Oncoplex Cancer Gene Panel test

[t2aa]

I just got the results of 2 new tests back. One is called an Oncoplex Cancer Gene Panel and the results said : “The sample tested is positive for copy loss of portions of chromosome 5

(includes CD74 and RPS14) and a low level variant in ASLX1 “

I trie to look this up, but was confused by the article I found. Can anyone explain this to me?

Also, perhaps I have living with blinders on, but it was only when the other test confirmed B cell lymphoma, Non-Hodgkins Lymphoma, that I figured out that CLL is one of the 6 main sunsets of Non-Hodgkins.

This test confirms that the b-cell destroyer Venetoclax and Rituximab is the best protocol for me!

[gardening-girl]

t2aa, Reading about del5q, I could not find many articles relating it to CLL, but it did seem that having less of CD74 and RPS14 could be a good thing. In one case it was even suggested that anti-CD74 antibody might be a good therapeutic strategy for CLL!

In the case of CD74:

- “CLL cells overexpress both CD74 and its ligand MIF in comparison to healthy B cells.”

- “The surface receptor CD74 has been shown to be an important regulator of B cell survival.”

- “…blocking of CD74 or its ligand MIF, e.g. with an antagonistic anti-CD74 antibody, might inhibit survival of CLL cells and their homing to the bone marrow."

Dissertation Title: Function of the CD74 receptor in B cell pro-survival signaling in the context of chronic lymphocytic leukemia

pdfs.semanticscholar.org/a9...

In the case of RSPS14:

- A decrease in RPS14 has been shown to activate p53, which would seem to be a good thing!

- “Activated p53 then promotes the transcription of its many target genes resulting in p53-dependent cell cycle arrest or apoptosis.”

ncbi.nlm.nih.gov/pmc/articl...

ASLX1 maps to 20q11 and mutations in it are generally associated with myeloid cancers, as are 5q deletions.

If you receive word from your medical team, please let us know what they have to say!

And, I hope you are still doing well following the Venetoclax ramp-up.

gardening-girl

[t2aa in reply to gardening-girl]

Thanks for your reply. Those were the articles I was trying to interpret. I was worried it meant I have myeloid cancer as well, but I have none of those symptoms so that must not be right.

I see my team on Monday when I ramp up to the full dose of Venetoclax. I don’t know when I see my actual doctor next.

I think I’ll email him for answers.

The ramp up is going remarkably well. My lab results are pretty great so far and I feel better than I have in months.

[SeymourB in reply to t2aa]

I think that since these genes have been spotted while researching CML or MDS could certainly increase one's anxiety. But it could be that they were originally found during CML/MDS research, and now that there are these genetic tests, we can see they happen in CLL, too.