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Treatment Resistant Depression
I have had depression since my 20’s and likely in teens. I’m now 56 and my meds are no longer working like they once did. I’m going to be meeting with a clinic about other options ie: ECT etc. I’m very scared and anxious as this feels next level to me in my illness. Have you tried ECT and/or Esketamine
I have had depression since my 20’s and likely in teens. I’m now 56 and my meds are no longer working like they once did. I’m going to be meeting with a clinic about other options ie: ECT etc. I’m very scared and anxious as this feels next level to me in my illness. Have you tried ECT and/or Esketamine
Doubledog
in
Major Depressive Disorder (MDD) Support
7 months ago
Vitamin and mineral deficiencies/Thyroid dysfunction.. Chicken or Egg?
Before I spend my hard earned money on going to a private ENDO because the NHS is failing me I wanted to ask what you all thought about the problem of iron deficiency and vitamin D deficiency and how this relates to underactive thyroid . I read a lot here about how these vitamins should be optimal for
Before I spend my hard earned money on going to a private ENDO because the NHS is failing me I wanted to ask what you all thought about the problem of iron deficiency and vitamin D deficiency and how this relates to underactive thyroid . I read a lot here about how these vitamins should be optimal for
doingitfordad
in
Thyroid UK
10 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
janebob99
in
Prostate Cancer Network
5 months ago
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Low Testosterone reduces Survival by a huge amount.
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
This plot compares prostate cancer specific mortality probability versus time for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable intermediate risk who underwent
janebob99
in
Prostate Cancer Network
5 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
5 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
5 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
5 months ago
help with bloods.
I have been on HRT for 5 years. I'm currently on 300mg Utrogestan (100mg to 200mg 17/10 then 200mg 25 on 3 days off then up to 300mg on 11/2/24 25 days on 3 days off) and 100 evorel patch plus 1 pump of tostran gel twice a week. I have been having bleeds since June 23 (had an internal scan and biopsy
I have been on HRT for 5 years. I'm currently on 300mg Utrogestan (100mg to 200mg 17/10 then 200mg 25 on 3 days off then up to 300mg on 11/2/24 25 days on 3 days off) and 100 evorel patch plus 1 pump of tostran gel twice a week. I have been having bleeds since June 23 (had an internal scan and biopsy
WendyW1964
in
Menopause and Perimenopause Support
5 months ago
post menopause bleeding
Hi all, I’m a 64 year old woman whose periods stopped when I was 50, I chose HRT after a few years of non stop daytime sweats, zero concentration and bursting into tears at the drop of a hat 🙈 I stopped the HRT back in 2020 but had to start it again last year as the sweats returned with a vengeance
Hi all, I’m a 64 year old woman whose periods stopped when I was 50, I chose HRT after a few years of non stop daytime sweats, zero concentration and bursting into tears at the drop of a hat 🙈 I stopped the HRT back in 2020 but had to start it again last year as the sweats returned with a vengeance
NanaFifi
in
Women's Health
5 months ago
women of a certain age
ok so it may be time to accept the fact that it may not be just my thyroid causing my issues.?so I’ve read quite a lot about her and think as I didn’t have a good run with levothyroxine I don’t think combining hrt tables as well is the way to go so after reading lots I’m thinking get with a progesterone
ok so it may be time to accept the fact that it may not be just my thyroid causing my issues.?so I’ve read quite a lot about her and think as I didn’t have a good run with levothyroxine I don’t think combining hrt tables as well is the way to go so after reading lots I’m thinking get with a progesterone
Bobby25
in
Thyroid UK
5 months ago
Just some new Information about AI
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
chefjlu
in
Advanced Prostate Cancer
5 months ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
5 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
5 months ago
Another brother passes
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
gsun
in
Advanced Prostate Cancer
5 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
5 months ago
PSA-Nadir vs Testosterone-Nadir comparing Non-CRPC to CRPX men
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA-Nadir vs Testosterone-Nadir
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Prostate Cancer Network
5 months ago
Joint pain
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
Hi I have a history of back pain due to bulges bit more recently joint pain in lower back. The consultant has said some degeneration found but everyone has that. We are now looking at more spinal injections and further treatment.I am in perimenopause and have been on hrt for 2 years. Everol Patches and
AMS_1
in
Menopause and Perimenopause Support
5 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
5 months ago
She doesn’t act that way with me…
I’ve known since my daughter was 2 years old that something was going on, but everyone around me tries to explain it away. It seems like to them having ADHD and sensory processing disorder is the kiss of death and all is lost for her. Why do I have to over explain her symptoms and diagnoses? If I say
I’ve known since my daughter was 2 years old that something was going on, but everyone around me tries to explain it away. It seems like to them having ADHD and sensory processing disorder is the kiss of death and all is lost for her. Why do I have to over explain her symptoms and diagnoses? If I say
yum_yum
in
CHADD's ADHD Parents Together
10 months ago
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