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Critical Molecular Pathways in CLL Therapy
This is an overview of where we are in CLL treatment and where the research may be most needed at this point in time. Lengthy, with good illus. and delineates targets of current treatments. https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0001-1 Sorry, if this is a duplicate. Conclusion
This is an overview of where we are in CLL treatment and where the research may be most needed at this point in time. Lengthy, with good illus. and delineates targets of current treatments. https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0001-1 Sorry, if this is a duplicate. Conclusion
cllady01
Volunteer
in
CLL Support
5 years ago
One Day at a Time
Hi CLL People, It's been a while since I posted (4 years while to be more precise) and in that time I've been doing exactly as above - taking it 1 day at a time. I have little to report - my bloods have remained pretty constant and my hospital doctor (I have no Consultant) said at our last meeting that
Hi CLL People, It's been a while since I posted (4 years while to be more precise) and in that time I've been doing exactly as above - taking it 1 day at a time. I have little to report - my bloods have remained pretty constant and my hospital doctor (I have no Consultant) said at our last meeting that
mister_Ian_NE
in
CLL Support
5 years ago
“CLL & Heartburn” ??
Weird question but ... the original way I was diagnosed with CLL was because I was having some very strange “heart burn” type of symptoms. And my doctor did a range of test - thyroid, barium swallow & a CBC - everything came back ok except a small amount of acid reflux in the barium swallow & my WCC
Weird question but ... the original way I was diagnosed with CLL was because I was having some very strange “heart burn” type of symptoms. And my doctor did a range of test - thyroid, barium swallow & a CBC - everything came back ok except a small amount of acid reflux in the barium swallow & my WCC
Meamiaam10
in
CLL Support
5 years ago
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Parietal cell antibody test
I know I'm repeating myself but want to be clear. Is it correct that if you test negative for this it's reliable? I've not had the intrinsic factor test. I'm asking as I'm getting the vibe as one year in now the surgery want to decrease my B12 injections. B12 was put on my latest blood form after
I know I'm repeating myself but want to be clear. Is it correct that if you test negative for this it's reliable? I've not had the intrinsic factor test. I'm asking as I'm getting the vibe as one year in now the surgery want to decrease my B12 injections. B12 was put on my latest blood form after
Nackapan
in
Pernicious Anaemia Society
5 years ago
Blood work with a possible change in doctor's
I don't post on here very often so here goes. I started a new GP and Oncologist/Hematologist this year. Prior doctor allowed phlebotomy when HCT was at 44.6. My last phlebotomy was done in January and the one before that was in October. Before that I was getting them on the average of every 6 to 8
I don't post on here very often so here goes. I started a new GP and Oncologist/Hematologist this year. Prior doctor allowed phlebotomy when HCT was at 44.6. My last phlebotomy was done in January and the one before that was in October. Before that I was getting them on the average of every 6 to 8
Alex9621
in
MPN Voice
5 years ago
Test result meaning
Just a question on of my results. The last two land shows a lot of things out of whack. But one is anion gap with a reading of 2 and LL which is critical (panic). I was diagnosed with CLL in February 2018. Started Gayza in September thru December. Was about 16 treatments. Labs did not improve. I have
Just a question on of my results. The last two land shows a lot of things out of whack. But one is anion gap with a reading of 2 and LL which is critical (panic). I was diagnosed with CLL in February 2018. Started Gayza in September thru December. Was about 16 treatments. Labs did not improve. I have
Mamawof25
in
CLL Support
5 years ago
Help with anemia
I have Myelofibrosis with hemolytic anemia. Haven’t started Jakafi. Spleen is starting to enlarge. Any ideas of how to control the anemia while taking Jakafi?
I have Myelofibrosis with hemolytic anemia. Haven’t started Jakafi. Spleen is starting to enlarge. Any ideas of how to control the anemia while taking Jakafi?
Jerrymohler
in
MPN Voice
5 years ago
Low Dose Thalidomide
My haemo has floated the idea of low dose thalidomide in combination with prednisone as a potential treatment for my advanced myelofibrosis. I have read a couple of articles on the net which suggest quite a good response in reducing anemia and increasing platelets. Has anyone had experience with this
My haemo has floated the idea of low dose thalidomide in combination with prednisone as a potential treatment for my advanced myelofibrosis. I have read a couple of articles on the net which suggest quite a good response in reducing anemia and increasing platelets. Has anyone had experience with this
47Robert
in
MPN Voice
5 years ago
A Conversation with Dr Tam about Zanubrutinib: A Novel BTK Inhibitor
How does zanubrutinib differ from ibrutinib in pharmacokinetics and target occupancy? Zanubrutinib has a more-specific target binding profile than ibrutinib. It binds to BTK at least as potently as ibrutinib. Zanubrutinib has fewer off-target effects on related enzymes, including the epidermal growth
How does zanubrutinib differ from ibrutinib in pharmacokinetics and target occupancy? Zanubrutinib has a more-specific target binding profile than ibrutinib. It binds to BTK at least as potently as ibrutinib. Zanubrutinib has fewer off-target effects on related enzymes, including the epidermal growth
Jm954
Administrator
in
CLL Support
5 years ago
Adding Venetoclax to Obinutuzumab Prolongs Progression-Free Survival in Previously Untreated CLL
[i]Dated 1st September 2019[/i] In a phase III trial of patients with previously untreated CLL a
nd co-existing comorbidities, a fixed-duration regimen
of obinutuzumab plus venetoclax reduced the risk of disease progression and death by 65%, compared with obinutuzumab plus chlorambucil. The findings
[i]Dated 1st September 2019[/i] In a phase III trial of patients with previously untreated CLL a
nd co-existing comorbidities, a fixed-duration regimen
of obinutuzumab plus venetoclax reduced the risk of disease progression and death by 65%, compared with obinutuzumab plus chlorambucil. The findings
Jm954
Administrator
in
CLL Support
5 years ago
Using nanopore sequencing to look at the diagnostic CLL genome.
This is a bit sciencie but might be of interest to some and looks promising technology, allowing several things to be tested for at the same time. [i]Nanopore sequencing is a third generation approach used in the sequencing of biopolymers in the form of DNA or RNA. Using nanopore sequencing, a single
This is a bit sciencie but might be of interest to some and looks promising technology, allowing several things to be tested for at the same time. [i]Nanopore sequencing is a third generation approach used in the sequencing of biopolymers in the form of DNA or RNA. Using nanopore sequencing, a single
Jm954
Administrator
in
CLL Support
5 years ago
What are the-major-findings-of-the-united-kingdom-prospective-Diabetes-study-ukpds??
UKPDS has been conducting studies on Diabetes since 1977 and during last 42 years they have generated 93 original research papers based upon their trial studies on large number of Diabetes. It is a Bible on diabetes .. giving below few links.....the first link gives the brief summary ... and the second
UKPDS has been conducting studies on Diabetes since 1977 and during last 42 years they have generated 93 original research papers based upon their trial studies on large number of Diabetes. It is a Bible on diabetes .. giving below few links.....the first link gives the brief summary ... and the second
namaha
Administrator
in
Diabetes India
5 years ago
Oncoplex Cancer Gene Panel test
I just got the results of 2 new tests back. One is called an Oncoplex Cancer Gene Panel and the results said : “The sample tested is positive for copy loss of portions of chromosome 5 (includes CD74 and RPS14) and a low level variant in ASLX1 “ I trie to look this up, but was confused by the article
I just got the results of 2 new tests back. One is called an Oncoplex Cancer Gene Panel and the results said : “The sample tested is positive for copy loss of portions of chromosome 5 (includes CD74 and RPS14) and a low level variant in ASLX1 “ I trie to look this up, but was confused by the article
t2aa
in
CLL Support
5 years ago
Clinical trial
Hi everyone. I have myelofibrosis. I am on ruxolitinib at the moment but my platelets keeping dropping. My oncologist put me forward for a clinical trial I went to London talked the very nice Dr. He gave me 2 literature books to read regarding the trial. I really don't know what to do. I'm thinking
Hi everyone. I have myelofibrosis. I am on ruxolitinib at the moment but my platelets keeping dropping. My oncologist put me forward for a clinical trial I went to London talked the very nice Dr. He gave me 2 literature books to read regarding the trial. I really don't know what to do. I'm thinking
Ven61
in
MPN Voice
5 years ago
Does anybody else have Polycythaemia Vera with CAL R and TET2 mutations? My doctors seem to be very confused..
Hey everyone, My name is Erik I’m new here and if anybody has any info they could share with me about this, as I was just diagnosed in December 2018, but haven’t been feeling good for a very long time I would appreciate it!Thank you in advance.
Hey everyone, My name is Erik I’m new here and if anybody has any info they could share with me about this, as I was just diagnosed in December 2018, but haven’t been feeling good for a very long time I would appreciate it!Thank you in advance.
Emurr
in
MPN Voice
5 years ago
Hcl
Recently diagnosed with dle have a consultants appt in 3 weeks to hopefully start hcl. I'm assuming I'll just be given a prescription or do I get a choice of which hcl I'd prefer?? I've had the eye test plus blood /urine tests Thanks in advance for any advise I'm feeling like a little fish in a big
Recently diagnosed with dle have a consultants appt in 3 weeks to hopefully start hcl. I'm assuming I'll just be given a prescription or do I get a choice of which hcl I'd prefer?? I've had the eye test plus blood /urine tests Thanks in advance for any advise I'm feeling like a little fish in a big
Gemllo
in
LUPUS UK
5 years ago
Bone marrow test ?
Hi everybody My wife was diagnosed with CLL five years ago , she’s 13q delation mutated and started Imbruvica in January with excellent results since her numbers are almost back to normal. Her oncologist is in France and since diagnosis, she had two complete scans the first year ,two FISH test in all
Hi everybody My wife was diagnosed with CLL five years ago , she’s 13q delation mutated and started Imbruvica in January with excellent results since her numbers are almost back to normal. Her oncologist is in France and since diagnosis, she had two complete scans the first year ,two FISH test in all
Sergi
in
CLL Support
5 years ago
Today’s WSJ essay on the abject failure of medical science’s progress in dealing with this family of diseases and what must change.
An apparent extension of a highly recommended book that I had read some 8 plus years ago,,,”The Emperor of All Maladies”,,,Now a Ken Burns PBS documentary. The thrust of both books being that intensive treatment of the vast majority of cancers has for many years(4,000 in the case of “The Emperor of
An apparent extension of a highly recommended book that I had read some 8 plus years ago,,,”The Emperor of All Maladies”,,,Now a Ken Burns PBS documentary. The thrust of both books being that intensive treatment of the vast majority of cancers has for many years(4,000 in the case of “The Emperor of
Sxrxrnr1
in
Advanced Prostate Cancer
5 years ago
Potential Early Drivers of Disease in Treatment-Naive CLL Identified
[i]This study reinforces others regarding mutations that predict a short time to first treatment. I think those of us that are 11qdel are aware of the association of 11qdel with mutated ATM and unmutated IGHV status.[/i] By determining the relationship between a set of somatic mutations and established
[i]This study reinforces others regarding mutations that predict a short time to first treatment. I think those of us that are 11qdel are aware of the association of 11qdel with mutated ATM and unmutated IGHV status.[/i] By determining the relationship between a set of somatic mutations and established
Jm954
Administrator
in
CLL Support
5 years ago
Use of MRD Status Following Obinutuzumab/Ibrutinib to Guide Subsequent Intensification of Therapy in CLL
August 6, 2019 In this 2-part, single-arm, open-label, multicenter trial (Clinical Trials.gov Identifier: NCT02666898), medically fit, adult patients with treatment-naive CLL not characterized by a 17p deletion or a mutation in TP53 received 9 months of chemotherapy-free induction therapy with the combination
August 6, 2019 In this 2-part, single-arm, open-label, multicenter trial (Clinical Trials.gov Identifier: NCT02666898), medically fit, adult patients with treatment-naive CLL not characterized by a 17p deletion or a mutation in TP53 received 9 months of chemotherapy-free induction therapy with the combination
Jm954
Administrator
in
CLL Support
5 years ago
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