Experiences with

Docetaxel

[Epub ahead of print] Hyperglycaemia-induced resistance to Docetaxel is negated by metformin: a role for IGFBP-2. Biernacka K1, Persad RA2, Bahl A3, Gillatt D4, Holly JM5, Perks CM6.

How many of you had either short- or long-term peripheral neuropathy during or after docetaxel chemotherapy? If you did, how severe was it, and did it limit activities such as driving, writing, playing tennis (or other sports)? Also, how did you treat it and how well did the treatments work?

Cabazitaxel belongs to the same family (taxanes) as Docetaxel (Taxotere). Fisetin might act synergistically. ... Eventually, two products came to market. Oddly, with very similar names.

Cabazitaxel belongs to the same family (taxanes) as Docetaxel (Taxotere). Fisetin might act synergistically. ... Eventually, two products came to market. Oddly, with very similar names.

I am now starting on hormone therapy and chemotherapy with Docetaxel for 6 cycles. Does anybody have any idea of what I'm in for?

He reluctantly decided on Jevtana and external beam radiation even though he had a difficult time with docetaxel. Anyone have more side effects with cabazitaxel than with docetaxel? We are not that thrilled with Jevtana as his PSA only climbed and bone mets got worse while on docetaxel.

I am just about to start on Docetaxel and Nintedanib and have been told that this will give me weeks or months more life. I understand that the side effects are quite severe and wondered if anyone else has been on these drugs and could tell me their experience. Thanks, Lorna

"The Mainsail trial was a multinational randomized phase 3 study of 1059 patients with mCRPC receiving docetaxel, prednisone, and lenalidomide (DPL) or docetaxel, prednisone, and a placebo (DP). Study patients were treated until progressive disease or unacceptable adverse effects occurred.

"The synergistic administration of piperine and docetaxel significantly improved the anti-tumor efficacy of docetaxel in a xenograft model of human CRPC."

Zoladex for five and a half years, TRAPEZE trial - docetaxel and zoladronic acid. Abiraterone (had to come off for toxicity reasons), Enzalutamide and now cabazitaxel.

Parthenolide also augmented the in vivo efficacy of docetaxel and restored sensitivity to anti-androgen therapy." [7c] (2009 - U.S.)

Hi, Since my last post about Immunotherapy a lot has happened, I was initially going to start on Docetaxel/Nintedanib tomorrow as the trial at the Christie was full. Then i had a call from them to say there was a place for me after all and i start the screening process on Thursday.

The effects and mechanisms of nitroglycerin on the enhancement of chemosensitivity to docetaxel and carboplatin regimen (DCb) in patients with lung adenocarcinoma have not been reported."

Not clear what these two Docetaxel trials hope to achieve. [4a] "Docetaxel Plus Lycopene in Castration Resistant, Chemotherapy-Naïve Prostate Cancer Patients" Lyc-O-Mato Recruiting.

I know my Seattle doc is participating in a trial using docetaxel, Carboplatin and sirolimus. The doctor ar Duke mentioned trying oxaliplatin with Gezmar.

the spelling) which he sailed through no side effects, had follow up scans where it showed it had shrunk a bit, so friday we went to the oncologist and were told it had grown although they couldnt guarantee that it was cancer and not a chest infection, so Tuesday he starts Chemo again this time on Docetaxel

I was offered Docetaxel/ nintednib but asked if i could have either imunotherapy or some other targeted therapy instead. I was sent to the Christie in the hope of joining a trial but was told on arrival that the trial was full.

"Conclusions: ADI-PEG 20 demonstrated reasonable toxicity in combination with docetaxel. Promising clinical activity was noted, and expansion cohorts are now accruing for ... castrate-resistant prostate cancer ... at a recommended phase II dose of 36 mg/m2." ...

"We included consecutive metastatic CRPC patients treated with enzalutamide after docetaxel" "Data collected on 193 patients from 9 centers were evaluated." "The median baseline NLR was 3.2."

I had BCS surgery followed by a sandwich therapy of 4 cycles of chemotherapy FEC, radiation and 4 cycles of docetaxel. My BC is stage 2A, Pt2n0m0, ER/PR positive and Her2 neu negative by FISH test. My treatment completed on February 2016 and currently I am on hormone therapy taking tamoxifen daily.