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Pelabresib May Represent Optimal Partner for JAK Inhibition in Myelofibrosis
The benefits yielded with the BET inhibitor pelabresib (formerly CPI-0610) in patients with myelofibrosis are multifold, and the agent’s potential to improve disease biology and overcome shortcomings faced with JAK inhibitors make it a strong partner for combinations and a stand-out option vs other agents
The benefits yielded with the BET inhibitor pelabresib (formerly CPI-0610) in patients with myelofibrosis are multifold, and the agent’s potential to improve disease biology and overcome shortcomings faced with JAK inhibitors make it a strong partner for combinations and a stand-out option vs other agents
Manouche
in
MPN Voice
3 years ago
Targeted Therapies for Polycythemia Vera
« Andrew Kuykendall, MD: You bring up a great point there as far as the durability goes, because I have run into a few conversations with folks where there is a concern or some hesitancy to utilize ruxolitinib in the polycythemia vera setting due to concern of using their last gun. “Oh, if I utilize
« Andrew Kuykendall, MD: You bring up a great point there as far as the durability goes, because I have run into a few conversations with folks where there is a concern or some hesitancy to utilize ruxolitinib in the polycythemia vera setting due to concern of using their last gun. “Oh, if I utilize
Manouche
in
MPN Voice
3 years ago
Tocilizumab and coming off prednisolone
Just looking for current advice as regards the usage of tocilizumab as an aid to getting down and off prednisolone. I met a helpful person on this site and he had been on prednisolone for many years - more than my 12 years. He told me his endocrinologist had put him on tocilizumab and he had managed
Just looking for current advice as regards the usage of tocilizumab as an aid to getting down and off prednisolone. I met a helpful person on this site and he had been on prednisolone for many years - more than my 12 years. He told me his endocrinologist had put him on tocilizumab and he had managed
Stkeyna
in
PMRGCAuk
3 years ago
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CLL and Hyperbaric chamber
Hi Diagnosed in 2013 and on W&W but blood tests not so good and expecting to get some sort of treatment soon. Trying out using Hyperbaric Chamber, will do 20 sessions and then drop to 1 per week as advised so will be interesting to compare blood results before and after. Any body had similar experience
Hi Diagnosed in 2013 and on W&W but blood tests not so good and expecting to get some sort of treatment soon. Trying out using Hyperbaric Chamber, will do 20 sessions and then drop to 1 per week as advised so will be interesting to compare blood results before and after. Any body had similar experience
roblaw
in
CLL Support
3 years ago
Sodium / potassium
Sodium intake . Hi a question regarding sodium intake and potassium .I’m on pred 15 mg - I have noticed the days I am not paying attention to diet ( most days Im Good !) but if I eat anything salty !! - ie crisps / chips with salt etc then my fluid balance seems to go completely out of whack - my eyes
Sodium intake . Hi a question regarding sodium intake and potassium .I’m on pred 15 mg - I have noticed the days I am not paying attention to diet ( most days Im Good !) but if I eat anything salty !! - ie crisps / chips with salt etc then my fluid balance seems to go completely out of whack - my eyes
Ballywilliam
in
PMRGCAuk
3 years ago
Campaigns corner: To improve support and understanding of safety needs of blood cancer patients as lockdown lifts
To improve the experience of employed leukaemia patients as the COVID-19 pandemic restrictions lift.
[i]"We have launched the #LifeVsLivelihood campaign to highlight the ongoing challenges that clinically extremely vulnerable leukaemia patients face as restrictions ease and employers ask people
To improve the experience of employed leukaemia patients as the COVID-19 pandemic restrictions lift.
[i]"We have launched the #LifeVsLivelihood campaign to highlight the ongoing challenges that clinically extremely vulnerable leukaemia patients face as restrictions ease and employers ask people
HAIRBEAR_UK
in
Leukaemia Support
3 years ago
Tocilizumab treatment?
A friend of mine recently suggested that I try the monoclonal antibody tocilizumab as a treatment for my PMR. My questions are as follows: Has tocilizumab brought anyone into remission and for how long? On balance, is treatment with tocilizumab preferable to the prednisone that I'm taking now? What is
A friend of mine recently suggested that I try the monoclonal antibody tocilizumab as a treatment for my PMR. My questions are as follows: Has tocilizumab brought anyone into remission and for how long? On balance, is treatment with tocilizumab preferable to the prednisone that I'm taking now? What is
Ozark
in
PMRGCAuk
3 years ago
The Lambda variant is now in 29 countries, but what evidence do we have that it’s more dangerous?
...........................................A variant of interest is one that has mutations that are predicted or known to affect things such as transmissibility (how easily the virus spreads), severity of disease, ability to evade immunity from past infections or vaccines, or confound diagnostic tests
...........................................A variant of interest is one that has mutations that are predicted or known to affect things such as transmissibility (how easily the virus spreads), severity of disease, ability to evade immunity from past infections or vaccines, or confound diagnostic tests
2greys
in
Lung Conditions Community Forum
3 years ago
Ruxolitinib and vaccine efficacy
Has anyone extracted anything useful from the blizzard of recent press coverage and small-scale studies with immunosuppressed individuals, about what exactly is the vaccine efficacy for those of us on Ruxolitinib? I am thoroughly confused and how safe I am now that I’ve been double vaccinated. Can our
Has anyone extracted anything useful from the blizzard of recent press coverage and small-scale studies with immunosuppressed individuals, about what exactly is the vaccine efficacy for those of us on Ruxolitinib? I am thoroughly confused and how safe I am now that I’ve been double vaccinated. Can our
Rob58
in
MPN Voice
3 years ago
Saxenda weight loss medication
I have myelofibrosis and take hydroxycarbamide. Can anyone tell me if there are any reasons why i should not have Saxenda which is a medicine to help you loose weight. Its a GLP1 hormone ( i understand) can anyone point me in the right direction. There are no drug interactions
I have myelofibrosis and take hydroxycarbamide. Can anyone tell me if there are any reasons why i should not have Saxenda which is a medicine to help you loose weight. Its a GLP1 hormone ( i understand) can anyone point me in the right direction. There are no drug interactions
Ginny70
in
MPN Voice
3 years ago
Roactemra Tocilizumab - lab out of stock - advice needed please.
Some of you may remember that I am taking Tocilizumab injections (only) regularly for GCA. Not long ago, others in my situation wrote saying that they had been warned that it was going to run out for a while due to the same drug being used world wide for covid patients. This has happened here in France
Some of you may remember that I am taking Tocilizumab injections (only) regularly for GCA. Not long ago, others in my situation wrote saying that they had been warned that it was going to run out for a while due to the same drug being used world wide for covid patients. This has happened here in France
Frenchduck
in
PMRGCAuk
3 years ago
Captivate Trial MRD status
I've been part of the CAPTIVATE trial since 2018. My treatment ended in May 2019....Ibrutinib for 12 months and Venetoclax for 9. I just received several test results including Flow Citometry and I am still MRD negative after 2 years. This trial was simply awesome and a life saver. I was originally
I've been part of the CAPTIVATE trial since 2018. My treatment ended in May 2019....Ibrutinib for 12 months and Venetoclax for 9. I just received several test results including Flow Citometry and I am still MRD negative after 2 years. This trial was simply awesome and a life saver. I was originally
lamboman
in
CLL Support
3 years ago
A CLL Patient Story Sprinkled with Shakespeare!
A Patient Story Sprinkled with Shakespeare! Doreen Zetterlund, an actress, long-time CLL patient advocate, and member of a CLL Society Support Group, inspires us with her strategy to frontload her CLL knowledge to be certain that she will be well informed as to her best possible care, regardless of how
A Patient Story Sprinkled with Shakespeare! Doreen Zetterlund, an actress, long-time CLL patient advocate, and member of a CLL Society Support Group, inspires us with her strategy to frontload her CLL knowledge to be certain that she will be well informed as to her best possible care, regardless of how
bkoffman
CLL CURE Hero
in
CLL Support
3 years ago
Why my Dr is reducing my pain medication which is effecting my quality of life
I am 45 I got diagnosed with a degenerative disease of my lumbar spine in July 2011. I also have lymphoedema. To cut a long story short I have been through hell and high water to get put on a medication plan to help with my conditions. I am still taking my medication but I am in chronic pain. The problems
I am 45 I got diagnosed with a degenerative disease of my lumbar spine in July 2011. I also have lymphoedema. To cut a long story short I have been through hell and high water to get put on a medication plan to help with my conditions. I am still taking my medication but I am in chronic pain. The problems
Daz75
in
Pain Concern
3 years ago
Why my Dr is reducing my medication which is effecting my quality of life
I am 45 I got diagnosed with a degenerative disease of my lumbar spine in July 2011. I also have lymphoedema. To cut a long story short I have been through hell and high water to get put on a medication plan to help with my conditions. I am still taking my medication but I am in chronic pain. The problems
I am 45 I got diagnosed with a degenerative disease of my lumbar spine in July 2011. I also have lymphoedema. To cut a long story short I have been through hell and high water to get put on a medication plan to help with my conditions. I am still taking my medication but I am in chronic pain. The problems
Daz75
in
Action on Pain
3 years ago
Probiotics, MF and Ruxolitinib
Just something that came up while I was chatting briefly to my haematology nurse. I asked her if taking probiotics was a good idea for me, fully expecting her to say yes. However, it was a definite no, because my gut bacteria will not be the normal mixture. We didn't continue the conversation as she
Just something that came up while I was chatting briefly to my haematology nurse. I asked her if taking probiotics was a good idea for me, fully expecting her to say yes. However, it was a definite no, because my gut bacteria will not be the normal mixture. We didn't continue the conversation as she
Otterfield
in
MPN Voice
3 years ago
Weight gain with ruxolitinib
Hi can anyone help please? I've been on ruxolitinib since November and my weight is creeping up. I have always eaten well and exercise alot but this change is getting me down. If anyone has any advice I'd really appreciate it, thanks all x
Hi can anyone help please? I've been on ruxolitinib since November and my weight is creeping up. I have always eaten well and exercise alot but this change is getting me down. If anyone has any advice I'd really appreciate it, thanks all x
soomoo
in
MPN Voice
3 years ago
First Stem Cell Transplant Appointment done
Thanks to everyone who replied to my first post on this. My husband and I stayed over in Southampton and we got home today. To my great relief, the consultant was extremely approachable and excellent at explaining things. I didn't ask all of my questions as these initial discussions are being done over
Thanks to everyone who replied to my first post on this. My husband and I stayed over in Southampton and we got home today. To my great relief, the consultant was extremely approachable and excellent at explaining things. I didn't ask all of my questions as these initial discussions are being done over
Otterfield
in
MPN Voice
3 years ago
Treatment and ocular lymphocytic leukemia
My diagnosis in 2017Trisomy12 unmutated 500000 wbc 397 absolute lymphocite Count 6.1 hemoglobin I joined a threefold trial Ibrutinib, Obinutuzumab and Venetoclax. When I had uveitis on both eyes I felt it was temporarily but treatment was necessary. I didnt know then that there is ocular CLL and that
My diagnosis in 2017Trisomy12 unmutated 500000 wbc 397 absolute lymphocite Count 6.1 hemoglobin I joined a threefold trial Ibrutinib, Obinutuzumab and Venetoclax. When I had uveitis on both eyes I felt it was temporarily but treatment was necessary. I didnt know then that there is ocular CLL and that
mickimauser11
in
CLL Support
3 years ago
Study shows low or undetectable immune response to double COVID-19 vaccination in patients with impaired immune systems
The first data from the ongoing OCTAVE (Observational Cohort Trial-T-cells Antibodies and Vaccine Efficacy in SARS-CoV-2) study show that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions mount a low or undetectable immune response after
The first data from the ongoing OCTAVE (Observational Cohort Trial-T-cells Antibodies and Vaccine Efficacy in SARS-CoV-2) study show that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions mount a low or undetectable immune response after
2greys
in
Lung Conditions Community Forum
3 years ago
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