Immunophenotyping

[jaybrjod]

Hi, just got my result from immunophenotying said it show classic 5 of 5 for CLL

do not know what that means diagnosed with SLL in December 2016. have had doubling of lymphocytes and WBC since March this year and also some night sweat very easily fatigued, should be starting Acalabrutinib shortly seeing Consultant tomorrow.

[lankisterguy Volunteer]

The simple version is that your cancerous white cells need to have certain proteins on their surface in order to be confirmed as CLL cells and not another Leukemia or Lymphoma

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Here is the MedSpeak version: pubmed.ncbi.nlm.nih.gov/248...

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SNIP Accurate diagnosis of chronic lymphocytic leukemia (CLL) requires immunophenotyping by flow cytometry in order to facilitate differential diagnosis between CLL and other mature B-cell neoplasms (MBCN).

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....characteristic immunophenotype which differentiates CLL from other MBCN is defined by following marker combination--

CD19+

CD20(+Iow)

CD22(+low)

CD5(+high)

CD23+

FMC7-

CD79b(+Iow)

sIg(+Iow)

CLL score values of 5 or 4 points are highly suggestive for diagnosis of CLL.

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Len

[jaybrjod in reply to lankisterguy]

Thank you so much for explaining this to me

[AussieNeil Partner Administrator]

I'd add to Len's reply that CLL and SLL are the same disease; so the immunophenotyping results for CLL and SLL are identical. It's just that historically SLL was diagnosed by pathologists (from a node biopsy) and CLL by haematologists (from a blood test). Acalabrutinib kills CLL/SLL cells in the blood and nodes.

Neil

[jaybrjod in reply to AussieNeil]

Thank you for the explanation, it will all go in one day

[SamanthaJane123 in reply to AussieNeil]

Neil, I appreciate the add on about SLL. While I know they are the same disease, I am always interested in learning about the differences and appreciate when SLL is represented. Thank you.