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A case to push for darolutamide.
out of 68 known Variants that escaped treatment darolutamide is effective against all but one. This article is from june 2021. it is a invitro study so it needs vitro study, then insilico AI to further confirm but it is still important. And even shows resistant variants to abiraterone, corticosteroids
out of 68 known Variants that escaped treatment darolutamide is effective against all but one. This article is from june 2021. it is a invitro study so it needs vitro study, then insilico AI to further confirm but it is still important. And even shows resistant variants to abiraterone, corticosteroids
KocoPr
in
Advanced Prostate Cancer
2 years ago
Help with labs-Doctor says looks good, but I feel so tired.
I take 50mg Levo and 20mcg Cytomel daily also on Cymbalta for Neuropathy pain. TSH 0.306 FSH 46.2 T4 FREE 0.73 T4 5.0 T3 FREE 2.8 DHEA 153 CORTISOL 10.7 B12 431 VIT D 85.4 PROLACTIN 11.2 TESTOSTERONE 223 ESTRADIOL 52.5 PROGESTERONE 1.3
I take 50mg Levo and 20mcg Cytomel daily also on Cymbalta for Neuropathy pain. TSH 0.306 FSH 46.2 T4 FREE 0.73 T4 5.0 T3 FREE 2.8 DHEA 153 CORTISOL 10.7 B12 431 VIT D 85.4 PROLACTIN 11.2 TESTOSTERONE 223 ESTRADIOL 52.5 PROGESTERONE 1.3
Shelly55
in
Thyroid UK
2 years ago
My 51 Month tE2 (transdermal estradiol) Results
Just received my recent blood test results and needless to say that I'm thrilled with the numbers! Still, the ONLY side effect is some degree of gynecomastia which isn't a big deal since I'm still able to do my gym routine five nights/week plus doing 4 sets of 18 rep pull-ups (2 with hands facing forward
Just received my recent blood test results and needless to say that I'm thrilled with the numbers! Still, the ONLY side effect is some degree of gynecomastia which isn't a big deal since I'm still able to do my gym routine five nights/week plus doing 4 sets of 18 rep pull-ups (2 with hands facing forward
E2-Guy
in
Advanced Prostate Cancer
2 years ago
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HRT usage
Hi I am 57 and have just changed from HRT patches to100mg progesterone and estradiol gel , the tablets recommend take on an empty stomach at night should I use the gel at the same time as I had planned to use the gel after my morning shower ?
Hi I am 57 and have just changed from HRT patches to100mg progesterone and estradiol gel , the tablets recommend take on an empty stomach at night should I use the gel at the same time as I had planned to use the gel after my morning shower ?
Tiger227
in
Women's Health
2 years ago
When to stop Estradiol patches
When did you stop your estradiol patches in the run up to stimulation? Was it as soon as your period arrived (ie first spots of blood) or only when it hit full flow? Thanks so much!
When did you stop your estradiol patches in the run up to stimulation? Was it as soon as your period arrived (ie first spots of blood) or only when it hit full flow? Thanks so much!
Koala365
in
Fertility Network UK
2 years ago
Estrogen Dose Too High?
My hormones history is very long, so I won'tgo into great detail , but I had a hysterectomy (everything gone) about 16 years ago. I did fine on 1 mg oral estradiol for about 8 years. About 8 years later, I crashed badly with every menopausal symptom. The worse being the psychological ones. Not one
My hormones history is very long, so I won'tgo into great detail , but I had a hysterectomy (everything gone) about 16 years ago. I did fine on 1 mg oral estradiol for about 8 years. About 8 years later, I crashed badly with every menopausal symptom. The worse being the psychological ones. Not one
HeartWoman
in
Healthy Happy Woman
2 years ago
Latest Numbers
For those who have followed my remarkable 18 year journey with metastatic prostate cancer, new numbers are: PSA, Total, 0.05 Testosterone, Free, 78.1 Testosterone, Total, MS, 1467 Estradiol, 62 Major benefit, by optimizing and balancing hormones, I have shed almost 60 pounds of visceral fat in six
For those who have followed my remarkable 18 year journey with metastatic prostate cancer, new numbers are: PSA, Total, 0.05 Testosterone, Free, 78.1 Testosterone, Total, MS, 1467 Estradiol, 62 Major benefit, by optimizing and balancing hormones, I have shed almost 60 pounds of visceral fat in six
Hidden
in
Advanced Prostate Cancer
2 years ago
Lastest bloods
Recent results can I please have some help. I have Graves and Hyperthyroid.I also think I'm menopausal as getting really bad hot flushes ,joint pain and little sleep. Serum ferritin 52 ug/l (15-300.00ug/l) Serum folate >23.4ug/l(>3.00ug/l) Serum vit B12 246ng/l(130.00-900.00 HbA1c level 42mmol
Recent results can I please have some help. I have Graves and Hyperthyroid.I also think I'm menopausal as getting really bad hot flushes ,joint pain and little sleep. Serum ferritin 52 ug/l (15-300.00ug/l) Serum folate >23.4ug/l(>3.00ug/l) Serum vit B12 246ng/l(130.00-900.00 HbA1c level 42mmol
beesting1966
in
Graves Disease Support
2 years ago
Lastest bloods
Recent results can I please have some help. I have Graves and Hyperthyroid.I also think I'm menopausal as getting really bad hot flushes ,joint pain and little sleep. Serum ferritin 52 ug/l (15-300.00ug/l) Serum folate >23.4ug/l(>3.00ug/l) Serum vit B12 246ng/l(130.00-900.00 HbA1c level 42mmol
Recent results can I please have some help. I have Graves and Hyperthyroid.I also think I'm menopausal as getting really bad hot flushes ,joint pain and little sleep. Serum ferritin 52 ug/l (15-300.00ug/l) Serum folate >23.4ug/l(>3.00ug/l) Serum vit B12 246ng/l(130.00-900.00 HbA1c level 42mmol
beesting1966
in
Thyroid UK
2 years ago
DE failure
Our 5 th rounds has failed used DE this time. I don't know where to turn now. What else can I try. I was on on 12 mg oestradiol 120mg Utrogestan and prontogest every 72 hours. Inhixa. Used the results from ERA treated the bacterial infection my womb had from the EMMA result. What else is there I can
Our 5 th rounds has failed used DE this time. I don't know where to turn now. What else can I try. I was on on 12 mg oestradiol 120mg Utrogestan and prontogest every 72 hours. Inhixa. Used the results from ERA treated the bacterial infection my womb had from the EMMA result. What else is there I can
Conceivingblee
in
Fertility Network UK
2 years ago
huge difference in blood pressure readings in 30 munitues
I am now 58 years old female. Two years ago after my eldest son unexpectedly passed away my blood pressure drastically went up from my normal 129/90 to somewhere between 203/113 and 160/100 for about four months. I went on Lercanidipine 20mg once a day (also Estradiol HRT). In less than 6 months, I
I am now 58 years old female. Two years ago after my eldest son unexpectedly passed away my blood pressure drastically went up from my normal 129/90 to somewhere between 203/113 and 160/100 for about four months. I went on Lercanidipine 20mg once a day (also Estradiol HRT). In less than 6 months, I
kpeters001
in
High Blood Pressure Support
2 years ago
6dp5dt donor egg FET
Hi Guys this is the first ever FET I've done my other 4 cycles were all fresh transfers. I'm on super high levels of oestradiol 12mg a day prontogest every 72 hours and Utrogestan 6 x 200 a day. I've had boob pain and really heavy womb since pre transfer. Had transfer on 29th we bought 6 eggs 5 didn't
Hi Guys this is the first ever FET I've done my other 4 cycles were all fresh transfers. I'm on super high levels of oestradiol 12mg a day prontogest every 72 hours and Utrogestan 6 x 200 a day. I've had boob pain and really heavy womb since pre transfer. Had transfer on 29th we bought 6 eggs 5 didn't
Conceivingblee
in
Fertility Network UK
2 years ago
Oestriol and Lupus
I am 71 and have had recurrent UTIs. My GP has prescribed me Oestriol cream and told to use it daily, on my genitals, to help with the post-menopausal atrophy of the general area but particularly around my urethral opening. With oestriol I do not need progesterone. The leaflet in the box
I am 71 and have had recurrent UTIs. My GP has prescribed me Oestriol cream and told to use it daily, on my genitals, to help with the post-menopausal atrophy of the general area but particularly around my urethral opening. With oestriol I do not need progesterone. The leaflet in the box
skylark15
in
LUPUS UK
2 years ago
Oestradiol patches day 15 or 16?
Has anyone done a protocol where they started using oestradiol 100mcg patches part way through their cycle then started stimulation injections at their next period? My protocol says to start the patches on Day 15 or Day 16. At one point on the phone the nurse definitely said in passing start on Day 15
Has anyone done a protocol where they started using oestradiol 100mcg patches part way through their cycle then started stimulation injections at their next period? My protocol says to start the patches on Day 15 or Day 16. At one point on the phone the nurse definitely said in passing start on Day 15
Koala365
in
Fertility Network UK
2 years ago
Free T levels dropped since being on HRT - Oestradiol patches
I’m very confused !!! I had my thyroid levels tested along with Oestradiol as my feet are swollen. Skin feels tight on lower legs too. Weight gain. Constipation - having to use Fybogel every day now. I’ve been on oestrogen only hrt since august of last year . Firstly the gel that you rub in. Then because
I’m very confused !!! I had my thyroid levels tested along with Oestradiol as my feet are swollen. Skin feels tight on lower legs too. Weight gain. Constipation - having to use Fybogel every day now. I’ve been on oestrogen only hrt since august of last year . Firstly the gel that you rub in. Then because
130396
in
Thyroid UK
2 years ago
Feeling so tired and absolutely drained
Good afternoon, l wonder whether anyone would be kind enough please to see if they can help me? I have been feeling very tired and drained for several months and I am not sure if it might also have been aggravated by Covid, which I had in March this year. I have had a series of private blood tests,
Good afternoon, l wonder whether anyone would be kind enough please to see if they can help me? I have been feeling very tired and drained for several months and I am not sure if it might also have been aggravated by Covid, which I had in March this year. I have had a series of private blood tests,
sadiethedog1
in
Thyroid UK
2 years ago
Weight Gain with IVF meds (FET)
Hi everyone, I started my first round of IVF back in March, I had a BMI of 29 so only just within the NHS requirements, and was told ideally to lose weight if possible. I seemed fine with the drugs for egg collection, obvious hormonal fluctuations and a few aches/tiredness, but nothing weight gain related
Hi everyone, I started my first round of IVF back in March, I had a BMI of 29 so only just within the NHS requirements, and was told ideally to lose weight if possible. I seemed fine with the drugs for egg collection, obvious hormonal fluctuations and a few aches/tiredness, but nothing weight gain related
IVFtrip
in
Fertility Network UK
2 years ago
Falsely elevated serum estradiol in woman of reproductive age led to unnecessary intervention and delayed fertility opportunity
On this forum, we have become familiar with the occurrence of interference with laboratory tests. Probably the most discussed in recent times ahs been that of biotin on tests which use streptin-avidin. Although the interference reported is not directly thyroid, sex hormones are very frequently discussed
On this forum, we have become familiar with the occurrence of interference with laboratory tests. Probably the most discussed in recent times ahs been that of biotin on tests which use streptin-avidin. Although the interference reported is not directly thyroid, sex hormones are very frequently discussed
helvella
Thyroid UK
in
Thyroid UK
2 years ago
Estradiol Clinical Trial in UK?
Since my diagnosis of hormone-resistant and metastatic, I've been researching my options, beyond SOC (my onco wants me to start enzalutamide + Leuprorolin immediately) . Having seen E2-Guy post on Estradiol, I saw that there is a clinical trial taking place in the UK, so I am interested in joining
Since my diagnosis of hormone-resistant and metastatic, I've been researching my options, beyond SOC (my onco wants me to start enzalutamide + Leuprorolin immediately) . Having seen E2-Guy post on Estradiol, I saw that there is a clinical trial taking place in the UK, so I am interested in joining
CrocodileShoes
in
Advanced Prostate Cancer
2 years ago
Treatment after RP with affected lymph nodes
Hello! This is my first post to this forum, which I am following from some time ago, since I have some doubts about next steps of treatment of my advanced PC and would appreciate very much your help, in order to take best grounded decisions. My basic history on this matter is: • 2016: 58 years. PSA
Hello! This is my first post to this forum, which I am following from some time ago, since I have some doubts about next steps of treatment of my advanced PC and would appreciate very much your help, in order to take best grounded decisions. My basic history on this matter is: • 2016: 58 years. PSA
Urogallo
in
Advanced Prostate Cancer
2 years ago
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