Experiences with

Madopar

was hoping someone could help my husband is very stiff is taking sinemet but didn’t seem to be helping the Parkinson’s nurse is trying him on madopar with sinemet as fast acting for moving him carers think has made him a bit less stiff but he is getting lots of facial movements and eyes are very sore

has anyone tried Madopar quick release under the tongue ie; split the capsule open and poured the contents under the tongue? (Sublingual)….Did it absorb through the tissue under the tongue and provide relief quickly?

I was on just Madopar every three hours, but I was only feeling OK for one hour out of three and had very, very little energy.

I'm wondering if this might be easier than the Madopar

I take Madopar 5omg every 90mins to 2 hourly intervals.....7 or 8 per day ,and 2 or 3 100mg controlled release before meals and overnight, leaving 3 to 5 hours between the next dose when taken at night , though I think stacking occurs when I use the c/r at lunch time.

The Madopar he has been taking, along with Amantadine, for the past 6 months do not appear to have made any difference. Has anyone any experience of taking LionsMane supplements and which ‘may’ make a difference to the brain. He also takes a small dose aspirin as a blood thinner. Any thoughts?

My wife Sue was initially diagnosed with Parkinson's in September 2023 and put on madopar. The dosage has been increased over that time but she appears to be getting no relief. Her neurologist said she might have msa but can't be certain.

Started off with neupro patches but over the years mainly ropinerole, stalevo , madopar and at night rivotril. I’ve recently heard one of the neurologist mentioning Parkin when he was looking through My file….what is the difference THANKYOU KIND REGARDS

it won't go away with increased madopar dose. I am not sure my muscle spasm/ dystonia is caused by levodopa itself or amandatine. anyone has experience?

This happens every time I take madopar Immediate Release, which is seven times a day. I also experience chest tightness which really scares me. I was wondering if there are other people who live with PD and have experienced similar challenges.

In March 2025, I reached a dose of 4 Madopar pills (200/50) at 4-hour intervals. Because Madopar became unavailable in Romania, I had to change the medication to ISICOM (Levodopa 250 mg / Carbidopa 25 mg) of which I now take 3 pills every day at 5-hour intervals.

On Madopar for Parkinson's and it helps my RLS. Currently just on a low dose, but without it the RLS would be unbearable. I read about augmentation but what do I do as I have Parkinson's?

I went to bed and was conscious of being hot and dyskinetic despite not having overdosed on Madopar as far as I know.

Initially started on one or two 12.5/50 Madopar over night with sporadic ones through the day. Fast forward to a week ago I was taking one 12.5/50 Madopar and one 100mg Mucuna (Source Naturals), every three hours otherwise I am extremely uncomfortable.

I am currently prescribed Madopar, and unable to take sinimet due to worsening side effects. I have also recently been prescribed pregabalin but i don’t seem to be getting any relief from it.

I currently take 8 capsules of 50mg/12.5mg madopar. I have previously been told by my old Parkinson’s nurse that this was a low dose leaving room to increase it when required but have now been told that this is a high dose by a different Parkinson’s nurse. And they don’t want to increase it.

I'm on daily madopar 100mg, 3 times and day and 6mg neupro. Could this be meds even though I've been fine for 9 months or is this a sign of progression? I read that gastroparesis is common in PD but not seen lots discussed about it. All feedback and thoughts appreciated :)

She says the only thing that helps is madopar and she takes that at night. But sometimes she takes one earlier and one later at night. It knocks her out just enough to sleep 2 to 4 hours. She says she has been bad for days.

I actually take madopar 125 mg at 08am /11am / 2pm / 5pm / 8pm / 11pm / 3am Thanks Marc

My PWP suffers at times with severe anxiety and fear that seems to interfere with the efficacy of her madopar doses (175mg 5 times a day). She's off more than on at present.