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Yale develops new form of Immunotherapy...
Yale has developed a new form of immunotherapy that seeks out cancer cells and marks them for destruction using a combination of viral gene therapy and CRISPR gene editing technology. Should improve the ability of immunotherapy to seek out and destroy tumor cells,... https://www.sciencedaily.com/releases
Yale has developed a new form of immunotherapy that seeks out cancer cells and marks them for destruction using a combination of viral gene therapy and CRISPR gene editing technology. Should improve the ability of immunotherapy to seek out and destroy tumor cells,... https://www.sciencedaily.com/releases
NPfisherman
in
Fight Prostate Cancer
5 years ago
Nobel Prize - William Kaelin, Peter Ratcliffe, and Gregg Semenza.
I was interested to see this morning's news [1] because it has a bearing on a point I was recently trying to make (unsuccessfully). It's not uncommon to find someone on a cancer site claim that cancer hates oxygen. 'If only we could get more oxygen to the cancer it would die.' PCa is not at all inconvenienced
I was interested to see this morning's news [1] because it has a bearing on a point I was recently trying to make (unsuccessfully). It's not uncommon to find someone on a cancer site claim that cancer hates oxygen. 'If only we could get more oxygen to the cancer it would die.' PCa is not at all inconvenienced
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Circulating Tumor Cell Report; #1 of 2 from Tyme
Hello all, I've been lurking here for some time & am exceedlingly grateful to everyone who posts and keeps up the good fight. I have often wondered about tumor burden and circulating tumor cells, especially when it is characterized as "high" or "heavy" vs "low" or "light." Seems to me this is something
Hello all, I've been lurking here for some time & am exceedlingly grateful to everyone who posts and keeps up the good fight. I have often wondered about tumor burden and circulating tumor cells, especially when it is characterized as "high" or "heavy" vs "low" or "light." Seems to me this is something
mistersafety
in
Advanced Prostate Cancer
5 years ago
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Anyone else have chronic pain that has limited your ability to travel in a car or even leave the house for long period of time??
Question and long rant. I am struggling big time with chronic pain, mostly nerve pain but also ovary pain around ovulation and period weeks. I had my lap about 14 weeks ago that diagnosed and removed an extensive amount of endo and i have been on Visanne since then that has stopped my period bleeding
Question and long rant. I am struggling big time with chronic pain, mostly nerve pain but also ovary pain around ovulation and period weeks. I had my lap about 14 weeks ago that diagnosed and removed an extensive amount of endo and i have been on Visanne since then that has stopped my period bleeding
Lejay
in
Endometriosis UK
5 years ago
Phase 2 Trial of Gene Therapy, VY-AADC02, for Advanced Parkinson’s Enrolling in US
https://parkinsonsnewstoday.com/2019/09/24/phase-2-trial-vy-aadc02-gene-therapy-enrolling-advanced-parkinsons-at-us-sites/
https://parkinsonsnewstoday.com/2019/09/24/phase-2-trial-vy-aadc02-gene-therapy-enrolling-advanced-parkinsons-at-us-sites/
Farooqji
in
Cure Parkinson's
5 years ago
Meningoencephalitis Survivor
Hey everyone, I had Meningoencephalitis back in 2011, and have had a headache (usually a 5/10) everyday since (yup, 7 years worth). About once every two months i'll have a 'blow' out and have to go to hospital for stronger meds to bring the pain level back to 'my normal'. I have tried Sandomigran, Endep
Hey everyone, I had Meningoencephalitis back in 2011, and have had a headache (usually a 5/10) everyday since (yup, 7 years worth). About once every two months i'll have a 'blow' out and have to go to hospital for stronger meds to bring the pain level back to 'my normal'. I have tried Sandomigran, Endep
MeningoencephSur5ver
in
Meningitis Now
5 years ago
Voyager sails to deliver Parkinson’s Disease first functional gene-therapy controlling dyskinesia for up to 3 years
https://seekingalpha.com/article/4290520-voyager-therapeutics-alternative-read-parkinsons-asset-phase-1b-data
https://seekingalpha.com/article/4290520-voyager-therapeutics-alternative-read-parkinsons-asset-phase-1b-data
Farooqji
in
Cure Parkinson's
5 years ago
Newly diagnosed with Polymyalgia Rheumatica and more recently GCA
Hi everyone, I’m new here and have been reading lots of posts as I am in lots of pain and feeling pretty low. I have had Fibromyalgia since 2001 and have now been hit with another myalgia. Don’t know what I did to deserve this. Anyway, I am in my late 60s, usually pretty stoic and just get on with life
Hi everyone, I’m new here and have been reading lots of posts as I am in lots of pain and feeling pretty low. I have had Fibromyalgia since 2001 and have now been hit with another myalgia. Don’t know what I did to deserve this. Anyway, I am in my late 60s, usually pretty stoic and just get on with life
KrisAnne51
in
PMRGCAuk
5 years ago
A CANCER VACCINE….. At last visit my Doc mentioned a vaccine, but I didn’t inquire with him Further, then read this in Tampa Bay Times.
A vaccine, called ImmuneFx, makes cancer cells visible to the immune system. After successful trials on animals, it's being tested on humans. Times staff writer TAMPA - Tampa scientists Michael and Patricia Lawman imagine a day when cancer could be treated with a single needle prick and no debilitating
A vaccine, called ImmuneFx, makes cancer cells visible to the immune system. After successful trials on animals, it's being tested on humans. Times staff writer TAMPA - Tampa scientists Michael and Patricia Lawman imagine a day when cancer could be treated with a single needle prick and no debilitating
tekusa
in
CLL Support
5 years ago
Advances in drug‐based therapies in chronic lymphocytic leukemia and future prospects
First published: 08 February 2019 in Advances in Cell and Gene Therapy Journal Chronic lymphocytic leukemia (CLL) has experienced a revolution over the past few decades with a marked expansion in therapeutic options and improvement in outcomes. This success can be attributed to an improved understanding
First published: 08 February 2019 in Advances in Cell and Gene Therapy Journal Chronic lymphocytic leukemia (CLL) has experienced a revolution over the past few decades with a marked expansion in therapeutic options and improvement in outcomes. This success can be attributed to an improved understanding
Jm954
Administrator
in
CLL Support
5 years ago
Does anyone have any sleeping remedies or meds that work?
I was taking Endep (which gave me a full night's sleep) but my Neurologist changed me from Stalevo (which was giving me Dyskenesia) to Madopar + Xadago. But I had to cease the Endep as he said it could conflict with the Xadago, which is a fairly new drug that is still being trialled. He prescribed Paxam
I was taking Endep (which gave me a full night's sleep) but my Neurologist changed me from Stalevo (which was giving me Dyskenesia) to Madopar + Xadago. But I had to cease the Endep as he said it could conflict with the Xadago, which is a fairly new drug that is still being trialled. He prescribed Paxam
Hidden
in
Cure Parkinson's
5 years ago
Potential One-time Gene Therapy for Parkinson’s Linked to GBA Mutations to Enter Clinical Trial
A potential gene therapy for Parkinson’s disease associated with mutations in the GBA1 gene, PR001, will move into clinical testing in patients after the U.S. Food and Drug Administration (FDA) accepted an application for the therapy, Prevail Therapeutics announced https://parkinsonsnewstoday.com/2019
A potential gene therapy for Parkinson’s disease associated with mutations in the GBA1 gene, PR001, will move into clinical testing in patients after the U.S. Food and Drug Administration (FDA) accepted an application for the therapy, Prevail Therapeutics announced https://parkinsonsnewstoday.com/2019
Farooqji
in
Cure Parkinson's
5 years ago
Parkinson's: New gene therapy shows promise for prevention.
A new study hits on ground that PD can be found to treat using Gene therapy by targeting alpha-synuclein -the toxic aggregated protein which causes to disrupt Neuronal Circuit . " Our results showed that gene therapy using alpha-synuclein-targeting ASOs is a promising strategy for the control and
A new study hits on ground that PD can be found to treat using Gene therapy by targeting alpha-synuclein -the toxic aggregated protein which causes to disrupt Neuronal Circuit . " Our results showed that gene therapy using alpha-synuclein-targeting ASOs is a promising strategy for the control and
Abdiqani
in
Cure Parkinson's
5 years ago
Gene Therapy Candidate AXO-Lenti-PD Continues to Benefit Parkinson’s Patients in SUNRISE-PD Trial
A single dose of Axovant’s gene therapy candidate AXO-Lenti-PD continues to improve motor function and has been well-tolerated after six months in two patients with advanced Parkinson’s disease, according to early results of an ongoing Phase 1/2 clinical trial. https://parkinsonsnewstoday.com/2019/06
A single dose of Axovant’s gene therapy candidate AXO-Lenti-PD continues to improve motor function and has been well-tolerated after six months in two patients with advanced Parkinson’s disease, according to early results of an ongoing Phase 1/2 clinical trial. https://parkinsonsnewstoday.com/2019/06
Farooqji
in
Cure Parkinson's
5 years ago
Prevail Therapeutics Announces IND Active for Phase 1/2 Trial of its Gene Therapy PR001 to Treat Parkinson’s Disease Patients with GBA1 Muta
Prevail Therapeutics Inc. (Prevail), a gene therapy company developing AAV-based gene therapies for patients with neurodegenerative diseases, today announced the U.S. Food and Drug Administration (FDA) has accepted the Company’s Investigational New Drug (IND) application for its lead gene therapy program
Prevail Therapeutics Inc. (Prevail), a gene therapy company developing AAV-based gene therapies for patients with neurodegenerative diseases, today announced the U.S. Food and Drug Administration (FDA) has accepted the Company’s Investigational New Drug (IND) application for its lead gene therapy program
Farooqji
in
Cure Parkinson's
5 years ago
Trial of magnetic resonance–guided putaminal gene therapy for advanced Parkinson's disease
Results Adeno‐associated virus, serotype‐2 vector carrying glial cell line‐derived neurotrophic factor was tolerated without clinical or radiographic toxicity. Average putaminal coverage was 26%. UPDRS scores remained stable. Ten of thirteen and 12 of 13 patients had increased [18F]FDOPA Kis at 6 and
Results Adeno‐associated virus, serotype‐2 vector carrying glial cell line‐derived neurotrophic factor was tolerated without clinical or radiographic toxicity. Average putaminal coverage was 26%. UPDRS scores remained stable. Ten of thirteen and 12 of 13 patients had increased [18F]FDOPA Kis at 6 and
Farooqji
in
Cure Parkinson's
5 years ago
Gene therapy marches on.
Boys and girls, have a bang on this - $2.1m Novartis gene therapy to become world's most expensive drug https://www.theguardian.com/science/2019/may/25/21m-novartis-gene-therapy-to-become-worlds-most-expensive-drug? Swiss drugmaker Novartis has received US approval for its spinal muscular atrophy
Boys and girls, have a bang on this - $2.1m Novartis gene therapy to become world's most expensive drug https://www.theguardian.com/science/2019/may/25/21m-novartis-gene-therapy-to-become-worlds-most-expensive-drug? Swiss drugmaker Novartis has received US approval for its spinal muscular atrophy
monkeybus
in
AMN EASIER
5 years ago
How did I miss this?? A real CURE for some genetic SCAs may be close!!!
By close I mean within a decade. Especially if you have SCA3 which is already in the pipeline for treatment. First the cliff notes version: A company in the Netherlands is moving towards a human clinical trial of a technology that could actually CURE many genetic SCAs with a one time injection into
By close I mean within a decade. Especially if you have SCA3 which is already in the pipeline for treatment. First the cliff notes version: A company in the Netherlands is moving towards a human clinical trial of a technology that could actually CURE many genetic SCAs with a one time injection into
sunvox
in
Ataxia UK
5 years ago
Life, diagnosis, drugs.... a bit of my life!
*long story sorry* After 10 years of severe pain and being told it was in my head... a lap finally diagnosed endo. After op, pain never totally went but improved, however this was only for a couple of months then it began building up again. Within 6 months it was back to it's usual full force. The gynae
*long story sorry* After 10 years of severe pain and being told it was in my head... a lap finally diagnosed endo. After op, pain never totally went but improved, however this was only for a couple of months then it began building up again. Within 6 months it was back to it's usual full force. The gynae
Butterflyblubum
in
Endometriosis UK
5 years ago
GP advised give up on anti depressant/anxiety medication ?
so I’ve tried setraline, pristiq, endep and now mirtazipine. all for at least 3 months each at the highest dose with no effect, most recently today I went into refill my mirtazipine which I take 60mg at night, and after telling doc I notice no difference in my depression/anxiety he suggests I continue
so I’ve tried setraline, pristiq, endep and now mirtazipine. all for at least 3 months each at the highest dose with no effect, most recently today I went into refill my mirtazipine which I take 60mg at night, and after telling doc I notice no difference in my depression/anxiety he suggests I continue
anxietypanic
in
Mental Health Support
5 years ago
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