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Three-drug GIV combo promising against high-risk CLL - Patients with deletion 17p or TP53 (from EHA Congress)
[i]For patients with high-risk chronic
lymphocytic
leukemia
(CLL), first-line therapy with a triple combination of targeted agents obinutuzumab (Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) showed encouraging response rates in the phase 2 CLL2-GIVe trial.
[i]For patients with high-risk chronic
lymphocytic
leukemia
(CLL), first-line therapy with a triple combination of targeted agents obinutuzumab (Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) showed encouraging response rates in the phase 2 CLL2-GIVe trial.
AussieNeil
Partner
in
CLL Support
4 years ago
Immunophenotyping
Hi, just got my result from immunophenotying said it show classic 5 of 5 for CLL do not know what that means diagnosed with SLL in December 2016. have had doubling of lymphocytes and WBC since March this year and also some night sweat very easily fatigued, should be starting Acalabrutinib shortly seeing
Hi, just got my result from immunophenotying said it show classic 5 of 5 for CLL do not know what that means diagnosed with SLL in December 2016. have had doubling of lymphocytes and WBC since March this year and also some night sweat very easily fatigued, should be starting Acalabrutinib shortly seeing
jaybrjod
in
CLL Support
4 years ago
Axi-Cel (anti-CD19 CAR T-cell therapy FMC63-28Z) Induces Durable Remissions in Relapsed CLL, B-Cell Lymphoma
[i]Patients with relapsed chronic
lymphocytic
leukemia
(CLL) and B-cell lymphoma who received the anti-CD19 CAR T-cell therapy FMC63-28Z, which was later developed as axicabtagene ciloleucel (axi-cel; Yescarta), experienced highly durable rates of remission, according to long-term data from a phase 1
[i]Patients with relapsed chronic
lymphocytic
leukemia
(CLL) and B-cell lymphoma who received the anti-CD19 CAR T-cell therapy FMC63-28Z, which was later developed as axicabtagene ciloleucel (axi-cel; Yescarta), experienced highly durable rates of remission, according to long-term data from a phase 1
AussieNeil
Partner
in
CLL Support
4 years ago
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We are mutating SARS-CoV-2, but it is evolving back.
Scientists investigating the evolution of the virus that causes Covid19 say that its mutation seems to be directed by human proteins that degrade it, but natural selection of the virus enables it to bounce back. The findings could help in the design of vaccines against the virus. All organisms mutate
Scientists investigating the evolution of the virus that causes Covid19 say that its mutation seems to be directed by human proteins that degrade it, but natural selection of the virus enables it to bounce back. The findings could help in the design of vaccines against the virus. All organisms mutate
2greys
in
Lung Conditions Community Forum
4 years ago
Join CLL Society & CancerCare for Connect Workshop call focusing on Caregivers tomorrow!
Join CLL Society’s Patty Koffman, Lindsey Roeker MD, Stewart Fleishman MD, Sharon Flynn RN, and Carolyn Messner, DSW and CancerCare Coping with the Stresses of Caregiving When Your Loved One Has Chronic
Lymphocytic
Leukemia
(CLL) Register here: https://www.cancercare.org/connect_workshops/817-coping_with_the_stresses_of_caregiving_when_your_loved_one_has_chronic_lymphocytic_leukemia
Join CLL Society’s Patty Koffman, Lindsey Roeker MD, Stewart Fleishman MD, Sharon Flynn RN, and Carolyn Messner, DSW and CancerCare Coping with the Stresses of Caregiving When Your Loved One Has Chronic
Lymphocytic
Leukemia
(CLL) Register here: https://www.cancercare.org/connect_workshops/817-coping_with_the_stresses_of_caregiving_when_your_loved_one_has_chronic_lymphocytic_leukemia
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
COVID-19 vaccine has hefty response in nonhuman primates
A replicating RNA vaccine, formulated with a lipid-based nanoparticle emulsion that goes by the acronym LION, produces antibodies against the COVID-19 coronavirus in mice and primates with a single immunization. These antibodies potently neutralize the virus. The effects occurred within two weeks after
A replicating RNA vaccine, formulated with a lipid-based nanoparticle emulsion that goes by the acronym LION, produces antibodies against the COVID-19 coronavirus in mice and primates with a single immunization. These antibodies potently neutralize the virus. The effects occurred within two weeks after
2greys
in
Lung Conditions Community Forum
4 years ago
Blood results in CBC
Hi All, I wrote two months ago that my blood work had returned to normal after two abnormal and a tentative dx of CLL. Well, this month it is abnormal again. I am so confused. The receptionist said they never diagnose until at least six months of blood results.
Hi All, I wrote two months ago that my blood work had returned to normal after two abnormal and a tentative dx of CLL. Well, this month it is abnormal again. I am so confused. The receptionist said they never diagnose until at least six months of blood results.
gustave
in
CLL Support
4 years ago
Free Prescription home deliveries appear to have been stopped by Boots
Since the start of lockdown my local Boots pharmacy has been efficiently delivering my prescriptions to my front door. Latest was sent my GP to them 2 weeks ago. I rang today and was told as the Government had stopped support for the vulnerable, they has stopped free deliveries. The very nice manager
Since the start of lockdown my local Boots pharmacy has been efficiently delivering my prescriptions to my front door. Latest was sent my GP to them 2 weeks ago. I rang today and was told as the Government had stopped support for the vulnerable, they has stopped free deliveries. The very nice manager
Harvist
in
CLL Support
4 years ago
SLL/CLL Numbers
Thanks for all of you with your previous replies. As you know I have been diagnosed last month with SLL/CLL and now I have all my test results. I hope you can share your experience with similar results to mine and dice me with what to expect: 1) CBC all numbers are within the normal range 2) Flow
Thanks for all of you with your previous replies. As you know I have been diagnosed last month with SLL/CLL and now I have all my test results. I hope you can share your experience with similar results to mine and dice me with what to expect: 1) CBC all numbers are within the normal range 2) Flow
Egypt58
in
CLL Support
4 years ago
T cell leukemia
Just diagnosed with T cell leukemia, I do not have a subtype yet. Any other T cell types out there?
Just diagnosed with T cell leukemia, I do not have a subtype yet. Any other T cell types out there?
Mom-mom-e
in
CLL Support
4 years ago
Imbruvica-related issues: Qs + comments
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
Pogee
in
CLL Support
4 years ago
FCR
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
Rccfrc00
in
CLL Support
4 years ago
flair ..fcr
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
kel555
in
CLL Support
4 years ago
Documented remission without drugs
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
Pogee
in
CLL Support
4 years ago
Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? - Not necessarily. The BTK inhibitors are excellent at....
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
lankisterguy
Volunteer
in
CLL Support
4 years ago
Resistance-Associated Mutations in CLL Patients Treated With Novel Agents
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
Jm954
Administrator
in
CLL Support
4 years ago
Richter transformation after quitting ibrutinib: a diagnostic error
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Priss69
in
CLL Support
4 years ago
FDA approves ibrutinib plus rituximab for chronic lymphocytic leukemia
https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-ibrutinib-plus-rituximab-chronic-
lymphocytic
-
leukemia
?fbclid=IwAR02tCtziW0mkgktq3Pg_o5drjFaH1xYBYArkn4ZlVicIo7pVzStrrFKWs4
https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-ibrutinib-plus-rituximab-chronic-
lymphocytic
-
leukemia
?fbclid=IwAR02tCtziW0mkgktq3Pg_o5drjFaH1xYBYArkn4ZlVicIo7pVzStrrFKWs4
chickenandwaffles
in
CLL Support
4 years ago
CSIRO uses lab-grown ‘lungs’ to fight respiratory viruses
Researchers at Australia's national science agency, CSIRO, found that lab-grown cells from the upper layer of the airway to the lungs – the human bronchial epithelium – reliably mimic a live person's airway's response to viruses. CSIRO Research Scientist Dr Elizabeth Pharo is the lead author on the findings
Researchers at Australia's national science agency, CSIRO, found that lab-grown cells from the upper layer of the airway to the lungs – the human bronchial epithelium – reliably mimic a live person's airway's response to viruses. CSIRO Research Scientist Dr Elizabeth Pharo is the lead author on the findings
2greys
in
Lung Conditions Community Forum
4 years ago
Illuminating novel biological aspects and potential new therapeutic approaches for chronic myeloproliferative malignancies
Abstract This review reflects the presentations and discussion at the 14th post‐ASH International Workshop on Chronic Myeloproliferative Malignancies, which took place on the 10th‐11th December 2019, immediately after the 61st American Society of Hematology (ASH) Annual Meeting in Orlando, Florida. Rather
Abstract This review reflects the presentations and discussion at the 14th post‐ASH International Workshop on Chronic Myeloproliferative Malignancies, which took place on the 10th‐11th December 2019, immediately after the 61st American Society of Hematology (ASH) Annual Meeting in Orlando, Florida. Rather
Manouche
in
MPN Voice
4 years ago
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