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Abiraterone/enzalutamide+PARP inhibitor better than abiraterone/enzalutamide alone for mCRPC, even without BRCA+
A new therapy may be approved next month for all men with mCRPC. Previously, PARP inhibitors were only approved for men with mutations in the BRCA gene (BRCA+) and a few other rare similar mutations. By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone
A new therapy may be approved next month for all men with mCRPC. Previously, PARP inhibitors were only approved for men with mutations in the BRCA gene (BRCA+) and a few other rare similar mutations. By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
6 rounds of chemo before surgery HGSC
Hi everyone, has anyone had 6 rounds of chemo prior to surgery? My mum has high grade serous, not sure which stage, I think she is stage 3 at least, but now I’m worried she is stage 4 because the doctors want to do 6 rounds of chemo instead of 3 before surgery. They have said her gall bladder and spleen
Hi everyone, has anyone had 6 rounds of chemo prior to surgery? My mum has high grade serous, not sure which stage, I think she is stage 3 at least, but now I’m worried she is stage 4 because the doctors want to do 6 rounds of chemo instead of 3 before surgery. They have said her gall bladder and spleen
Shorty18
in
My Ovacome
1 year ago
CA 125… waitting CT
the story, my mom has 2nd recurrance may-sept she get carbo+taxol 8 treatments ca 125 was down from 350 to 40, some lymph was "suriver"after that but doctor sent her for watch and wait. after 2 month her ca was up to 95, after 3 month from last chemo 230 and now 5 month after chemo it is 370. if i count
the story, my mom has 2nd recurrance may-sept she get carbo+taxol 8 treatments ca 125 was down from 350 to 40, some lymph was "suriver"after that but doctor sent her for watch and wait. after 2 month her ca was up to 95, after 3 month from last chemo 230 and now 5 month after chemo it is 370. if i count
Inguc_is
in
My Ovacome
1 year ago
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Rise in CA125
Hi ladies, Hope you're all well! My Mum has really had a bit of a knock back after being told of a rise in her CA125 levels. It was 16, then 22, and now shot up to 92. She's stage 4 borderline, had 6x chemo, optimal debulking surgery, and was declared NED August last year — she's also completing a year
Hi ladies, Hope you're all well! My Mum has really had a bit of a knock back after being told of a rise in her CA125 levels. It was 16, then 22, and now shot up to 92. She's stage 4 borderline, had 6x chemo, optimal debulking surgery, and was declared NED August last year — she's also completing a year
georgialocksss
in
My Ovacome
1 year ago
Allogenic Stem Cell Transplant
I [i]received a Stem cell transplant six months ago. My decision was based on the availability of a suitable donor and being able to get to remission through aggressive chemotherapy. Other treatments had no effect on my rapidly growing leukemia. As of today I’m still in remission, showing 97% chimerism
I [i]received a Stem cell transplant six months ago. My decision was based on the availability of a suitable donor and being able to get to remission through aggressive chemotherapy. Other treatments had no effect on my rapidly growing leukemia. As of today I’m still in remission, showing 97% chimerism
GarciaB
in
MPN Voice
2 years ago
Tailbone Spasms from Neulasta
After my second dose of chemo (Docetaxel), I ended up in the ER with a fever. My white blood cell count was 1.2 K/CMM and Neutrophils were 0 K/CMM (!). Anyway, I was approved for Neulasta and had the injection 24 hours after my 3rd chemo infusion. Six days later I woke up with horrible pain and spasms
After my second dose of chemo (Docetaxel), I ended up in the ER with a fever. My white blood cell count was 1.2 K/CMM and Neutrophils were 0 K/CMM (!). Anyway, I was approved for Neulasta and had the injection 24 hours after my 3rd chemo infusion. Six days later I woke up with horrible pain and spasms
carguy
in
Advanced Prostate Cancer
2 years ago
Chemo brain
Hi does anybody else struggle with what is called chemo brain?
Hi does anybody else struggle with what is called chemo brain?
Platelets2022
in
Leukaemia Support
2 years ago
PSA after SBRT to T7
A recent PET/PSMA showed a single PC tumor on T7. My PSA at the time was 1.1 I was initially treated 5 years ago with ADT, Radiation to prostate and chemo and my PSA nadir was in the range of .6 to .8 over the last few years. My recent SBRT treatment was 45 gray over 5 treatments. One month after
A recent PET/PSMA showed a single PC tumor on T7. My PSA at the time was 1.1 I was initially treated 5 years ago with ADT, Radiation to prostate and chemo and my PSA nadir was in the range of .6 to .8 over the last few years. My recent SBRT treatment was 45 gray over 5 treatments. One month after
billd50
in
Advanced Prostate Cancer
2 years ago
Exon20 mutation and Mobocertinib
Hi , after the usual ‘standard’ chemo and immunotherapy ( which seriously impacted on my kidney function and had to be stopped ) I have now been diagnosed with Exon20 mutation and offered Mobocertinib . This is exactly a year after my initial diagnosis . My stage 4 adenocarcinoma and bony secondaries
Hi , after the usual ‘standard’ chemo and immunotherapy ( which seriously impacted on my kidney function and had to be stopped ) I have now been diagnosed with Exon20 mutation and offered Mobocertinib . This is exactly a year after my initial diagnosis . My stage 4 adenocarcinoma and bony secondaries
WoolleySunshine
in
The Roy Castle Lung Cancer Foundation
2 years ago
Newbie !
Hi, I am new here. I was diagnosed with Stage 3C1 cervical cancer March 2021. I had 27 radiotherapy sessions, 5 chemotherapy sessions and 3 high dose brachytherapy sessions. My bowel issues started very early on and got worse and worse as treatment went on. I finished active treatment on 29th July. I
Hi, I am new here. I was diagnosed with Stage 3C1 cervical cancer March 2021. I had 27 radiotherapy sessions, 5 chemotherapy sessions and 3 high dose brachytherapy sessions. My bowel issues started very early on and got worse and worse as treatment went on. I finished active treatment on 29th July. I
Dasch123
in
Pelvic Radiation Disease Association
2 years ago
rise in ca125
hi I had surgery 4 years ago to remove everything including my cervix, 2 years ago I started bleeding which turned out to be 2 Lgc in surgery the found another tumour on my uretha which the had to cut part of this way, after which I had chemo carcinoma and taxol. now my issue is in October my ca125
hi I had surgery 4 years ago to remove everything including my cervix, 2 years ago I started bleeding which turned out to be 2 Lgc in surgery the found another tumour on my uretha which the had to cut part of this way, after which I had chemo carcinoma and taxol. now my issue is in October my ca125
Heidi1965
in
My Ovacome
2 years ago
What to do?
I know that continuing with chemo is a personal thing, and that it has to be my decision, but I have no one else, who understands, to discuss this with.I had my first chemo, Carbo/Taxel in 2016,, and since then have had Avastin, Carbo/Caelyx, Rucaparib and weekly Taxel, which I finished just before Christmas
I know that continuing with chemo is a personal thing, and that it has to be my decision, but I have no one else, who understands, to discuss this with.I had my first chemo, Carbo/Taxel in 2016,, and since then have had Avastin, Carbo/Caelyx, Rucaparib and weekly Taxel, which I finished just before Christmas
27-359
in
My Ovacome
2 years ago
Former art teacher with a passion for travel
Former art teacher. I started traveling in my fifties and it became my passion (I’ve visited 41 countries so far!) until Covid and then my stage 4 diagnosis came. Diagnosed with IDC stage 3 in 2015. My great-grandmother had breast cancer in the 1920s, and an aunt had it when she was in her mid-eighties
Former art teacher. I started traveling in my fifties and it became my passion (I’ve visited 41 countries so far!) until Covid and then my stage 4 diagnosis came. Diagnosed with IDC stage 3 in 2015. My great-grandmother had breast cancer in the 1920s, and an aunt had it when she was in her mid-eighties
Chamisa
in
SHARE Metastatic Breast Cancer
2 years ago
Man's Prostate Cancer Caused "Uncontrollable" Irish Accent, Doctors Say
HEY, someone has to post the important papers. Man's Cancer Caused "Uncontrollable" Irish Accent, Doctors Https://futurism.com/neoscope/cancer-irish-accent In a truly bizarre case, doctors have documented for the first time a man who appears to have developed a random Irish accent after getting
HEY, someone has to post the important papers. Man's Cancer Caused "Uncontrollable" Irish Accent, Doctors Https://futurism.com/neoscope/cancer-irish-accent In a truly bizarre case, doctors have documented for the first time a man who appears to have developed a random Irish accent after getting
cesces
in
Advanced Prostate Cancer
2 years ago
Hi all I’ve not been here for nearly 3 months time has disappeared recently. Last time here was the night before my surgery.
Surgery was ok ( In hindsight ! ). total hysterectomy bilateral salpingoophrectomy .., they took my appendix and also omentum. Histology came back as Stage 1c2 mucinous adenocarcinoma . Was suspected ( as most mucinous are ) that it was a secondary tumour from GI origin ( stomach / bowel) I’ve had
Surgery was ok ( In hindsight ! ). total hysterectomy bilateral salpingoophrectomy .., they took my appendix and also omentum. Histology came back as Stage 1c2 mucinous adenocarcinoma . Was suspected ( as most mucinous are ) that it was a secondary tumour from GI origin ( stomach / bowel) I’ve had
Deli44
in
My Ovacome
2 years ago
chemo fatigue any help out there
my husband had round 9 and last of cabitaxel two weeks ago He cannot hardly stay awake for more than a few minutes and can go nowhere and can’t even think straight We are flying from Scotland to London for scans next Monday for pre Lutetium treatment Not sure he will be up to it Say thing I can
my husband had round 9 and last of cabitaxel two weeks ago He cannot hardly stay awake for more than a few minutes and can go nowhere and can’t even think straight We are flying from Scotland to London for scans next Monday for pre Lutetium treatment Not sure he will be up to it Say thing I can
Hidden
in
Advanced Prostate Cancer
2 years ago
My battle with castration resistant metastatic prostate cancer that had spread to the bones since 2021
What do I need to do after biopsy, surgery, chemotherapy, Abiraterone treatment and ailment seems to progress as I am always in intense pain and sleepless nights? My PSA hovers above 100.
What do I need to do after biopsy, surgery, chemotherapy, Abiraterone treatment and ailment seems to progress as I am always in intense pain and sleepless nights? My PSA hovers above 100.
emmaokeke
in
Advanced Prostate Cancer
2 years ago
Any advice about future treatment?
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Good morning sisters, I am at yet another crossroads and hoping for some advice. Diagnosed stage 4 high grade serous Jan 2020, had two surgeries, three courses of chemo (in total), short lived Niraparib, failed clinical trial (PICCOLO). So now having the 6th and final chemo of this third course ( Carboplatin
Riverflo
in
My Ovacome
2 years ago
Niraparib and eyelashes
Hi, I am wondering if anyone else has noticed that their eyelashes are only little stumps of lashes? My eyelashes grew back lovely and long after I finished my Chemo in June 2022. I have been on Niraparib since July but noticed this last few weeks my eyelashes have gotten shorter. Is this a side
Hi, I am wondering if anyone else has noticed that their eyelashes are only little stumps of lashes? My eyelashes grew back lovely and long after I finished my Chemo in June 2022. I have been on Niraparib since July but noticed this last few weeks my eyelashes have gotten shorter. Is this a side
babs1120
in
My Ovacome
2 years ago
Chemo round 2 - fingernail beds feel bruised
This isn’t how I pictured neuropathy feeling, that would be numbness or pins and needles, correct? Yesterday I noticed pressing on my fingernail caused a bruising feeling. Today some of the fingernail beds just ache a little, and feel bruised when touched. It’s obviously from chemo, is there a name
This isn’t how I pictured neuropathy feeling, that would be numbness or pins and needles, correct? Yesterday I noticed pressing on my fingernail caused a bruising feeling. Today some of the fingernail beds just ache a little, and feel bruised when touched. It’s obviously from chemo, is there a name
Gl448
in
Advanced Prostate Cancer
2 years ago
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