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Docetaxel
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Should Early Use of Chemotherapy Be Avoided in the Treatment of Metastatic Prostate Cancer?
"According to the evidences so far, including this study,
docetaxel
should be recommended as second-line treatment for metastatic CRPC patients who received first-line ARPI. However,
docetaxel
is selected as second-line treatment only for limited patients in real-world clinical practice.
"According to the evidences so far, including this study,
docetaxel
should be recommended as second-line treatment for metastatic CRPC patients who received first-line ARPI. However,
docetaxel
is selected as second-line treatment only for limited patients in real-world clinical practice.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
ADT + Abi + Docetaxel for metastatic prostate cancer?
Would be grateful to hear people's thoughts on the triple-therapy (ADT+Abi+
Docetaxel
) in his situation. Thoughts? (https://ascopost.com/news/september-2021/peace-1-and-stampede-trials-abiraterone-acetate-plus-prednisolone-in-prostate-cancer/)
Would be grateful to hear people's thoughts on the triple-therapy (ADT+Abi+
Docetaxel
) in his situation. Thoughts? (https://ascopost.com/news/september-2021/peace-1-and-stampede-trials-abiraterone-acetate-plus-prednisolone-in-prostate-cancer/)
Shanti1
in
Advanced Prostate Cancer
2 years ago
My Jevtana/Carboplatin results to date. Part Two.
It’s because of you that I was started on this combo after 7 previous chemo infusions (3
Docetaxel
, 4 Jevtana) with poor results.
It’s because of you that I was started on this combo after 7 previous chemo infusions (3
Docetaxel
, 4 Jevtana) with poor results.
Mount_Rainier
in
Advanced Prostate Cancer
2 years ago
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How to cope and combat Docetaxel side effects without compromising its effectiveness
Is there are role for Naturopathic therapies to help with se of
docetaxel
? Does anyone have experience with these practitioners, good or bad? Any suggestions on what I can do to help with my recovery from
docetaxel
will be helpful and taken seriously. Thank you
Is there are role for Naturopathic therapies to help with se of
docetaxel
? Does anyone have experience with these practitioners, good or bad? Any suggestions on what I can do to help with my recovery from
docetaxel
will be helpful and taken seriously. Thank you
Grateful4this
in
Advanced Prostate Cancer
2 years ago
Daralutamide and Survival in Metastatic, Hormone Sensitive Prostate Cancer
CONCLUSIONS In this trial involving patients with metastatic, hormone-sensitive prostate cancer, overall survival was significantly longer with the combination of darolutamide, androgen-deprivation therapy, and
docetaxel
than with placebo plus androgen-deprivation therapy and
docetaxel
, and the addition
CONCLUSIONS In this trial involving patients with metastatic, hormone-sensitive prostate cancer, overall survival was significantly longer with the combination of darolutamide, androgen-deprivation therapy, and
docetaxel
than with placebo plus androgen-deprivation therapy and
docetaxel
, and the addition
Graham49
in
Advanced Prostate Cancer
2 years ago
At what point - stereotactic treatment versus chemo
He is uncertain where to go straight to
docetaxel
or zapping the 4 most active spots (and maybe more). He will be getting a consult to help him decide. My question - what is the typical cut off for making this choice?
He is uncertain where to go straight to
docetaxel
or zapping the 4 most active spots (and maybe more). He will be getting a consult to help him decide. My question - what is the typical cut off for making this choice?
Arthur479
in
Advanced Prostate Cancer
2 years ago
Chemo
My husband has had 6 rounds of
Docetaxel
, 3 rounds of jentava and now two rounds of Jentava along with Carboplatin. None have even touched the psa and some progression on the scans. This is taking a huge toll. He has been on Zytiga, Lynparza, Keytruda now the chemo. Just asking opinions.
My husband has had 6 rounds of
Docetaxel
, 3 rounds of jentava and now two rounds of Jentava along with Carboplatin. None have even touched the psa and some progression on the scans. This is taking a huge toll. He has been on Zytiga, Lynparza, Keytruda now the chemo. Just asking opinions.
Fight11
in
Advanced Prostate Cancer
2 years ago
PSA rising a concern? Mets to bones, livers, lungs and lymph nodes
He started Firmagon and then on Zoladex and then 6 cycles of
docetaxel
which finished at the end of November. His mets in general have reduced significantly in both the liver and lungs. His PSA was <0.02 in November, taken on the same day as his last cycle of
docetaxel
.
He started Firmagon and then on Zoladex and then 6 cycles of
docetaxel
which finished at the end of November. His mets in general have reduced significantly in both the liver and lungs. His PSA was <0.02 in November, taken on the same day as his last cycle of
docetaxel
.
dch1953
in
Advanced Prostate Cancer
2 years ago
Next Move
Guidelines point to
docetaxel
or Jevtana, but still stuck on those neuropathy side effects. I feel that if I see increased neuropathy from the chemo it will be the end of my mobility, as I have gone from cane to rollator since the cancer was diagnosed.
Guidelines point to
docetaxel
or Jevtana, but still stuck on those neuropathy side effects. I feel that if I see increased neuropathy from the chemo it will be the end of my mobility, as I have gone from cane to rollator since the cancer was diagnosed.
Kentucky1
in
Advanced Prostate Cancer
2 years ago
ARASENS Trial
CONCLUSIONS In this trial involving patients with metastatic, hormone-sensitive prostate cancer, overall survival was significantly longer with the combination of darolutamide, androgen-deprivation therapy, and
docetaxel
than with placebo plus androgen-deprivation therapy and
docetaxel
, and the addition
CONCLUSIONS In this trial involving patients with metastatic, hormone-sensitive prostate cancer, overall survival was significantly longer with the combination of darolutamide, androgen-deprivation therapy, and
docetaxel
than with placebo plus androgen-deprivation therapy and
docetaxel
, and the addition
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Has anyone with ischemic heart had chemo with docetaxel?
My MO wants to start me on
Docetaxel
in a week. Has anyone with ischemic heart had the same treatment? What are the risks?
My MO wants to start me on
Docetaxel
in a week. Has anyone with ischemic heart had the same treatment? What are the risks?
Oldie68
in
Advanced Prostate Cancer
2 years ago
Not the best news I've had
Upshot is that the alternative now is chemotherapy with
Docetaxel
and Nintedamib. The side effects look very severe to me!! I'm swinging between just not having any further treatment and taking things as they come and enjoying life and having the treatment.
Upshot is that the alternative now is chemotherapy with
Docetaxel
and Nintedamib. The side effects look very severe to me!! I'm swinging between just not having any further treatment and taking things as they come and enjoying life and having the treatment.
magstherunner
in
The Roy Castle Lung Cancer Foundation
2 years ago
Another victory for "triplet"therapy for newly diagnosed metastatic men.
All 1,306 patients treated from 2016-2018 were randomized to receive darolutamide (DARO) or placebo (PBO) on top of
docetaxel
and ADT.
All 1,306 patients treated from 2016-2018 were randomized to receive darolutamide (DARO) or placebo (PBO) on top of
docetaxel
and ADT.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Chasing rivals, Bayer files Nubeqa for new prostate cancer
The latest filings for Nubeqa in the US and Europe are based on the ARASENS trial which showed that adding the drug to androgen deprivation therapy (ADT) and
docetaxel
chemo led to a statistically significant improvement in overall survival (OS) compared to ADT plus
docetaxel
and placebo.
The latest filings for Nubeqa in the US and Europe are based on the ARASENS trial which showed that adding the drug to androgen deprivation therapy (ADT) and
docetaxel
chemo led to a statistically significant improvement in overall survival (OS) compared to ADT plus
docetaxel
and placebo.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Docetaxel and Nintedanib. Any experience with these?
Hi. Has anyone had this treatment and can you let me know how you got on. Side effects etc?
Hi. Has anyone had this treatment and can you let me know how you got on. Side effects etc?
magstherunner
in
The Roy Castle Lung Cancer Foundation
2 years ago
Update, diagnosed 12/26/2018
Starter
docetaxel
in March thru July. After chemo PSA was .085. Had a tough time with chemo. Low blood counts all around. MO didn't start me on other meds at the time, only lupron. PSA rose slowly till 0.12 March 2020 up to 0,64 in June.
Starter
docetaxel
in March thru July. After chemo PSA was .085. Had a tough time with chemo. Low blood counts all around. MO didn't start me on other meds at the time, only lupron. PSA rose slowly till 0.12 March 2020 up to 0,64 in June.
Altamonttt
in
Advanced Prostate Cancer
2 years ago
PSA Still Climbing - Scans Almost Stable
From all of your experience, when the PSA begins to rise after
docetaxel
, what have you guys found that has worked for you in addition to the Lupron/Eligard? I have tried Zytiga prior to
docetaxel
and it did not work at all.
From all of your experience, when the PSA begins to rise after
docetaxel
, what have you guys found that has worked for you in addition to the Lupron/Eligard? I have tried Zytiga prior to
docetaxel
and it did not work at all.
Hidden
in
Advanced Prostate Cancer
2 years ago
My experience and my thoughts about undergoing radioligand therapy using the PSMA-617 ligand loaded with 177Lu and 225Ac isotopes. Part 1.
Having passed all standard methods of treatment: 6 courses of
Docetaxel
, hormonal therapy with anti–androgens of the first and second generation against the background of ADT, I managed to reduce my PSA to a value of 24 ng / ml with unchanged T = 0.087 nmol / L., which very soon began to grow rapidly
Having passed all standard methods of treatment: 6 courses of
Docetaxel
, hormonal therapy with anti–androgens of the first and second generation against the background of ADT, I managed to reduce my PSA to a value of 24 ng / ml with unchanged T = 0.087 nmol / L., which very soon began to grow rapidly
RusLand
in
Advanced Prostate Cancer
2 years ago
Update w/ Questions: Tumor growth w/o PSA rise; Chemo Round 2, Cabazitaxel This Time
Quick recap: diagnosed in 2010 at age 44, got robotic RP, then eventually radiation, then chemo (taxotere/
docetaxel
) and adt (Lupron) in 2016. My psa stayed slow growing for awhile, kept down by 10 months of casodex before growing.
Quick recap: diagnosed in 2010 at age 44, got robotic RP, then eventually radiation, then chemo (taxotere/
docetaxel
) and adt (Lupron) in 2016. My psa stayed slow growing for awhile, kept down by 10 months of casodex before growing.
BillNIttles
in
Advanced Prostate Cancer
2 years ago
Lupron and infusion (Taxotere/Docetaxel) on the same day?
Has anybody had a Lupron injection + taxotere/
docetaxel
infusion on the same day? Were the side effects worse or the same as receiving them separately, more than a week apart? I am scheduled for a double whammy in two weeks. Considering asking to postpone the Lupron by a week.
Has anybody had a Lupron injection + taxotere/
docetaxel
infusion on the same day? Were the side effects worse or the same as receiving them separately, more than a week apart? I am scheduled for a double whammy in two weeks. Considering asking to postpone the Lupron by a week.
Oldie68
in
Advanced Prostate Cancer
2 years ago
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