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Transdermal estrogen/estradiol as monotherapy for Prostate Cancer
Does anyone know of recent studies, clinical trials or Standard of Care (SoC) protocols using or studying estrogen gels, sprays, ointments or patches as hormone therapy for Prostate Cancer, particularly micrometastatic cancer that has not spread beyond the pelvic region? I am in discussions with my
Does anyone know of recent studies, clinical trials or Standard of Care (SoC) protocols using or studying estrogen gels, sprays, ointments or patches as hormone therapy for Prostate Cancer, particularly micrometastatic cancer that has not spread beyond the pelvic region? I am in discussions with my
Lost_Sheep
in
Prostate Cancer Network
2 months ago
The paradigm has shifted - castrate resistance.
It now appears that I’ve entered the land of castrate resistance and further ADT vacations are no longer in the plan. My T level recovered much more quickly during the last vacation than during previous vacations, and my PSA rose correspondingly. At 4 months my T level was 325 and my PSA was 4. Another
It now appears that I’ve entered the land of castrate resistance and further ADT vacations are no longer in the plan. My T level recovered much more quickly during the last vacation than during previous vacations, and my PSA rose correspondingly. At 4 months my T level was 325 and my PSA was 4. Another
fireandice123
in
Advanced Prostate Cancer
2 months ago
Actemra
hi I started the injection on Tuesday and haven’t felt right since. Lightheaded dizzy at times and on and of sickness. Has anyone els had side effects from this, and how long did they last. Iv been on a lot of injections for RA but my body seems to reject them I’m just hoping this isn’t the case and
hi I started the injection on Tuesday and haven’t felt right since. Lightheaded dizzy at times and on and of sickness. Has anyone els had side effects from this, and how long did they last. Iv been on a lot of injections for RA but my body seems to reject them I’m just hoping this isn’t the case and
Larachez2102
in
NRAS
6 months ago
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Life Expectancy
My father was diagnosed with advanced prostate cancer four years ago. Initially, he underwent radiation for a few spots on his ribs and immediately began ADT/Xtandi treatment for two years. His PSA dropped to 0.001, prompting his medical oncologist to recommend a medication vacation. For two years, he
My father was diagnosed with advanced prostate cancer four years ago. Initially, he underwent radiation for a few spots on his ribs and immediately began ADT/Xtandi treatment for two years. His PSA dropped to 0.001, prompting his medical oncologist to recommend a medication vacation. For two years, he
godhelpus
in
Advanced Prostate Cancer
2 months ago
Effect of Baseline T on T-Recovery Time
Here's a plot of % of Men who recover their baseline testosterone after stopping ADT (Lupron), as a function of ADT duration for two different groups: (A) men who had a
normal
baseline testosterone (red line), and (B) men who had a
low
baseline testosterone (green line). Increasing the
Here's a plot of % of Men who recover their baseline testosterone after stopping ADT (Lupron), as a function of ADT duration for two different groups: (A) men who had a
normal
baseline testosterone (red line), and (B) men who had a
low
baseline testosterone (green line). Increasing the
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery for 50% of Men
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron ADT, as a function of ADT duration. For ADT durations less than 20 months, the curve is basically linear with a slope = 1.0 (green line), meaning that the Recovery Time for 50% of men is roughly equal to the ADT
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron ADT, as a function of ADT duration. For ADT durations less than 20 months, the curve is basically linear with a slope = 1.0 (green line), meaning that the Recovery Time for 50% of men is roughly equal to the ADT
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery After ADT - Updated Plot
Thanks to Tall_Allen for providing lots of extra data for this plot: https://www.prostatecancer.news/2023/04/intermittent-adt.html You can easily extrapolate the curves to find out your recovery time. ADT duration of 3-9 months fall roughly on the same curve, and ADT of 18-24 roughly fall on the same
Thanks to Tall_Allen for providing lots of extra data for this plot: https://www.prostatecancer.news/2023/04/intermittent-adt.html You can easily extrapolate the curves to find out your recovery time. ADT duration of 3-9 months fall roughly on the same curve, and ADT of 18-24 roughly fall on the same
janebob99
in
Prostate Cancer Network
2 months ago
Help! on Pro-stap, tibolone HRT brought back endo pain!? Made me so unwell - anyone relate??
pro-stap monthly injections started November without HRT. Reduced lot of the endo pain (although made my stomach issues/sensitivity to food way worse). Decided to start tibolone HRT 10 weeks into the injections and it caused awful period/endo pain, spotting, flu type symptoms on and off. Only lasted
pro-stap monthly injections started November without HRT. Reduced lot of the endo pain (although made my stomach issues/sensitivity to food way worse). Decided to start tibolone HRT 10 weeks into the injections and it caused awful period/endo pain, spotting, flu type symptoms on and off. Only lasted
Flewks
in
Endometriosis UK
2 months ago
FDA approves niraparib and abiraterone acetate plus prednisone for BRCA-mutated metastatic castration-resistant prostate cancer - 08/11/2023
On August 11, 2023, the Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined
On August 11, 2023, the Food and Drug Administration approved the fixed dose combination of niraparib and abiraterone acetate (Akeega, Janssen Biotech, Inc.), with prednisone, for adult patients with deleterious or suspected deleterious BRCA-mutated castration-resistant prostate cancer (mCRPC), as determined
cujoe
in
Fight Prostate Cancer
9 months ago
Testosterone recovery after stopping ADT - 3
This plot shows the % of men who recovered their original testosterone level after stopping Lupron ADT, plotted versus the time (months) after stopping ADT, for three different durations of ADT (4, 6-12, or 24 months). The curves show that a short course of ADT allows men to recover their testosterone
This plot shows the % of men who recovered their original testosterone level after stopping Lupron ADT, plotted versus the time (months) after stopping ADT, for three different durations of ADT (4, 6-12, or 24 months). The curves show that a short course of ADT allows men to recover their testosterone
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery after stopping ADT -2
This plot shows the time after stopping Lupron ADT for the testosterone to recover to the original level for 50% of men, plotted versus Duration of ADT treatment (4 or 24 months). The longer the duration of ADT, the longer it takes to recover the original testosterone level, which makes sense. For
This plot shows the time after stopping Lupron ADT for the testosterone to recover to the original level for 50% of men, plotted versus Duration of ADT treatment (4 or 24 months). The longer the duration of ADT, the longer it takes to recover the original testosterone level, which makes sense. For
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery after stopping ADT -1
Here's the first of four plots showing testosterone recovery after stopping Lupron ADT. The testosterone recovers quickest in the first 12 months, but then flattens out after that.
Here's the first of four plots showing testosterone recovery after stopping Lupron ADT. The testosterone recovers quickest in the first 12 months, but then flattens out after that.
janebob99
in
Prostate Cancer Network
2 months ago
Thoughts on Denosumab in my case
MO is suggesting Denosumab after my Dexa scan. Bone density normal in spine, osteopenia in right hip and osteoporosis on one part of left hip. I am wondering if with a -2.7 it is possible to control/improve with supplements and weight bearing exercises? What are you taking? Have added calcium. The
MO is suggesting Denosumab after my Dexa scan. Bone density normal in spine, osteopenia in right hip and osteoporosis on one part of left hip. I am wondering if with a -2.7 it is possible to control/improve with supplements and weight bearing exercises? What are you taking? Have added calcium. The
Hope49823
in
Advanced Prostate Cancer
2 months ago
PSMA PET Scan Frequency?
Hello forum members. This is my first post but have learned so much here, thanks to the contributors on this site. My husband’s last and only PSMA PET scan was 1.5 years ago showing 6 mets in small bones after PSA consistently rose a year after radiation. The standard ADT treatment was prescribed
Hello forum members. This is my first post but have learned so much here, thanks to the contributors on this site. My husband’s last and only PSMA PET scan was 1.5 years ago showing 6 mets in small bones after PSA consistently rose a year after radiation. The standard ADT treatment was prescribed
EatLovePray
in
Advanced Prostate Cancer
2 months ago
A Neophyte's Experience with a Gummy
Some of you might be interested in my gummy experience. I do not advocate anything here, but just want to share a new experience. Outside of four episodes in my eighty-four plus years, I have not used marijuana or other drugs beyond alcohol, coffee, maté from the Pampas of Argentina, and whatever uppers
Some of you might be interested in my gummy experience. I do not advocate anything here, but just want to share a new experience. Outside of four episodes in my eighty-four plus years, I have not used marijuana or other drugs beyond alcohol, coffee, maté from the Pampas of Argentina, and whatever uppers
Worked_the_World
in
Advanced Prostate Cancer
2 months ago
Full body MRI?
We’ve been reading about full body MRIs and wonder if anyone has had one after radiation treatment for prostate cancer? Can this type of test pick up micro metastases? If the full body scan was “all clear” could ADT be shortened from 2 years to a lower amount?
We’ve been reading about full body MRIs and wonder if anyone has had one after radiation treatment for prostate cancer? Can this type of test pick up micro metastases? If the full body scan was “all clear” could ADT be shortened from 2 years to a lower amount?
Oatmeal2
in
Advanced Prostate Cancer
2 months ago
Zoladex and flu like symptoms
Hey. This may sound strange but does anyone suffer with flu like symptoms with the Zoladex? For the past 6 months I’ve had a number of ‘colds’ which seem to go straight to my sinuses but I have nothing else apart from feeling bunged up and absolutely no energy and achy. Just wondering if it could be
Hey. This may sound strange but does anyone suffer with flu like symptoms with the Zoladex? For the past 6 months I’ve had a number of ‘colds’ which seem to go straight to my sinuses but I have nothing else apart from feeling bunged up and absolutely no energy and achy. Just wondering if it could be
Louboo78
in
Endometriosis UK
2 months ago
B12 or Menopause?
In Dec I was diagnosed with B12 deficiency <148 and low folate <2.2. I had 6 loading doses into the beginning of January plus a month of folic acid and felt better quite quickly. Since then I have felt worse again so I had another blood test last week. My b12 is now 559 which is normal and folate is
In Dec I was diagnosed with B12 deficiency <148 and low folate <2.2. I had 6 loading doses into the beginning of January plus a month of folic acid and felt better quite quickly. Since then I have felt worse again so I had another blood test last week. My b12 is now 559 which is normal and folate is
UpsyDaisy2
in
Pernicious Anaemia Society
2 months ago
Ding Ding…Round Three.
I’m not sure if there is anyone out there that remembers me…or is prepared to admit it…but after a 12 month gap I am lacing up my shoes again. I graduated C25k six years ago and went on to graduate 10k aged 60 ish. I made some good friends on here and had great support. However a central ruke of my
I’m not sure if there is anyone out there that remembers me…or is prepared to admit it…but after a 12 month gap I am lacing up my shoes again. I graduated C25k six years ago and went on to graduate 10k aged 60 ish. I made some good friends on here and had great support. However a central ruke of my
Pm3eak
Graduate
in
Couch to 5K
2 months ago
Diagnosed almost 3 years ago
I am a 70 year old diagnosed in 8/21 with G9 on biopsy with initial imaging negative for metastatic disease. Underwent RP in 10/21 with seminal vesicle involvement. A few sampled nodes were negative. 5 months after surgery PSA climbed to 0.39 from 0.016 in first post op test. PSMA PET revealed a solitary
I am a 70 year old diagnosed in 8/21 with G9 on biopsy with initial imaging negative for metastatic disease. Underwent RP in 10/21 with seminal vesicle involvement. A few sampled nodes were negative. 5 months after surgery PSA climbed to 0.39 from 0.016 in first post op test. PSMA PET revealed a solitary
Retireddoc
in
Advanced Prostate Cancer
2 months ago
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