Hello all, my latest pet/ct scan indicates my PC is no longer castrate resistant as there is new disease growth in my lungs. Largest lesion is 2.5 centimeters. I'm no longer taking xtandi, so it can be "washed out" of my system prior to new treatment, however I'm still getting quarterly lupron shots. My question then is do I go with what my doc recommends (either Taxotere chemo or a new phase 1b clinical trial with combo drugs JNJ-78278343 and cetrelimab)? He says there are other pills I can choose to take instead, such as Zytiga with a parp inhibitor, Opdivo or Nirapared, but still thinks the chemo or clinical trial are better choices for me.
I'm getting a second opinion, but any insights you guys might have would be helpful.
Thanks,
Joe Mason
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brokenyoyo
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It definitely sounds like you are now moving on to cytotoxic drugs that kill prostate cancer rather than the ADT drugs that suppress cancer cells. You might want to check out Lutetium (Pluvicto). It doesn't work for everyone but for some men it is miraculous. Good luck!
it is unclear what he meant. i read it several times but think he is suggesting that no progression suggests that CR is no longer the case. a bit confusing to me and to you ?
Yes the CR reference was an error on my part. Sigh, cognitive decline on my part, the PC is no longer castration sensitive. I appreciate your information guys. It is good to talk to people who use normal words.
Ingress: your reply is helpful in that I've been afraid to try Taxotere because of the chemo stigma associated, not knowing how I would tolerate it. With that said, I'm a guinea pig if I go with the clinical trial...
Taxotere was a drag at some points in the cycle, but not brutal by any stretch. I also had an image in my mind of "chemo" patient having green skin, emaciated, and throwing up every time they tried to speak, but it turned out that this wasn't based in reality. I was still squatting 275 for reps on Taxotere, going grocery shopping near the end of each 3-week cycle when my neutrophils recovered, etc. It felt like having a low-grade fever for the first 10 days after the shot, with just a bit of lingering fatigue after that.
You'll have to mask up to leave the house so you don't catch a cold and die, but hey this is something we're still used to at this point so it's no big deal. If it could save your life, don't pass it up - the clinical trial is a roll of the dice (especially if you get the placebo arm), while Taxotere is tested and proven to be effective against PCa.
I shoud add, the fatigue was manageable with strategic timing of caffeine (did a half-serving of pre-workout before those weight training sessions), and I also used modafinil on certain days when I wanted to be sharp (I did phone work from home during chemo). The scientific research on moda concluded that it didn't help chemo patients with fatigue, but I beg to differ as it definitely worked in my case.
The standard for your stage is triplet therapy. That would be a course of taxotere and at least 2 years of Lipton and a receptor blocker such as Nubeqa, abiraterone.
Hi Joe, We have similar metastatic CRPC in our lungs, although my disease is more advanced & I’m a little older at 81. So far I’ve had 1/2 of one of my lungs removed & 3 biopsies so far & still on ADT. My PSA is under 0.1 & have had lots of scans. A few months ago I completed 7 infusions of Docetaxel & I am about to have my 2nd infusion of Pluvicto. The Docetaxel had only a limited impact on my cancer and although it sounded a little scary, it was much less impactful on my quality of life than I anticipated. Since we have a rather unique location of our cancer, it could be valuable for us talk further. Best to you.
And no mention above on "Spot Treating" those lung mets with radiation? Especially if there's just a few... "Whack-a-Mole" therapy for this may also be effective!
Of course, the standard disclaimer that we are all different as is our cancers applies. It all just depends on the particular diagnosis, and of course, prognosis, in order to make a personal decision on what's "Best" for you.
Pluvicto could be a good option, have you tried or looked into ivermectin And cbd oil, Joe Tippens protocol def worth looking at. I followed it after finding a pub med article on ivermectin possibly being repurposed as an anti cancer ♋️ drug n am having tremendous results from it… here’s the article from pub med
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