Stampede Trial: Arm H

[Spyder54]

So the Stampede Trial is one of the largest Trials with 10,000 Men, mostly from the UK, Switzerland, and Canada. It started over 10 years ago. It has many Arms which try different combinations. Arm A,B,C,etc.. Arm H found significant improvement by adding SBRT/SABR to Primary Prostate gland in addition to Lupron, Abi, Docetaxel (Triple ADT) to Oligometastatic Men, or low Metastatic Burden Men. 81% of Men were Alive at 3yrs of all causes vs 73% with Trip ADT alone. Those are some of the best 3 yr numbers of all Arms in Trial. Not new news, but most SOC still does not offer.

stampedetrial.org/media-sec...

[EdBar]

While my metastatic burden was pretty high and not low, early on after my dx I had my prostate and several nodes radiated by a brilliant radonc who suggested it. My urologist was against it. I later had chemo per CHAARTED and I have been on triple ADT since almost day one - “the Snuffy Myers protocol “. 8 years later I’m still here, Snuffy once told me that “having my prostate radiated was one of the best things I did early on, kill the mothership “. Perhaps he was correct.

Ed

[PBnative in reply to EdBar]

Greetings Ed ,Thanks for posting the link to the Stampede . I have “ low metastatic load “ based on a clean PSMA -PET scan but I am high risk based on PSA 61 ( I was Gleason 6 on only biopsy in 2009 .)

Taking Avodart for ten years and doing many lifestyle changes per Snuffy Meyers kept my PSA low for a decade but when I stopped Avodart for a month 3 years ago PSA began to rise . I finally got 26 radiation treatments at MSK in January and started Orgovyx and Zytiga with prednisone in November 2021 . MSK RO and MO Rx ‘d 18 to 36 months of ADT plus Zytiga based on STAMPEDE . This report includes Docetaxel ( which I’m not taking ) in the trial . Do you know which arm applies to me ?

[EdBar in reply to PBnative]

No I’m not sure, Spyder 54 posted the link BTW.

Ed

[PBnative in reply to EdBar]

Thanks , I saw that before I posted my query as a post

[arete1105]

Lupron will lower your T count. Those side effects will include low energy, no stamina, no sexual interest (my T got to under 20), no sexual performance ( for me it didn't matter at my age), easily fatigued. I got to the point where QOL was more important than longevity.