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FDA approved Inavolisib for PIK3 mutation
I am back on here and I wanted to share that my blood biopsy last month showed a PIK3 mutation. Then, since I am a reader, I found out that Inavolisib has just been approved to be taken with ibrance and fulvestrant I currently take ibrance and letrozole. It seems the Inavolisib has less side effects
I am back on here and I wanted to share that my blood biopsy last month showed a PIK3 mutation. Then, since I am a reader, I found out that Inavolisib has just been approved to be taken with ibrance and fulvestrant I currently take ibrance and letrozole. It seems the Inavolisib has less side effects
Godbeforme
in
SHARE Metastatic Breast Cancer
2 months ago
estrogen cream
Hi! I’m wondering if any of you ladies have tried estrogen vaginal cream? My oncologist said it’s safe at the percent (I think .01? 1?) prescribed for menopausal women … apparently a study tenderly concluded that women with breast cancer are safe to use this medication to help with the symptoms of lack
Hi! I’m wondering if any of you ladies have tried estrogen vaginal cream? My oncologist said it’s safe at the percent (I think .01? 1?) prescribed for menopausal women … apparently a study tenderly concluded that women with breast cancer are safe to use this medication to help with the symptoms of lack
TwithBC
in
SHARE Metastatic Breast Cancer
2 months ago
sensitive post- cyclogest question
Hello, I’ve recently had a BFP for the first time post a round of letrozole where I initially hadn’t ovulated when I was due to but then seemed to ovulate on d29. Just wondering whether anyone has used cyclogest prophylactically to support pregnancy? Thank you in advance x
Hello, I’ve recently had a BFP for the first time post a round of letrozole where I initially hadn’t ovulated when I was due to but then seemed to ovulate on d29. Just wondering whether anyone has used cyclogest prophylactically to support pregnancy? Thank you in advance x
tarka123
in
Fertility Network UK
2 months ago
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Evening Primrose update
Hi. I was diagnosed with stage 1 breast cancer a year ago. I had surgery and radiotherapy and was put on Letrozole. I have had a few problems with the Letrozole, which saw me come off it for a while. I was put back on it and the Oncology Nurse told me to take Evening Primrose oil. it’s been 3 months
Hi. I was diagnosed with stage 1 breast cancer a year ago. I had surgery and radiotherapy and was put on Letrozole. I have had a few problems with the Letrozole, which saw me come off it for a while. I was put back on it and the Oncology Nurse told me to take Evening Primrose oil. it’s been 3 months
Tabbycat64
in
My Breast Cancer Community
2 months ago
Ovulation induction: feeling emotionally drained
I’ve started my first round of ovulation induction for PCOS with Letrozole 2.5mg. Had my day 10 scan yesterday. Follicles very small and no dominant follicle. Been TTC for 18 months (which I know isn’t that long compared to others), have put so much into this process - I have lost so much weight to
I’ve started my first round of ovulation induction for PCOS with Letrozole 2.5mg. Had my day 10 scan yesterday. Follicles very small and no dominant follicle. Been TTC for 18 months (which I know isn’t that long compared to others), have put so much into this process - I have lost so much weight to
Melsunshine
in
Fertility Network UK
2 months ago
Long Term Ibrance/letrozole Side Effects?
Hello lovelies. I'm 7 1/2 years into my first treatment protocol. Currently on 75mg Ibrance (three weeks on, two off) and letrozole daily with Xgeva shots quarterly. My neutrophils haven't been great - never over .9 and occasionally .6 or .7 but my doc doesn't think that's too important. He doesn't
Hello lovelies. I'm 7 1/2 years into my first treatment protocol. Currently on 75mg Ibrance (three weeks on, two off) and letrozole daily with Xgeva shots quarterly. My neutrophils haven't been great - never over .9 and occasionally .6 or .7 but my doc doesn't think that's too important. He doesn't
Aquadog
in
SHARE Metastatic Breast Cancer
2 months ago
Scan showed what was thought to be bone Mets but were fractures
Hi I'm 3 years since Mets diagnosed. Started with Mets to lungs and several lymphnodes after 7 months of injections I was put on ibrance and letrozole for a year when I started to have bone pain and a lot of ht flashes my Dr switched me from letrozole to emestane . My scans now show NED on lungs and
Hi I'm 3 years since Mets diagnosed. Started with Mets to lungs and several lymphnodes after 7 months of injections I was put on ibrance and letrozole for a year when I started to have bone pain and a lot of ht flashes my Dr switched me from letrozole to emestane . My scans now show NED on lungs and
DMC21268
in
SHARE Metastatic Breast Cancer
2 months ago
New Primary cancer
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
monkeygirl62
in
The Roy Castle Lung Cancer Foundation
2 months ago
New Primary cancer
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
I have stage 4 metastatic breast cancer ER+ and her2 negative and been on Ibrance and letrozole for since December 2023 though I was diagnosed August 2023. Long story that I mentioned in a previous post. I had a recent biopsy of my upper left lung since I have lung mets. The last biopsy I had said it
monkeygirl62
in
SHARE Metastatic Breast Cancer
2 months ago
MBC and diet
Hi everyone I was first diagnosed with BC in 2000. I had a recurrence (2nd primary) 17 years later. 6 years later I was diagnosed with MBC. I had a small tumor present in my dermis at the masectomy scar sight. They followed with surgery (a lumpectomy to the reconstructed breast and targeted radiation
Hi everyone I was first diagnosed with BC in 2000. I had a recurrence (2nd primary) 17 years later. 6 years later I was diagnosed with MBC. I had a small tumor present in my dermis at the masectomy scar sight. They followed with surgery (a lumpectomy to the reconstructed breast and targeted radiation
CalGal56
in
SHARE Metastatic Breast Cancer
3 months ago
change of therapy
Rarely post, but try to read as often as I can. Hope to get the advice based on your experience. Based on my scans it looks that I have progression. New bone mets. TM are trending higher, but not significant. No mutations. I’m in US. I’m on palbo+letrozole for almost 4 years, but of course not
Rarely post, but try to read as often as I can. Hope to get the advice based on your experience. Based on my scans it looks that I have progression. New bone mets. TM are trending higher, but not significant. No mutations. I’m in US. I’m on palbo+letrozole for almost 4 years, but of course not
Tolife_18
in
SHARE Metastatic Breast Cancer
3 months ago
metastic Breast cancer in chest
Hi I’m pretty new to this site, but love reading the positive posts that give me so much confidence! I’ve had breast cancer three times, the first time I was 37 in 1998 the second 54 2016 and again this year diagnosed under my reconstruction and inoperable! March 2024! I’m on Ibrance and Letrozole since
Hi I’m pretty new to this site, but love reading the positive posts that give me so much confidence! I’ve had breast cancer three times, the first time I was 37 in 1998 the second 54 2016 and again this year diagnosed under my reconstruction and inoperable! March 2024! I’m on Ibrance and Letrozole since
Teddypeppalola
in
SHARE Metastatic Breast Cancer
3 months ago
Anyone had an increase in bone/joint pain after being on Ibrance and Letrozole for a few years?
I was diagnosed Metastatic BC with a lot of bone mets back in June 2022. The Letrozole and Ibrance eliminated the visible bone mets and pain was better. Last scans still show no progression and those were just a month ago or so. The last few weeks I've had terrible pain in my knees, left shin, and
I was diagnosed Metastatic BC with a lot of bone mets back in June 2022. The Letrozole and Ibrance eliminated the visible bone mets and pain was better. Last scans still show no progression and those were just a month ago or so. The last few weeks I've had terrible pain in my knees, left shin, and
lovnmycat
in
SHARE Metastatic Breast Cancer
3 months ago
late ovulation low progesterone
I’ve just done my first round of OI on letrozole for PCOS 2.5mg OD. Was scanned once and no dominant follicles. Told to keep having sex and on day 18 tested with Mira machine. Had big LH surge and both oestrogen and progesterone were higher than previously. Did d21 progesterone blood test today (too
I’ve just done my first round of OI on letrozole for PCOS 2.5mg OD. Was scanned once and no dominant follicles. Told to keep having sex and on day 18 tested with Mira machine. Had big LH surge and both oestrogen and progesterone were higher than previously. Did d21 progesterone blood test today (too
tarka123
in
Fertility Network UK
3 months ago
palbociclib and letrozole
hi, taking palbo and letrozole for last 6 months and few days back gone for pet scan and scan response was good , many places were reduced and not much metabolic activity. So same medicines prescribed, but now suddenly in both legs nerves are paining like shooting pain heavily, will palbociclib or
hi, taking palbo and letrozole for last 6 months and few days back gone for pet scan and scan response was good , many places were reduced and not much metabolic activity. So same medicines prescribed, but now suddenly in both legs nerves are paining like shooting pain heavily, will palbociclib or
Wickey20
in
SHARE Metastatic Breast Cancer
3 months ago
Good news
I haven't written for a while , just getting on with life! But last week's news is worth reporting.The mammary lymph node they had been monitoring is now too small to report measurements. It was 9 mm last time and has further reduced. My cancer markers are better than two and a half years ago. 15-3 is
I haven't written for a while , just getting on with life! But last week's news is worth reporting.The mammary lymph node they had been monitoring is now too small to report measurements. It was 9 mm last time and has further reduced. My cancer markers are better than two and a half years ago. 15-3 is
Beryl71
in
SHARE Metastatic Breast Cancer
3 months ago
Sense of smell
I have been on Ibrance and Letrozole for almost 3 years and lately I have noticed that my sense of smell has diminished. Do any of you have the same issue?
I have been on Ibrance and Letrozole for almost 3 years and lately I have noticed that my sense of smell has diminished. Do any of you have the same issue?
FloridaNYgirl
in
SHARE Metastatic Breast Cancer
3 months ago
letrozole- no dominant follicle.
hello, I’ve just had my first round of letrozole on 2.5mg OD as I was told I have a high amh (67). Also have lean PCOS. I had a scan yesterday on day 12 and no dominant follicle. Largest one they could see was 10.2mm. Have been told to have sex and not do ovulation sticks because of it causing stress
hello, I’ve just had my first round of letrozole on 2.5mg OD as I was told I have a high amh (67). Also have lean PCOS. I had a scan yesterday on day 12 and no dominant follicle. Largest one they could see was 10.2mm. Have been told to have sex and not do ovulation sticks because of it causing stress
tarka123
in
Fertility Network UK
3 months ago
treatment path after Ibrance U.K.
I am under GSTT in London and on Ibrance and Letrozole currently. I wanted to see with ER and PR positive and Her- what treatment paths had been offered to the community after Ibrance. Xx
I am under GSTT in London and on Ibrance and Letrozole currently. I wanted to see with ER and PR positive and Her- what treatment paths had been offered to the community after Ibrance. Xx
TE53_67
in
SHARE Metastatic Breast Cancer
3 months ago
2nd pBAT cycle results: AR upregulation? Double strand breaks? Darolutamide?
Started 2nd pBAT cycle on 4-22-24 with a PSA of 0.62 measured 2 days earlier. All 6 injections were 50 mg eod of T propionate with .625 mg letrozole every 5th day as an aromatase inhibitor. The hiT cycle was cut short by 2 injections because of a plan to SBRT treat a pelvic lymph node chain that lit
Started 2nd pBAT cycle on 4-22-24 with a PSA of 0.62 measured 2 days earlier. All 6 injections were 50 mg eod of T propionate with .625 mg letrozole every 5th day as an aromatase inhibitor. The hiT cycle was cut short by 2 injections because of a plan to SBRT treat a pelvic lymph node chain that lit
Ichthus316
in
Fight Prostate Cancer
3 months ago
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