Biological therapy.

[pmrdec112014]

I have been reading through all the posts on biological therapy.I have literally this week just heard that I qualify for Tezspire.

The wait time is about 4 weeks.

I am wondering who else is having this / had it and how they are getting on .

Thank you.

[Mark-f]

been on them over ten years , In fact I was one of the first , I’ve been on three different ones

Xolair

Mepolizomab

And the the last 4 years Benralizumab, I self administer my own injections now and have done for around 3 years .. been very good and improved my symptoms massively!!

Good luck with it

[runcyclexcski in reply to Mark-f]

Mark, did you stop the first two because they'd stopped working?

[Mark-f in reply to runcyclexcski]

Yes .. it can take a while to find the rite one that suits

[Patk1 in reply to Mark-f]

How often do u do Yr benralizumab x

[Mark-f in reply to Patk1]

xolair and mepolizomab every 4 weeks , Benralizumab every 8 weeks but it definitely seems to loose some effectiveness after 6 weeks

[Patk1 in reply to Mark-f]

Thanx.yes I find it wears off,which isn't gd x

[Biggles2612]

I have been on Benralizumab for the last year and I find it to be amazing . No exacerbations and rarely use blue inhaler

[Mickeyboy2020]

hi, yes I’ve been on this drug for best part of a year now. I’ve been ok on it and I think it’s been good for me, few aches and pains but that could be old age/statins who knows , now 66. I’ve been on prednisalone now for more years than I can remember, doses ranging from 50 mg down to 30 mg daily. This drug has enabled me to reduce my daily dose of prednisalone down to 2 mg over a period of a year, also another benefit is that I hardly have to use my Blue salbutamol inhaler also don’t get so breathless as I used to and sometimes going weeks without needing it, I mainly have to use only when I have a chest infection of which I seem to be getting more of them than I would like, whether this is due to the tezapire I’m not sure, I think they are monitoring this

Hope this helps and works for you

I’ve been on all the biologics as they came out but they all stopped working after a while, this has been the best one yet in my eyes and you have the benefit of self administering at home.

Good luck

Mike

[pmrdec112014 in reply to Mickeyboy2020]

Thank you every one for your replies, particularly Mike's as he is currently on the Tezspire which I am specifically interested in.I don't have eosonaphillic asthma at all just ( I say just) infection based, which has literally taken over my life and completely floored me in the past two and half years since getting covid twice.

I have always had to have regular courses of steroids since diagnosis 31 years ago but the past year in particular I have had to have 6 courses of steroids, often for many weeks at a time.

Currently at my very very worse physically as well as emotionally.

A lot hinges on this drug which is the only biologic I can be approved for as far as I am aware.

[Jamesd1986]

Hi, I’m pleased to hear you will be elegible for this treatment . I am curious to know how you found the process to become eligible?

I am also going through the process to try and get this myself, but going through tests to ‘proove my asthma’ because my lung function tests came back positive . However, I am severely allergic to almost everything and am waking up coughing up phlegm and having asthma issues every night and every spring to autumn for 8 years. Recently had chest / sinus infections and 3 courses of steroids. I am due to have an allergy induced asthma test and an x ray next week to check my lungs and maybe had Covid in October as still over producing phlegm on my lungs. Really hoping I can get this biologic treatment too!

[pmrdec112014 in reply to Jamesd1986]

After regular repeated flares and infections and tons of steroids I was referred to the severe asthma clinic last June by my chest physican at my local hospital.I am on high dose combined inhaler ( have been changed to a few different ones over the past two or three years) as well as Spiriva Respirmat.

I was seen in the severe asthma clinic in Oct and then have been seen in the walk in clinic.

I am on long term steroids for another condition so they felt that the steroids were masking some of the inflammation.

However a ct scan showed lots of inflammation apparently consistent with small air ways disease and then in March when feeling ill again my FENO test was high and so the case was put to panel and approved.

I also hav chronic sinus problems of which I have had a few ops for.

[Jamesd1986 in reply to pmrdec112014]

Wow, that sounds very intense but I’m glad you have had the help and getting the treatment you need. Good luck with the biologics…. I also have lot of nasal problems although asthma maybe not as severe. I hope the injections help and thank you for explaining the process

[Mickeyboy2020]

hopefully it will sort you out, be positive. Just taken this months dose, they’ve given me a new type of pen to administer instead of a syringe. Lot less fuss. Wish you luck I’m sure you’ll be fine 👍🏻

[sciencepotato]

hi, I've just been approved too and will update you once I get my jab.

Hope it will work wonders for you!

[pmrdec112014 in reply to sciencepotato]

That's great news! It took exactly 1 month from date of approval to having 1st one so hopefully similar time frame for you if not sooner!

[sciencepotato in reply to pmrdec112014]

Brilliant! Pleased for you that no noticeable side effects - long may it continue and hope it'll be absolutely life changing in the best way possible.

No idea when the first jab will be yet - just had an appointment with the consultant this week to confirm I'll be getting tez.

Do you feel any different yet?

[pmrdec112014]

Just had my first injection yesterday at Guys! Shattered from the build up and the travelling but otherwise all good. No side effects to date!