
5 years ago
Friday’s Meet
Yesterday I left my house at the crack of dawn , well 7.45 am but that is crack of dawn post PSP . Actually I was up at 6.30 , force of habit over the past few years but I digress ,where was I oh yes leaving home to go to the PSP Carers’ meeting in London . I felt a bit apprehensive about going because
Yesterday I left my house at the crack of dawn , well 7.45 am but that is crack of dawn post PSP . Actually I was up at 6.30 , force of habit over the past few years but I digress ,where was I oh yes leaving home to go to the PSP Carers’ meeting in London . I felt a bit apprehensive about going because
Georgepa
in
PSP Association
5 years ago
Does anyone have any sleeping remedies or meds that work?
I was taking Endep (which gave me a full night's sleep) but my Neurologist changed me from Stalevo (which was giving me Dyskenesia) to Madopar + Xadago. But I had to cease the Endep as he said it could conflict with the Xadago, which is a fairly new drug that is still being trialled. He prescribed Paxam
I was taking Endep (which gave me a full night's sleep) but my Neurologist changed me from Stalevo (which was giving me Dyskenesia) to Madopar + Xadago. But I had to cease the Endep as he said it could conflict with the Xadago, which is a fairly new drug that is still being trialled. He prescribed Paxam
Hidden
in
Cure Parkinson's
5 years ago
Madopar
Hello all My husband has been prescribed Madopar 50 mg which is levodopa and benserazide. He has CBD this is to help jerks. I have not given this to him as the jerks are not too bad. Has anyone had a positive experience with this medication please
Hello all My husband has been prescribed Madopar 50 mg which is levodopa and benserazide. He has CBD this is to help jerks. I have not given this to him as the jerks are not too bad. Has anyone had a positive experience with this medication please
Northstar1
in
PSP Association
5 years ago
More pieces to the puzzle about getting a more stable supply of levodopa to the brain
Here is my latest article about how the CYP3A4 enzyme metabolises levodopa and controls its bio-availability and haf-life. It is based on a 50-day cycle (n=1) during which CYP3A4 was alternatively non-inhibited and inhibited. The results confirm that CYP3A4 powerfully inhibits levodopa and may be more
Here is my latest article about how the CYP3A4 enzyme metabolises levodopa and controls its bio-availability and haf-life. It is based on a 50-day cycle (n=1) during which CYP3A4 was alternatively non-inhibited and inhibited. The results confirm that CYP3A4 powerfully inhibits levodopa and may be more
wriga
in
Cure Parkinson's
5 years ago
Doctors use levodopa responsiveness to diagnose, but a new report today says a specific gut bacteria prevents it from getting to the brain
I often feel I am sometimes unresponsive to levodopa. I wonder if these bacteria come and go. In addition to the most important matter of controlling symptoms, another place this matters is that we could be excluded from clinical trials for being unresponsive to levodopa when it is not because we do
I often feel I am sometimes unresponsive to levodopa. I wonder if these bacteria come and go. In addition to the most important matter of controlling symptoms, another place this matters is that we could be excluded from clinical trials for being unresponsive to levodopa when it is not because we do
MBAnderson
in
Cure Parkinson's
5 years ago
Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson's disease: a meta-analys
S + L combination therapy is superior to L monotherapy for the improvement of clinical symptoms in PD patients. Moreover, the safety profile of S + L combination therapy is comparable with that of L monotherapy. https://www.ncbi.nlm.nih.gov/pubmed/31175606
S + L combination therapy is superior to L monotherapy for the improvement of clinical symptoms in PD patients. Moreover, the safety profile of S + L combination therapy is comparable with that of L monotherapy. https://www.ncbi.nlm.nih.gov/pubmed/31175606
Farooqji
in
Cure Parkinson's
5 years ago
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