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Just 5% of therapies tested in animals end up as as human drugs, new study shows. CLL research has particular challenges due to the TME
There's a long and challenging journey from microscope observations of cancer cells hopefully dying while exposed to candidate therapies, that is, 'in vitro' testing, to successful in vivo human studies, clinical trials and eventual approval. Not only does the therapy need to kill the cancer cells with
There's a long and challenging journey from microscope observations of cancer cells hopefully dying while exposed to candidate therapies, that is, 'in vitro' testing, to successful in vivo human studies, clinical trials and eventual approval. Not only does the therapy need to kill the cancer cells with
AussieNeil
Partner
in
CLL Support
15 days ago
thyroid issues and a fibs???
Does anyone on this site know if there is a link between a fibs and a high TSH blood test? I have been hypothyroid most of my life and have to take synthroid, due to a partial thyroidectomy in my twenties. I am now 69 and have recently developed a fibs. I also might have apnea; am getting a sleep
Does anyone on this site know if there is a link between a fibs and a high TSH blood test? I have been hypothyroid most of my life and have to take synthroid, due to a partial thyroidectomy in my twenties. I am now 69 and have recently developed a fibs. I also might have apnea; am getting a sleep
peachtreepiggy
in
Atrial Fibrillation Support
15 days ago
Please read...
I hope you all take the time to read Ipsen Pharmaceutical's announcements concerning PBC drugs.. Just google ' Ipsen Pharmaceutical announcement' ........ keeping the use of placebos in the clinical trials just wanted valuable time from those who are not responders to other drugs - Urso and OCA.'
I hope you all take the time to read Ipsen Pharmaceutical's announcements concerning PBC drugs.. Just google ' Ipsen Pharmaceutical announcement' ........ keeping the use of placebos in the clinical trials just wanted valuable time from those who are not responders to other drugs - Urso and OCA.'
DonnaBoll
Administrator
in
PBC Foundation
16 days ago
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Update
Hi all. Unfortunately after 3 additional rounds of Carboplatin and Etoposide chemo has failed and the cancer is growing both in Martins Liver and his bones. We have a meeting with his MO this evening. Not sure if there is anything left to try. Have been checking out clinical trials etc but if anyone
Hi all. Unfortunately after 3 additional rounds of Carboplatin and Etoposide chemo has failed and the cancer is growing both in Martins Liver and his bones. We have a meeting with his MO this evening. Not sure if there is anything left to try. Have been checking out clinical trials etc but if anyone
Believeit
in
Advanced Prostate Cancer
17 days ago
CRISPR: not PCa but cold solid tumors related!
I have the feeling that this is the first CRISPR based cancer therapy to reach clinical trial phase…great! I looooove CRISPR! https://www.insideprecisionmedicine.com/topics/oncology/goldeneye-ksq-doses-first-solid-tumor-patient-with-crispr-cas9-etils/
I have the feeling that this is the first CRISPR based cancer therapy to reach clinical trial phase…great! I looooove CRISPR! https://www.insideprecisionmedicine.com/topics/oncology/goldeneye-ksq-doses-first-solid-tumor-patient-with-crispr-cas9-etils/
Maxone73
in
Advanced Prostate Cancer
18 days ago
AZP2006 - Update
My husband has Parkinsons - I am always researching as to what is new and what might be helpful besides using the gold standard - Levodopa/Carbidopa for Parkinsons which incidentally was developed in the 1960's. It's high time that there is new research and new drugs available for Parkinsons patients
My husband has Parkinsons - I am always researching as to what is new and what might be helpful besides using the gold standard - Levodopa/Carbidopa for Parkinsons which incidentally was developed in the 1960's. It's high time that there is new research and new drugs available for Parkinsons patients
Osteopathic
in
Cure Parkinson's
19 days ago
Leukemia-associated macrophages, their role in the CLL Tumor Micro-environment and how they affect progression and therapy response
Understanding how the CLL Tumor Micro-environment (TME) functions is crucial to improving CLL therapy. CLL cells are not as robust as healthy B cells and they rely on their created TME in the nodes and bone marrow for their survival. That's why it's so easy to kill CLL cells with in vitro testing - checking
Understanding how the CLL Tumor Micro-environment (TME) functions is crucial to improving CLL therapy. CLL cells are not as robust as healthy B cells and they rely on their created TME in the nodes and bone marrow for their survival. That's why it's so easy to kill CLL cells with in vitro testing - checking
AussieNeil
Partner
in
CLL Support
22 days ago
Clinical impact of mutated JAK2 allele burden reduction in polycythemia vera and essential thrombocythemia
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
Manouche
in
MPN Voice
22 days ago
Cardioversion - preparation and aftercare - advice please!
Hi everyone, and hope a day of sunshine has raised spirits!I've been placed on a waiting list for cardioversion by my EP which I'm really happy about. I was diagnosed with AF last September or October (got a cat on my knee so can't get up to check the date!) and this rapidly progressed to persistent.
Hi everyone, and hope a day of sunshine has raised spirits!I've been placed on a waiting list for cardioversion by my EP which I'm really happy about. I was diagnosed with AF last September or October (got a cat on my knee so can't get up to check the date!) and this rapidly progressed to persistent.
Rainfern
in
AF Association
1 year ago
What is wrong with these drs?
Still doing great on Sotalol, so thankful for my new EP. I went to a new primary care last week, and we discussed my AF briefly. He said "why aren't you on anticoagulants?" "My EP said I don't need it at my age and with how little I get AF." He then brought it up again a short time later, "you might
Still doing great on Sotalol, so thankful for my new EP. I went to a new primary care last week, and we discussed my AF briefly. He said "why aren't you on anticoagulants?" "My EP said I don't need it at my age and with how little I get AF." He then brought it up again a short time later, "you might
ChasMartin
in
AF Association
1 year ago
Terbium-161 - As a follow-up to Alicia Morgan's comments in the PeterMac GUcast interview posted earlier by marnie46.
I meant to include this article, a 24 Nov 2023 news release on Terbium-161, in a followup reply to Marnie's post of the Dr. Morgan interview by the excellent PeterMac team several days back. [i]
Three big challenges in metastatic prostate cancer | Dr Alicia Morgans
[/i] [i]
https://healthunlocked.com
I meant to include this article, a 24 Nov 2023 news release on Terbium-161, in a followup reply to Marnie's post of the Dr. Morgan interview by the excellent PeterMac team several days back. [i]
Three big challenges in metastatic prostate cancer | Dr Alicia Morgans
[/i] [i]
https://healthunlocked.com
cujoe
in
Fight Prostate Cancer
23 days ago
Important from The PBC Foundation....
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
DonnaBoll
Administrator
in
PBC Foundation
23 days ago
Genetic background strongly influences the impact of carrying the Thr92Ala-DIO2 polymorphism in the male mouse
Are you male? Are you a mouse? Do you carry the Thr92Ala-DIO2 allele? Can you wait for the publication of this paper? Can you wait for the human version of this trial? And do you consider it necessary to wait for the eventual publication of the human trial before considering T3? It is undoubtedly
Are you male? Are you a mouse? Do you carry the Thr92Ala-DIO2 allele? Can you wait for the publication of this paper? Can you wait for the human version of this trial? And do you consider it necessary to wait for the eventual publication of the human trial before considering T3? It is undoubtedly
helvella
Thyroid UK
in
Thyroid UK
24 days ago
Annovis Bio Inc. (NYSE: ANVS) Schedules Investor Webcast
For those of you who might be interested... MALVERN, Pa. June 5, 2024 -- Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease
For those of you who might be interested... MALVERN, Pa. June 5, 2024 -- Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease
Canddy
in
Cure Parkinson's
24 days ago
Phase 1/2 ARV-766 clinical trial
“The purpose of this study is to assess the safety and tolerability (good and bad effects) and how prostate cancer responds to two different doses of the investigational study drug (ARV-766) in combination with Abiraterone in men with metastatic cRPC who have not received prior novel hormonal therapies
“The purpose of this study is to assess the safety and tolerability (good and bad effects) and how prostate cancer responds to two different doses of the investigational study drug (ARV-766) in combination with Abiraterone in men with metastatic cRPC who have not received prior novel hormonal therapies
Woodman33
in
Advanced Prostate Cancer
25 days ago
FDA Greenlights Phase 2/3 Trial of KPG-121/Abiraterone in mCRPC
A clinical trial to evaluate the combination of a new drug called KPG-121 with abiraterone acetate (Zytiga) for treating metastatic castration-resistant prostate cancer (mCRPC) as a first-line therapy has been approved by the FDA. KPG-121 is an investigational drug that targets specific proteins involved
A clinical trial to evaluate the combination of a new drug called KPG-121 with abiraterone acetate (Zytiga) for treating metastatic castration-resistant prostate cancer (mCRPC) as a first-line therapy has been approved by the FDA. KPG-121 is an investigational drug that targets specific proteins involved
God_Loves_Me
in
Advanced Prostate Cancer
25 days ago
Denmeade on identifying patients who may benefit from BAT
Dr. Denmeade concluded his presentation with the following key takeaways: The presence of AR alterations in ctDNA may identify patients who may or may not benefit from BAT In this study patients with no AR alterations treated with BAT exhibit significantly shorter PFS and OS compared to those treated
Dr. Denmeade concluded his presentation with the following key takeaways: The presence of AR alterations in ctDNA may identify patients who may or may not benefit from BAT In this study patients with no AR alterations treated with BAT exhibit significantly shorter PFS and OS compared to those treated
cigafred
in
Fight Prostate Cancer
25 days ago
Fifth Ablation Done
The EP at Lovelace Heart in Albuquerque, Dr. Bestswros, (aka TopGun Maverick) zapped everything in sight after trying the usual suspects. His notes: “Pulmonary vein isolation was performed at the level of the antrum. Successful PVI of LSVP. PVI x 3 confirmed. Rotor ablation for atrial fibrillation.
The EP at Lovelace Heart in Albuquerque, Dr. Bestswros, (aka TopGun Maverick) zapped everything in sight after trying the usual suspects. His notes: “Pulmonary vein isolation was performed at the level of the antrum. Successful PVI of LSVP. PVI x 3 confirmed. Rotor ablation for atrial fibrillation.
DKBX
in
AF Association
1 year ago
Afib medications
HiI've been reading all the posts for 5 years but never asked anything until today. I was diagnosed with lone perm afib 6 years ago, i was 64. I was totally asymtomatic but advised to take a anticoagulant and beta blocker. I tried a couple of anticoags before settling on eliquis. I could not tolerate
HiI've been reading all the posts for 5 years but never asked anything until today. I was diagnosed with lone perm afib 6 years ago, i was 64. I was totally asymtomatic but advised to take a anticoagulant and beta blocker. I tried a couple of anticoags before settling on eliquis. I could not tolerate
fodgreen
in
AF Association
1 year ago
Totally confused
I had a partial thyroidectomy about 2010. My thyroid levels were fine for several years but then started dropping into hypothyroidism range. I was put on Levothyroxine at 50mg and was ok for few years. Tested Jan 2023 was ok. Tested early Feb 2024 and was hyper not hypo so my gp reduced the levothyroxine
I had a partial thyroidectomy about 2010. My thyroid levels were fine for several years but then started dropping into hypothyroidism range. I was put on Levothyroxine at 50mg and was ok for few years. Tested Jan 2023 was ok. Tested early Feb 2024 and was hyper not hypo so my gp reduced the levothyroxine
Battlecat
in
Thyroid UK
30 days ago
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