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terrible metalic taste in my mouth ALL the time!
I’m now into my second year of PMR, I’m on 5mgs of Prednisone and 20mgs of somac a day, 50mgs of Endep at night. I don’t think I have changed anything in my diet etc but I have a terrible metallic taste in my mouth constantly, nothing cuts through it, I’ve tried biting a lime and nothing, whatever
I’m now into my second year of PMR, I’m on 5mgs of Prednisone and 20mgs of somac a day, 50mgs of Endep at night. I don’t think I have changed anything in my diet etc but I have a terrible metallic taste in my mouth constantly, nothing cuts through it, I’ve tried biting a lime and nothing, whatever
Heidiypi1
in
PMRGCAuk
8 months ago
Atorvastatin
I had been resisting my GPs' calls to take statins for some years having pointed out to them that although they were saying a total cholesterol level around 6 was too high the ratio of HDL to LDL was good. About eighteen months ago I acquiesceded and started taking Atorvastatin. However, l was hospitalised
I had been resisting my GPs' calls to take statins for some years having pointed out to them that although they were saying a total cholesterol level around 6 was too high the ratio of HDL to LDL was good. About eighteen months ago I acquiesceded and started taking Atorvastatin. However, l was hospitalised
Hidden
in
British Heart Foundation
1 year ago
A Webinair discussing the potential of Gene Therapy as treatment for Ataxia.
🙂 UK TIME…..7.30PM Join NAF on August 22nd at 1:30 pm CDT for our webinar on Gene Therapy. In this session, Dr. Carolyn Yrigollen will teach us what gene therapy is, the different types of gene therapy, and how gene therapy could be used to treat Ataxia in the future. We will also discuss the limitations
🙂 UK TIME…..7.30PM Join NAF on August 22nd at 1:30 pm CDT for our webinar on Gene Therapy. In this session, Dr. Carolyn Yrigollen will teach us what gene therapy is, the different types of gene therapy, and how gene therapy could be used to treat Ataxia in the future. We will also discuss the limitations
wobblybee
in
Ataxia UK
4 days ago
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What is gene therapy and can it help people with Parkinson’s?
https://www.apdaparkinson.org/article/gene-therapy-for-parkinsons-disease-3/
https://www.apdaparkinson.org/article/gene-therapy-for-parkinsons-disease-3/
Farooqji
in
Cure Parkinson's
1 month ago
Klotho gene therapy
https://parkinsonsnewstoday.com/news/anew-medical-advance-development-klotho-gene-therapy/?utm_source=PAR&utm_campaign=c732d6332f-Email_ENL_US_PAR&utm_medium=email&utm_term=0_62dd4fb5e3-c732d6332f-74556474 I have been trying to find out what is used to prepare Klotho gene therapy a therapy that supposedly
https://parkinsonsnewstoday.com/news/anew-medical-advance-development-klotho-gene-therapy/?utm_source=PAR&utm_campaign=c732d6332f-Email_ENL_US_PAR&utm_medium=email&utm_term=0_62dd4fb5e3-c732d6332f-74556474 I have been trying to find out what is used to prepare Klotho gene therapy a therapy that supposedly
Boscoejean
in
Cure Parkinson's
1 month ago
Not dying was a good plan, but how to navigate the future is the next challenge
I appreciate that I have achieved remission with my cancer and I was thinking about the fact that my liver, even though I have cirrhosis, managed all of the chemo drugs I've had pretty successfully. In our patient groups we often see people who die quickly when a second problem appears. As a vote
I appreciate that I have achieved remission with my cancer and I was thinking about the fact that my liver, even though I have cirrhosis, managed all of the chemo drugs I've had pretty successfully. In our patient groups we often see people who die quickly when a second problem appears. As a vote
nash2
Partner
in
Living with Fatty Liver and NASH
1 month ago
New Clinical Trial Starting: A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD) (REGENERATE-PD)
Here is a link to the trial on clinicaltrials.gov https://clinicaltrials.gov/study/NCT06285643?term=REGENERATE-PD&rank=1 Below is an excerpt from a news article about the trial: A new Phase II trial, REGENERATE-PD, will study AB-1005, an adeno-associated virus 2 (AAV2) glial cell line-derived neurotrophic
Here is a link to the trial on clinicaltrials.gov https://clinicaltrials.gov/study/NCT06285643?term=REGENERATE-PD&rank=1 Below is an excerpt from a news article about the trial: A new Phase II trial, REGENERATE-PD, will study AB-1005, an adeno-associated virus 2 (AAV2) glial cell line-derived neurotrophic
Canddy
in
Cure Parkinson's
2 months ago
Advice
Hi All, I have hearing loss in both ears and have tinnitus all the time. This is a difficult challenge for us all. The doctors just put you on betahistine or amitriptyline or alprazolam or any anti depressants they say it helps reduce tinnitus or improve blood flow to inner ear. This is the same
Hi All, I have hearing loss in both ears and have tinnitus all the time. This is a difficult challenge for us all. The doctors just put you on betahistine or amitriptyline or alprazolam or any anti depressants they say it helps reduce tinnitus or improve blood flow to inner ear. This is the same
CMRN11
in
Tinnitus UK
2 months ago
First gene therapy for prevalent pathologies in neurology receives FDA IND clearance - EG 427 initiating first-in-human clinical study
https://uk.finance.yahoo.com/news/first-gene-therapy-prevalent-pathologies-060000901.html
https://uk.finance.yahoo.com/news/first-gene-therapy-prevalent-pathologies-060000901.html
Farooqji
in
Cure Parkinson's
2 months ago
Aspen Neuroscience to Present at International Society for Cell & Gene Therapy (ISCT) Annual Meeting
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
Farooqji
in
Cure Parkinson's
3 months ago
Gene therapy
I know it's not PD but it is a neurological condition and sounds like a hopeful developmentUK toddler has hearing restored in world first gene therapy trial https://www.theguardian.com/science/article/2024/may/09/uk-toddler-has-hearing-restored-in-world-first-gene-therapy-trial?CMP=share_btn_url
I know it's not PD but it is a neurological condition and sounds like a hopeful developmentUK toddler has hearing restored in world first gene therapy trial https://www.theguardian.com/science/article/2024/may/09/uk-toddler-has-hearing-restored-in-world-first-gene-therapy-trial?CMP=share_btn_url
WinnieThePoo
in
Cure Parkinson's
3 months ago
Bayer and AskBio report data from Parkinson’s disease therapy trial
The bilateral infusions of AB-1005 were well tolerated, without any SAEs linked to the gene therapy or contrast agent. AskBio Parkinson’s and MSA Scientific chair Krystof Bankiewicz said: “These early findings are encouraging and show AB-1005 to be well tolerated in this study in patients with mild
The bilateral infusions of AB-1005 were well tolerated, without any SAEs linked to the gene therapy or contrast agent. AskBio Parkinson’s and MSA Scientific chair Krystof Bankiewicz said: “These early findings are encouraging and show AB-1005 to be well tolerated in this study in patients with mild
Farooqji
in
Cure Parkinson's
4 months ago
CRISPR 13 (what? you thought I abandoned CRISPR?): very promising proof of concept - Targeting HOXB13 in mPCa by CRISPR/Cas13d- nanoparticle
And people thought it was undruggable....they have already filed for a patent 😲 Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
And people thought it was undruggable....they have already filed for a patent 😲 Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
Maxone73
in
Advanced Prostate Cancer
4 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
5 months ago
Swanbio gene therapy study
Anyone know how this study is going? I did a google search and there was something posted a few days ago but you had to buy the report. $500. I’m very interested but information seems hard to come by. It doesn’t sound like it would repair damage but stop or slow the disease. I wonder if it would eliminate
Anyone know how this study is going? I did a google search and there was something posted a few days ago but you had to buy the report. $500. I’m very interested but information seems hard to come by. It doesn’t sound like it would repair damage but stop or slow the disease. I wonder if it would eliminate
Golfdog3
in
AMN EASIER
6 months ago
Gene therapy
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
TOP TAKEAWAYSGene therapy has a potential place In the treatment • of Parkinson disease, but won't be the "be all end al as some may think. There are a lot of questions regarding drug development of PD gene therapies, Including which targets are the most promlslng/effectlve. Investlgatlonal right now
Farooqji
in
Cure Parkinson's
6 months ago
Let's enjoy some predictions: cell and gene therapy in 2024
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
because sometimes we must also have some positive but realistic dreams.... https://www.massgeneralbrigham.org/en/about/newsroom/articles/2024-predictions-about-gene-and-cell-therapy
Maxone73
in
Advanced Prostate Cancer
7 months ago
Secondary Cancers after CAR-T Cell Therapy
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
From New England Journal of Medicine dated 24th Jan 2024 (article is for subscribers only) This brief report states: [i]The demonstrated efficacy of the current generation of approved CAR-T products comes along with several well-described safety concerns, including risks of cytokine release syndrome
Jm954
Administrator
in
CLL Support
7 months ago
Neurological Disorders: How Regenerative Medicines Help in Treating Nervous System Diseases
In this insightful discussion, the revolutionary field of regenerative medicine and its profound impact on treating neurological disorders are being discussed. Discover cutting-edge techniques such as stem cell therapy, gene therapy, and surgical innovations that are reshaping the landscape of neurology
In this insightful discussion, the revolutionary field of regenerative medicine and its profound impact on treating neurological disorders are being discussed. Discover cutting-edge techniques such as stem cell therapy, gene therapy, and surgical innovations that are reshaping the landscape of neurology
Farooqji
in
Cure Parkinson's
7 months ago
AB-1005
By posting this I am not necessarily advocating this treatment just trying to find out more information on how it is made and how it is administered [u]Gene therapy AB-1005 found safe in Phase 1b Parkinson’s trial[/u] https://parkinsonsnewstoday.com/news/gene-therapy-ab-1005-safe-phase-1b-trial/?utm_source
By posting this I am not necessarily advocating this treatment just trying to find out more information on how it is made and how it is administered [u]Gene therapy AB-1005 found safe in Phase 1b Parkinson’s trial[/u] https://parkinsonsnewstoday.com/news/gene-therapy-ab-1005-safe-phase-1b-trial/?utm_source
Boscoejean
in
Cure Parkinson's
8 months ago
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