Nasal administraton of dopamine

[Boscoejean]

This research is being done in Australia

"Direct nose-to-brain delivery of dopamine is company’s goal

Gel given directly to nasal passages might be more effective, longer lasting"

By Andrea Lobo

parkinsonsnewstoday.com/new...

[park_bear]

If this works it should make for a much steadier level of dopamine.

[Parkie1]

The answer to the slow gut problem?

[Farooqji]

is it different from INBRIJA (levodopa inhalation powder)

inbrija.com/

[MIKEYDAY in reply to Farooqji]

INBRIJA is an inhaler going direct to lungs.

[Boscoejean in reply to MIKEYDAY]

so does the person inhale this through the mouth?

[EmsXen33 in reply to Boscoejean]

I use Inbrija - it's inhaled through the mouth like you're smoking a cigar. It's designed to provide a quick boost, not be the primary form of C/L delivery. I use it sometimes to get back on track when a meal has interfered with my oral med absorption. It works well for me, but I try not to use it that often because I don't know what the long-term effects are to lungs and throat.

[Gallowglass]

Prayers for this

[barrie1757]

There were some studies doing this with glutathione for Parkinson’s too. Sounds like a good delivery method.

[Boscoejean in reply to barrie1757]

I would like to see the follow up on that so time for a search

[Boscoejean in reply to barrie1757]

Conclusions: Although predicted improvements in PD total and motor scores were observed, these data do not suggest (in)GSH is superior to placebo after a three month intervention. The symptomatic effects are sufficient to warrant a delayed-start or wash-out design study for disease-modification trials. Whether long-term use of (in)GSH leads to clinical improvements that are sustained and significantly different than placebo will require appropriately-powered longer-duration studies in larger cohorts. The improvement in the placebo arm was more robust than has been observed in previous PD studies and warrants further investigation.

pubmed.ncbi.nlm.nih.gov/284...

[bassofspades]

The article says Dopamine and/or Levodopa. It would have to be Levodopa because Dopamine cannot cross the blood brain barrier. Levodopa can, though.

[Boscoejean]

the challenges of intranasal administration:

"drugs can be delivered intranasally, including some that target the brain. However, there are several challenges to overcome, including mucus secretion and the mucociliary clearance mechanism.

How can drugs be delivered intranasally?

Nanoparticles

Drug-loaded nanoparticles can penetrate nasal mucus and be transported to the brain.

Mucoadhesive nanoparticles

These nanoparticles attach to nasal mucus, but can be partially lost during mucociliary clearance.

Antiadhesive nanoparticles

These nanoparticles weakly interact with mucus, which increases their diffusion rate across the mucus layer.

In-situ gels

These gels increase the viscosity of the formulation, which can increase the retention time of the drug.

Atomizers

These devices spray the medication across a large surface area of the nasal mucosa.

Challenges to intranasal delivery

Mucus secretion: Mucus secretion is a primary challenge to drug absorption.

Mucociliary clearance: This mechanism can limit the amount of drug that is absorbed.

Particle size: Larger droplets are more likely to cause irritation and reflexive sneezing.

Drug properties: The size, molecular weight, and lipophilic-hydrophilic balance of the drug can limit its ability to be delivered intranasally.

Advantages of intranasal delivery Can avoid the hepatic first-pass effect, Can bypass the blood–brain barrier, and Can be easy to use. "