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Docetaxel
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Stampede Trial: Arm H
Arm H found significant improvement by adding SBRT/SABR to Primary Prostate gland in addition to Lupron, Abi,
Docetaxel
(Triple ADT) to Oligometastatic Men, or low Metastatic Burden Men. 81% of Men were Alive at 3yrs of all causes vs 73% with Trip ADT alone.
Arm H found significant improvement by adding SBRT/SABR to Primary Prostate gland in addition to Lupron, Abi,
Docetaxel
(Triple ADT) to Oligometastatic Men, or low Metastatic Burden Men. 81% of Men were Alive at 3yrs of all causes vs 73% with Trip ADT alone.
Spyder54
in
Advanced Prostate Cancer
2 years ago
Wondering which arm of STAMPEDE dictated my 18 to 16 month ADT plus Zytiga treatment plan ?
The STAMPEDE article posted by today by Spyder includes
Docetaxel
( which I’m not taking ) in the trial . Does anyone know which arm of Stampede dictates my treatment plan ?
The STAMPEDE article posted by today by Spyder includes
Docetaxel
( which I’m not taking ) in the trial . Does anyone know which arm of Stampede dictates my treatment plan ?
PBnative
in
Advanced Prostate Cancer
2 years ago
No longer undetectable
We treated aggressively with Lupron,
Docetaxel
followed by Zytiga, and then 42 sessions of whole pelvic radiation. PSA went to undetectable (<0.01) within 6 months, and with my MO’s blessing, we stopped all meds in summer of 2019. T never recovered above 100.
We treated aggressively with Lupron,
Docetaxel
followed by Zytiga, and then 42 sessions of whole pelvic radiation. PSA went to undetectable (<0.01) within 6 months, and with my MO’s blessing, we stopped all meds in summer of 2019. T never recovered above 100.
Canoehead
in
Advanced Prostate Cancer
2 years ago
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Looking for thoughts on next treatment after Docetaxel
. - Started on
Docetaxel
in Fall 2021 for 10 cycles. - PSA dropped to 10 but the mets had a very slight increase. So what's next: more chemo, Radium 223 (I have no pain), PARP inhibitor, or something else. Thanks for your thoughts.
. - Started on
Docetaxel
in Fall 2021 for 10 cycles. - PSA dropped to 10 but the mets had a very slight increase. So what's next: more chemo, Radium 223 (I have no pain), PARP inhibitor, or something else. Thanks for your thoughts.
davebliz
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
And this also appears to be the case for adding adjuvant ADT to
docetaxel
chemotherapy. Consider discussing the following article with your RO or MO. ncbi.nlm.nih.gov/pmc/articl...
And this also appears to be the case for adding adjuvant ADT to
docetaxel
chemotherapy. Consider discussing the following article with your RO or MO. ncbi.nlm.nih.gov/pmc/articl...
MateoBeach
in
Advanced Prostate Cancer
2 years ago
Testosterone “Flare” (Or Testosterone?) Timing to Optimize Salvage Radiation Therapy
And this also appears to be the case for adding adjuvant ADT to
docetaxel
chemotherapy. Consider discussing the following article with your RO or MO. ncbi.nlm.nih.gov/pmc/articl...
And this also appears to be the case for adding adjuvant ADT to
docetaxel
chemotherapy. Consider discussing the following article with your RO or MO. ncbi.nlm.nih.gov/pmc/articl...
MateoBeach
in
Fight Prostate Cancer
2 years ago
DOCETAXEL FATIGUE
I have had 2 rounds of somewhat reduced dose
docetaxel
. PSA down after the first round which is terrific, but I am trying to wrap my head around the fatigue I am experiencing.
I have had 2 rounds of somewhat reduced dose
docetaxel
. PSA down after the first round which is terrific, but I am trying to wrap my head around the fatigue I am experiencing.
Arthur479
in
Advanced Prostate Cancer
2 years ago
PSA is increasing with Docetaxel, what should we do now ?
My father is now 66 years old, back in Dec 2020 he was diagnosed with Advanced PC now his PSA rised to 6.630 ng/mL on
Docetaxel
, what are our options given that my father is not in USA (in Egypt) ? or how should we proceed if someone has a positive experience after
Docetaxel
stop working ?
My father is now 66 years old, back in Dec 2020 he was diagnosed with Advanced PC now his PSA rised to 6.630 ng/mL on
Docetaxel
, what are our options given that my father is not in USA (in Egypt) ? or how should we proceed if someone has a positive experience after
Docetaxel
stop working ?
mgaa
in
Advanced Prostate Cancer
2 years ago
My life has gotten much more complicated since Abiraterone suddenly quit working about 6 months ago
There may be some
Docetaxel
in the near future to take care of the rising PSA. Eligard appears to be keeping the testosterone level completely under control.
There may be some
Docetaxel
in the near future to take care of the rising PSA. Eligard appears to be keeping the testosterone level completely under control.
diamondrn
in
Advanced Prostate Cancer
2 years ago
Triplet Systemic Therapy for low volume mCSPC
The very recent ARASENS trial results helped me finalize treatment plan for low volume mCSPC —> ADT + Daralutamide + SBRT +
Docetaxel
. This aggressive plan would not have been the case months ago without the scans or trial results.
The very recent ARASENS trial results helped me finalize treatment plan for low volume mCSPC —> ADT + Daralutamide + SBRT +
Docetaxel
. This aggressive plan would not have been the case months ago without the scans or trial results.
PGDuan
in
Advanced Prostate Cancer
2 years ago
VERU-111 sounds promising, and may be a Godsend for those with very low blood counts who can't get other treatments
“As a benchmark, other drugs that have been used in these patients, like
docetaxel
chemotherapy or additional androgen targeting agents, typically achieve a median progression free survival between 3 and 4 months.
“As a benchmark, other drugs that have been used in these patients, like
docetaxel
chemotherapy or additional androgen targeting agents, typically achieve a median progression free survival between 3 and 4 months.
JLS1
in
Advanced Prostate Cancer
2 years ago
The Journey continues
Ten months ago after trying
Docetaxel
, Xtandi and just 2 cycles of Jevtana all since 2019, our oncologist said the only thing left to do was a clinical trial. We were referred to another cancer center that was a NCI center as the clinic we were at was not. A clinical trial was begun last August.
Ten months ago after trying
Docetaxel
, Xtandi and just 2 cycles of Jevtana all since 2019, our oncologist said the only thing left to do was a clinical trial. We were referred to another cancer center that was a NCI center as the clinic we were at was not. A clinical trial was begun last August.
Presby
in
Advanced Prostate Cancer
2 years ago
ARASENS: Darolutamide + ADT + Docetaxel may become new SOC for mHSPC - from ASCO GU Symposium 2022
CC, reported significant overall survival from 3 ARASENS trial results when compared to placebo + ADT +
Docetaxel
. A 32% reduction in the risk of death with no increased toxicity (pub. in NEJofM and wrap-up edition of ASCO GU 2022 Symposium).
CC, reported significant overall survival from 3 ARASENS trial results when compared to placebo + ADT +
Docetaxel
. A 32% reduction in the risk of death with no increased toxicity (pub. in NEJofM and wrap-up edition of ASCO GU 2022 Symposium).
JRPnSD
in
Advanced Prostate Cancer
2 years ago
Why finish Taxotere /Docetaxel treatment?
Brief history- 8/2011 psa 47, G9, open RP. 0 club until 7/2014. Fast forward to 5/2022- no further treatments, psa 57, 5 involved inquinal lymph nodes swollen, mass extending to hip with bone metastases. Leg lymphedema, painful groin and hip causing severe limp. 5/2022 start Orgovyx/Regulolix HT and
Brief history- 8/2011 psa 47, G9, open RP. 0 club until 7/2014. Fast forward to 5/2022- no further treatments, psa 57, 5 involved inquinal lymph nodes swollen, mass extending to hip with bone metastases. Leg lymphedema, painful groin and hip causing severe limp. 5/2022 start Orgovyx/Regulolix HT and
Startech
in
Advanced Prostate Cancer
2 years ago
PEACE1 data now published
Interestingly,
docetaxel
did not add to the incidence of severe or fatal adverse events.
Interestingly,
docetaxel
did not add to the incidence of severe or fatal adverse events.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Next steps? Zytiga and Radiation
He also said
docetaxel
is on the table as well. He started with this treatment in July 2021 and it was really effective as lung and liver mets greatly decreased but he had pretty bad side effects. Based on what I've read, it seems to be the right steps. I'd love to hear your thoughts.
He also said
docetaxel
is on the table as well. He started with this treatment in July 2021 and it was really effective as lung and liver mets greatly decreased but he had pretty bad side effects. Based on what I've read, it seems to be the right steps. I'd love to hear your thoughts.
dch1953
in
Advanced Prostate Cancer
2 years ago
30 months with PCA - experiences with ADT, Docetaxel, Xtandi / Nubeqa, Provenge and experimental immunotherapy trial.
SoC was ADT and chemo (
Docetaxel
). His PSA started to drop after starting ADT and completing a round of chemo along with Cemiplimab. By August 2020 his PSA had dropped and stabilized at 2.
SoC was ADT and chemo (
Docetaxel
). His PSA started to drop after starting ADT and completing a round of chemo along with Cemiplimab. By August 2020 his PSA had dropped and stabilized at 2.
Namork
in
Advanced Prostate Cancer
2 years ago
Triplet Systemic Therapy for low volume mCSPC
The plans is —> ADT + Darolutamide + SBRT +
Docetaxel
. This aggressive plan would not have been the recommendation just a months ago without the latest scans or recent trial results (and continued fast PSA doubling time).
The plans is —> ADT + Darolutamide + SBRT +
Docetaxel
. This aggressive plan would not have been the recommendation just a months ago without the latest scans or recent trial results (and continued fast PSA doubling time).
PGDuan
in
Advanced Prostate Cancer
2 years ago
Life expectancy shock revelation
This would be after finishing
Docetaxel
then having 2nd line Cabazitaxel which would work for 14 - 16 months. I am completely shocked and I'm obviously looking to retire now. With me being so far down the treatment path it's so less likely his prediction will be wrong isn't it?
This would be after finishing
Docetaxel
then having 2nd line Cabazitaxel which would work for 14 - 16 months. I am completely shocked and I'm obviously looking to retire now. With me being so far down the treatment path it's so less likely his prediction will be wrong isn't it?
konichiwa12
in
Advanced Prostate Cancer
2 years ago
HDR Brachytherapy after the 20 fractions?
Hi all I have recently finished 3 x Lu-177 and 3 x
Docetaxel
infusions whilst hormone sensitive. I have been on Degarelix since November so no idea what's doing what but but my PSA has fallen from 17.6 to 0.19.
Hi all I have recently finished 3 x Lu-177 and 3 x
Docetaxel
infusions whilst hormone sensitive. I have been on Degarelix since November so no idea what's doing what but but my PSA has fallen from 17.6 to 0.19.
Brysonal
in
Advanced Prostate Cancer
2 years ago
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