Since my diagnosis of hormone-resistant and metastatic, I've been researching my options, beyond SOC (my onco wants me to start enzalutamide + Leuprorolin immediately) . Having seen ronronHU post on Estradiol, I saw that there is a clinical trial taking place in the UK, so I am interested in joining it. Viewing zoom calls of Dr Richard Wassersug, he seems to have had extraordinary success with transdermal gel. If anyone here has either used it as a monotherapy (or in combo) or if anyone has done research on it, I'd be grateful for any light you can shed on the following:
1. Does it follow the usual path of second-line treatments (i.e. resistance sets in after a couple of years?
2. Is it even suitable for me, since Bicalutamide has failed?
3. If I had another Prostap injection (due in August) would that disqualify me from a clinical trial?
4. Is there even such a thing as castrate resistance if - according to my onco - my psa will fall with enzalutamide + Prostap? Isn't it more accurate to say that you just need increasingly stronger dosage? And why do we continue with Leuprorolin when hormone resistance has kicked in?
I'd be especially interested in any personal testimonies with Transdermal get or indeed any other non-SOC routes that you have tried. I know that I'm not in any immediate danger of 'popping my clogs' (US warriors may need to Google that) But it still seems to be a one-way road to a cul-de-sac.....