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Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
3 months ago
I’m Coco & today Joolsg suggested I post re upcoming NHS Iron Infusion
Hello RLS people I’ve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. You’ve helped me understand a lot…but am very aware there’s lots more to get my head around, so thanks for being here! now am about to have this IV
Hello RLS people I’ve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. You’ve helped me understand a lot…but am very aware there’s lots more to get my head around, so thanks for being here! now am about to have this IV
Barnclown
in
Restless Legs Syndrome
3 months ago
Adhd guidance
Hello everyone!! It has been 3 years since we started medication for my daughter who has adhd and we tried a lot of medications vyvanse, methylphenidate, guanfacine and the doctor was just increasing the dose but for her the first 2 weeks the medecine works and after that just stopped working. We went
Hello everyone!! It has been 3 years since we started medication for my daughter who has adhd and we tried a lot of medications vyvanse, methylphenidate, guanfacine and the doctor was just increasing the dose but for her the first 2 weeks the medecine works and after that just stopped working. We went
Purple008
in
CHADD's ADHD Parents Together
3 months ago
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Not PCa related, but interesting new delivery techniques:
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
Maxone73
in
Advanced Prostate Cancer
3 months ago
EMG and NCT tests query
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
Crochet_fan
in
Neuropathy Support
3 months ago
Group Therapy #3
Got a group meeting today and i'm nervous because I feel that people can pick up on my body language and read into it and notice, i'm nervous. Also afraid that I wont be able to stop observing the people around me and what they're doing and that will be noticed as well. I'd like some advice please.
Got a group meeting today and i'm nervous because I feel that people can pick up on my body language and read into it and notice, i'm nervous. Also afraid that I wont be able to stop observing the people around me and what they're doing and that will be noticed as well. I'd like some advice please.
EricJones
in
Anxiety and Depression Support
3 months ago
Any successful treatment with red light therapy for peripheral neuropathy?
Hello, I am wondering whether or not it’s worth pursuing some sort of photobiomodulation (red light) therapy as a way of addressing idiopathic peripheral neuropathy which, in my case, means numb feet with burning soles at night. Has anybody had any success with these types of intervention, either through
Hello, I am wondering whether or not it’s worth pursuing some sort of photobiomodulation (red light) therapy as a way of addressing idiopathic peripheral neuropathy which, in my case, means numb feet with burning soles at night. Has anybody had any success with these types of intervention, either through
1jay
in
Neuropathy Support
3 months ago
t3 Monotherapy
Hello everyone, I have been a reader of the forum for a while now and it is nice to know so many other people are struggling with un-resolved thyroid problems. This forum was the first place where I thought wow, these guys get it. I have hypermobile ehlers danlos syndrome, I was diagnosed with MS
Hello everyone, I have been a reader of the forum for a while now and it is nice to know so many other people are struggling with un-resolved thyroid problems. This forum was the first place where I thought wow, these guys get it. I have hypermobile ehlers danlos syndrome, I was diagnosed with MS
Jimjamio
in
Thyroid UK
3 months ago
help with results please
I’d be grateful if anyone could help with results please. I’m on combined therapy 50mg T4 and 35mg T3 TFT 0.02 (0.35-4.94) FT3 4.5 (2.4-6.00) FT4 8.1 (9.00-19.00) B12 433 (187-883) Vit D 126.1 >50 Thank you :)
I’d be grateful if anyone could help with results please. I’m on combined therapy 50mg T4 and 35mg T3 TFT 0.02 (0.35-4.94) FT3 4.5 (2.4-6.00) FT4 8.1 (9.00-19.00) B12 433 (187-883) Vit D 126.1 >50 Thank you :)
Bollieforme
in
Thyroid UK
3 months ago
Group Therapy #2
So i went to my second group therapy. It went well, know seemed to be paying much attention to my body language (like I'm afraid of) no one seemed to see me see them carrying on and being themselves. (hyper focusing on them). But the one thing I cant stop from happening is hearing background sounds such
So i went to my second group therapy. It went well, know seemed to be paying much attention to my body language (like I'm afraid of) no one seemed to see me see them carrying on and being themselves. (hyper focusing on them). But the one thing I cant stop from happening is hearing background sounds such
EricJones
in
Anxiety and Depression Support
3 months ago
Update on me
Before I go to visit Ralph this morning, thought I'd write a bit about me. I rang this morning to see how his first night was, he'd vomited a little which she said was due to the stress of the move, but then he was fine and slept well. Last night was the first decent sleep I've had since his operation
Before I go to visit Ralph this morning, thought I'd write a bit about me. I rang this morning to see how his first night was, he'd vomited a little which she said was due to the stress of the move, but then he was fine and slept well. Last night was the first decent sleep I've had since his operation
Hidden
in
British Heart Foundation
3 months ago
Tips for knee pain at 68
Hi everyone, I'm Lyndon. I Woke up Saturday morning with a horrible surprise - knee pain. It's centered on the front left side of my right knee, a dull ache that's been keeping me up at night and making it tough to move around. At 68, I've had my fair share of aches and pains, but this is new territory
Hi everyone, I'm Lyndon. I Woke up Saturday morning with a horrible surprise - knee pain. It's centered on the front left side of my right knee, a dull ache that's been keeping me up at night and making it tough to move around. At 68, I've had my fair share of aches and pains, but this is new territory
LyndonH
in
Pain Concern
3 months ago
INSURANCE DENIED - STAGE 4 BREAST CANCER
HI everyone, my mother is diagnosed with stage 4 breast cancer and doctor to give phesgo ( pertuzumab and transtuzumab) but insurance people told its a immunotheraphy so they wont apporve, but my oncologist told its a targeted therapy not immuno. my insurance is new india insurance under tpa being mediassist.Did
HI everyone, my mother is diagnosed with stage 4 breast cancer and doctor to give phesgo ( pertuzumab and transtuzumab) but insurance people told its a immunotheraphy so they wont apporve, but my oncologist told its a targeted therapy not immuno. my insurance is new india insurance under tpa being mediassist.Did
Srikalakm
in
Breast Cancer India
3 months ago
What a difference
Been a good day for him so far. He said he had a rough night coughing. He was in his chair dressed when I got there. Physio told him off and said you don't need the hoist now, use the pulley to get up and in the chair.Physio and speech therapist came to put tiny camera up his nose to look down his throat
Been a good day for him so far. He said he had a rough night coughing. He was in his chair dressed when I got there. Physio told him off and said you don't need the hoist now, use the pulley to get up and in the chair.Physio and speech therapist came to put tiny camera up his nose to look down his throat
Hidden
in
British Heart Foundation
4 months ago
Incontinence - A major problem
I have had Parkinson's since the spring of 2014. I had my first major fall (any fall that requires a trip to the ER) in Oct. of 2018, and I have gone downhill since that night. The Parkinson's symptom that's keeping me from leading a normal life is a freezing gait, although I do have overall tightness
I have had Parkinson's since the spring of 2014. I had my first major fall (any fall that requires a trip to the ER) in Oct. of 2018, and I have gone downhill since that night. The Parkinson's symptom that's keeping me from leading a normal life is a freezing gait, although I do have overall tightness
ZOOM4522
in
Cure Parkinson's
4 months ago
A question for anyone who built a red light therapy helmet/hat.
Hello. I’m interested in building a red light therapy hat. But I’m having trouble finding a source for 670nm and 810nm led strips. I was wondering if anyone who has built a hat using these specific wavelengths could share a link to where they purchased them. Thank you.
Hello. I’m interested in building a red light therapy hat. But I’m having trouble finding a source for 670nm and 810nm led strips. I was wondering if anyone who has built a hat using these specific wavelengths could share a link to where they purchased them. Thank you.
Glenfarclas
in
Cure Parkinson's
4 months ago
T4 and T3 split dosing
For those who are on T4 / T3 combination therapy, please can you share your regime and also what were your symptoms before and after splitting ?Thank you in advance.
For those who are on T4 / T3 combination therapy, please can you share your regime and also what were your symptoms before and after splitting ?Thank you in advance.
Lavender-Blue
in
Thyroid UK
4 months ago
Do you want to take part in research to help advance speech therapies for ataxias?
The University of Strathclyde and US company LSVT Global are recruiting for participants with Friedreich’s ataxia (FA) aged 18 or over to take part in an online one-to-one speech therapy study. The study will explore the use of a speech therapy treatment called LSVTArtic®, and the study will take place
The University of Strathclyde and US company LSVT Global are recruiting for participants with Friedreich’s ataxia (FA) aged 18 or over to take part in an online one-to-one speech therapy study. The study will explore the use of a speech therapy treatment called LSVTArtic®, and the study will take place
Irmmy
in
Ataxia UK
4 months ago
Ongoing battle to stay on T3
I have been on T3 only for over 15 years. This was prescribed by a GP and Endo in Essex. 12 years ago I moved to Sheffield then Derbyshire.I had been with my new surgery for 2 years when out of the blue they started getting cagey about giving me T3, At first it was lots of questions and scaremongering
I have been on T3 only for over 15 years. This was prescribed by a GP and Endo in Essex. 12 years ago I moved to Sheffield then Derbyshire.I had been with my new surgery for 2 years when out of the blue they started getting cagey about giving me T3, At first it was lots of questions and scaremongering
Freewoman1997
in
Thyroid UK
4 months ago
approachable private endo preferably south essex
hi there I am looking for recommendations for private endocrinologist who is understanding and open to trying t3/ combination therapy. I live in south Essex and am disabled so preferably local but willing to consider online or to travel a bit. Bonus if they are also an nhs endo. I have the list from
hi there I am looking for recommendations for private endocrinologist who is understanding and open to trying t3/ combination therapy. I live in south Essex and am disabled so preferably local but willing to consider online or to travel a bit. Bonus if they are also an nhs endo. I have the list from
TheaW
in
Thyroid UK
4 months ago
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