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Augmentation
Hi, I am trying to come off the
dopamine
agonist that I have been taking for the past eight years for my RLS, does anybody know if the augmentation I have built up will go when I am clear of the medication, or am I stuck with it for the rest of my life?
Hi, I am trying to come off the
dopamine
agonist that I have been taking for the past eight years for my RLS, does anybody know if the augmentation I have built up will go when I am clear of the medication, or am I stuck with it for the rest of my life?
Mounta
in
Restless Legs Syndrome
1 year ago
blood test back - any thoughts?
Also my white blood count came back as much lower (3.6 vs 5 last year) - do any
dopamine
or prefab affect blood results? Just curious about the drop. Thanks as always for all your support in getting this far.
Also my white blood count came back as much lower (3.6 vs 5 last year) - do any
dopamine
or prefab affect blood results? Just curious about the drop. Thanks as always for all your support in getting this far.
Phantom38
in
Restless Legs Syndrome
11 months ago
Mitochondrial failing due to T3 problems
I have also read that - • Prolonged administration of pharmacological doses of
dopamine
can significantly reduce serum TSH levels and thyroid hormone secretion in normal and critically ill subjects. I have been taking
dopamine
agonists for years.
I have also read that - • Prolonged administration of pharmacological doses of
dopamine
can significantly reduce serum TSH levels and thyroid hormone secretion in normal and critically ill subjects. I have been taking
dopamine
agonists for years.
Simonron
in
Thyroid UK
11 months ago
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1st transplant done in trial of Parkinson’s cell therapy ANPD001
This experimental therapy for Parkinson’s uses a type of stem cell called an induced pluripotent stem cell, or iPSC, which is able to generate nearly any type of cell in the body — including
dopamine
-producing neurons. Its manufacturing is a three-step process.
This experimental therapy for Parkinson’s uses a type of stem cell called an induced pluripotent stem cell, or iPSC, which is able to generate nearly any type of cell in the body — including
dopamine
-producing neurons. Its manufacturing is a three-step process.
Farooqji
in
Cure Parkinson's
14 days ago
Reducing Augmentation
https://sleepreviewmag.com/sleep-disorders/movement-disorders/restless-legs-syndrome/reduce-augmentation-risk-restless-legs-syndrome/ A useful article on
Dopamine
Agonists and augmentation by Dr William Ondo.
https://sleepreviewmag.com/sleep-disorders/movement-disorders/restless-legs-syndrome/reduce-augmentation-risk-restless-legs-syndrome/ A useful article on
Dopamine
Agonists and augmentation by Dr William Ondo.
Joolsg
in
Restless Legs Syndrome
1 year ago
Why I pay no attention to studies of PD in mice.
Perhaps the current rodent models of PD would be more predictive of what will translate into human studies if the time course of
dopamine
neuron degeneration could be mimicked and behavioral tests were designed to assess the more subtle symptoms ... ” “… Perhaps one of the most relevant examples … with
Perhaps the current rodent models of PD would be more predictive of what will translate into human studies if the time course of
dopamine
neuron degeneration could be mimicked and behavioral tests were designed to assess the more subtle symptoms ... ” “… Perhaps one of the most relevant examples … with
MBAnderson
in
Cure Parkinson's
9 months ago
Could Psychedelics help in Parkinsons Disease treatment?
- Symptom management - Some research indicates psychedelics may protect
dopamine
neurons or stimulate growth of new ones. Reopening plasticity periods could enhance this through combined psychedelic and neurostimulation therapies.
- Symptom management - Some research indicates psychedelics may protect
dopamine
neurons or stimulate growth of new ones. Reopening plasticity periods could enhance this through combined psychedelic and neurostimulation therapies.
pdpatient
in
Cure Parkinson's
9 months ago
Dopamine a key factor in whether people find exercise easy or hard
https://www.diabetes.co.uk/news/2023/apr/
dopamine
-a-key-factor-in-whether-people-find-exercise-easy-or-hard.html
https://www.diabetes.co.uk/news/2023/apr/
dopamine
-a-key-factor-in-whether-people-find-exercise-easy-or-hard.html
Farooqji
in
Cure Parkinson's
1 year ago
Phenylethylamine is NOT Palmitoylethanolamide! They are both called PEA. I take Palmitoylethanolamide
Another signifi cant observation is that administration of β-PEA to rodents reduces striatal
dopamine
content and induces movement disorders similar to those of parkinsonian rodents. However, no reports are available on the extent of dopaminergic neuronal cell death after administration of β-PEA.
Another signifi cant observation is that administration of β-PEA to rodents reduces striatal
dopamine
content and induces movement disorders similar to those of parkinsonian rodents. However, no reports are available on the extent of dopaminergic neuronal cell death after administration of β-PEA.
Bolt_Upright
in
Cure Parkinson's
9 months ago
mucuna pruriens for people without Parkinson’s?
He has however still suffered with motivation and procrastination which after watching a video by dr Andrew Huberman I put down to low
dopamine
.
He has however still suffered with motivation and procrastination which after watching a video by dr Andrew Huberman I put down to low
dopamine
.
LAJ12345
in
Cure Parkinson's
10 months ago
Rytary
1 -25/100 and 145 mg Rytary helps with off time when I run out of
dopamine
, I have to sit down and wait for pills to kick in, but the Rytary helps with that now, but I’m very stiff and achy in leg and arm since on Rytary, anyone else experiencing stiffness with Rytary?
1 -25/100 and 145 mg Rytary helps with off time when I run out of
dopamine
, I have to sit down and wait for pills to kick in, but the Rytary helps with that now, but I’m very stiff and achy in leg and arm since on Rytary, anyone else experiencing stiffness with Rytary?
akgirlsrock
in
Cure Parkinson's
1 year ago
The environment makes the cells says Bruce Lipton. The importance of isolating the supposedly sick person...
established by a process of assigning transgenerational information (mechanics unknown to science) whose trauma is originally It spreads among members of future generations, causing intense fear in those who host it that translates into constant oxidative stress to the limit of breaking the production of
dopamine
established by a process of assigning transgenerational information (mechanics unknown to science) whose trauma is originally It spreads among members of future generations, causing intense fear in those who host it that translates into constant oxidative stress to the limit of breaking the production of
dopamine
ManuCalma
in
Cure Parkinson's
7 months ago
the curse of lifelong RLS…
Three years ago, at the age of 60, I got to see the professor himself and he advised
Dopamine
Agonists , either Ropinirole or the Rotigotine Patch, despite my ferritin being way below 100 my request for an iron transfusion was refused.
Three years ago, at the age of 60, I got to see the professor himself and he advised
Dopamine
Agonists , either Ropinirole or the Rotigotine Patch, despite my ferritin being way below 100 my request for an iron transfusion was refused.
soundofmetal
in
Restless Legs Syndrome
9 months ago
Kratom anti-depressant, anti-psychotic, anti-anxiety herb!
Serotonin,
Dopamine
, GABA, and Noradreniline. It corrected the imbalance. I remember having a conversation and I wasn't compelled to act on the negative images in my head. I was no longer abscessed. I could focus and reply normaly. Kratom for me with my disorders cured my mental Illnesses.
Serotonin,
Dopamine
, GABA, and Noradreniline. It corrected the imbalance. I remember having a conversation and I wasn't compelled to act on the negative images in my head. I was no longer abscessed. I could focus and reply normaly. Kratom for me with my disorders cured my mental Illnesses.
PureOCDdude
in
My OCD Community
8 months ago
Sigh... 😔🥱😒 Hallucinations side effects from meds on top of neck & back pain affecting sleep schedule
I think it was a mistake to start him on the meds - I don't think he needs more
dopamine
.
I think it was a mistake to start him on the meds - I don't think he needs more
dopamine
.
daughter-Advocate
in
Cure Parkinson's
9 months ago
Weaning off high dose Pramipexole
Seemed odd as it is a
dopamine
drug but it worked to knock back the symptoms to the evening. . Then over time I started adapting and required higher and higher doses. I've now taken 1.5mg a day for the past 4 or 5 years, which is way high and augmenting again.
Seemed odd as it is a
dopamine
drug but it worked to knock back the symptoms to the evening. . Then over time I started adapting and required higher and higher doses. I've now taken 1.5mg a day for the past 4 or 5 years, which is way high and augmenting again.
lessergoldfinch
in
Restless Legs Syndrome
10 months ago
Resting Tremor Stopped Briefly With Hypnosis
Perhaps the threshold damage to
dopamine
neurons had been reached. But the hypnotic suggestion still works to briefly stop both the tremor and muscle contraction. So, is chronic muscle contraction prodromal to PD?
Perhaps the threshold damage to
dopamine
neurons had been reached. But the hypnotic suggestion still works to briefly stop both the tremor and muscle contraction. So, is chronic muscle contraction prodromal to PD?
Likii
in
Cure Parkinson's
9 months ago
Rytary… might stop??
Rytary gives me 4 hour ON on a 5 hour dose cycle, BUT, the afternoon slump around 3 pm (halfway between doses, but when endogenous
dopamine
is naturally low) is WORSE with some unexpected foot dystonia.
Rytary gives me 4 hour ON on a 5 hour dose cycle, BUT, the afternoon slump around 3 pm (halfway between doses, but when endogenous
dopamine
is naturally low) is WORSE with some unexpected foot dystonia.
rebtar
in
Cure Parkinson's
11 months ago
Phase III trial for Cerevance’s lead CNS therapy, CVN424, in patients with Parkinson’s disease.
CVN424 is a non-
dopamine
therapy that inhibits G protein-coupled receptor 6 (GPR6), which is an orphan receptor as it has no naturally produced agonist that activates the receptor. The GPR6 inhibition can potentially improve motor and non-motor manifestations of Parkinson’s.
CVN424 is a non-
dopamine
therapy that inhibits G protein-coupled receptor 6 (GPR6), which is an orphan receptor as it has no naturally produced agonist that activates the receptor. The GPR6 inhibition can potentially improve motor and non-motor manifestations of Parkinson’s.
Farooqji
in
Cure Parkinson's
12 days ago
if there is a vaccine for PD or PD can be prevented
there will be no motivation to find a cure (to grow back
dopamine
neurons), after we this batch all die, there will be no more PD in the world, is that possible?
there will be no motivation to find a cure (to grow back
dopamine
neurons), after we this batch all die, there will be no more PD in the world, is that possible?
limcheeese22
in
Cure Parkinson's
1 year ago
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